Cobas c8000 analyzer

Manufactured by Roche

Sourced in Switzerland

The Cobas C8000 analyzer is a clinical chemistry system designed for high-throughput automated analysis of various clinical parameters. It is capable of performing a wide range of assays, including but not limited to, enzymatic, immunological, and electrochemical analyses. The Cobas C8000 is engineered to deliver efficient and reliable results to support clinical decision-making.

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Lab products found in correlation

Microtainer sst tube, by BD (1 mentions) Multigent iron kit, by Abbott (1 mentions) Architect c16000 automated analyzer, by Abbott (1 mentions) Lactate pro, by Arkray (1 mentions)

2 protocols using cobas c8000 analyzer

Serum Hepcidin and Iron Quantification

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Blood was taken by cardiac puncture immediately after euthanising mice. Serum was prepared by centrifugation of clotted blood at 8000 x g for 5minutes in BD Microtainer SST tubes (Beckton Dickinson). Serum hepcidin was quantified by competitive ELISA using the Hepcidin-Murine Compete Kit (Intrinsic Lifesciences) according to the manufacturer’s protocol. For mice given FeSO₄ gavage, serum iron was quantified using the MULTIGENT Iron Kit on the Abbott Architect c16000 automated analyzer (Abbott Laboratories) at John Radcliffe Hospital, UK. For Hfe^−/− and Hamp1^−/− mice given CDDO-Im, serum irons were quantified in a Cobas C8000 analyzer (Roche Diagnostics, Mannheim, Germany) at Centro Hospitalar do Porto.

Lim P.J., Duarte T.L., Arezes J., Garcia-Santos D., Hamdi A., Pasricha S.R., Armitage A.E., Mehta H., Wideman S., Santos A.G., Santos-Gonçalves A., Morovat A., Hughes J.R., Soilleux E., Wang C.Y., Bayer A.L., Klenerman P., Willberg C.B., Hartley R.C., Murphy M.P., Babitt J.L., Ponka P., Porto G, & Drakesmith H. (2019). Nrf2 controls iron homeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin. Nature metabolism, 1(5), 519-531.

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Acute Hormone and Muscle Damage Response

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Blood samples were collected from the antecubital vein after 10 minutes of lying supine to determine the acute responses of testosterone, cortisol, and creatine kinase, and each sample was taken by trained practitioners via venipuncture. After collection, the samples were centrifuged at 3000 rpm for 10 minutes at room temperature. Plasma was analyzed for testosterone, cortisol, and creatine kinase activity using commercially available kits (Roche Diagnostic Limited, Charles Avenue, Burgess hill) on a Cobas C8000 analyzer (Roche Diagnostics, Switzerland).
Lactate was analyzed from blood taken from a capillary using a lactate analyzer (Lactate pro, Arkray).

Johnston M.J., Cook C.J., Drake D., Costley L., Johnston J.P, & Kilduff L.P. (2016). The Neuromuscular, Biochemical, and Endocrine Responses to a Single-Session Vs. Double-Session Training Day in Elite Athletes. Journal of strength and conditioning research, 30(11).

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