Total IGF-1R, IRS-1, p85, ERK1/2 and Akt and phosphorylated (Tyr1135/1136) IGF-1R, (Tyr458) p85, (Thr202/Tyr204) ERK1/2, (Ser473) Akt, and GAPDH antibody (rabbit) primary antibodies were obtained from Cell Signaling (Danvers, MA). Secondary goat anti-rabbit IgG antibodies (IRDye 800CW) were purchased from LI-COR Biotechnology (Lincoln, NE). AG 1024, a specific IGF-1R phosphorylation inhibitor, was purchased from Selleck Chemicals (Houston, TX). IGF-1R siRNA was obtained from Cell Signaling (Danvers, MA). D-mannitol and glucose were purchased from Sigma (St. Louis, MO). KZ-41 (Fig 1 ) was synthesized in Dr. Duane Miller’s laboratory and verified to be >96% pure by nuclear magnetic resonance spectroscopy [17 (link)].
Thr202 tyr204 erk1 2
Manufactured by Cell Signaling Technology
Sourced in United States
The (Thr202/Tyr204) ERK1/2 is a laboratory antibody product that targets the phosphorylation sites Thr202 and Tyr204 of the extracellular signal-regulated kinase 1/2 (ERK1/2) proteins. It is used to detect the activation state of these important signaling proteins.
Automatically generated - may contain errors
Lab products found in correlation
Erk1 2, by Cell Signaling Technology (2 mentions)
Ser473 akt, by Cell Signaling Technology (2 mentions)
D mannitol, by Merck Group (1 mentions)
Ag 1024, by Selleck Chemicals (1 mentions)
Irs 1, by Cell Signaling Technology (1 mentions)
Igf 1r sirna, by Cell Signaling Technology (1 mentions)
Irdye 800cw, by LI COR (1 mentions)
Total igf1r, by Cell Signaling Technology (1 mentions)
Orlistat, by Merck Group (1 mentions)
Ibrutinib, by Selleck Chemicals (1 mentions)
Bez235, by Selleck Chemicals (1 mentions)
Mln4924, by Chemietek (1 mentions)
Bkm120, by Selleck Chemicals (1 mentions)
Cd79a, by Cell Signaling Technology (1 mentions)
Cycloheximide (chx), by Merck Group (1 mentions)
Gapdh, by Cell Signaling Technology (1 mentions)
Mcl 1, by Cell Signaling Technology (1 mentions)
Temsirolimus, by Merck Group (1 mentions)
Ly294002, by Selleck Chemicals (1 mentions)
Bortezomib, by Selleck Chemicals (1 mentions)
2 protocols using thr202 tyr204 erk1 2
1
Evaluating IGF-1R Signaling Pathways
2
Comprehensive Signaling Pathway Profiling
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(Ser473)-Akt, (Ser235/236)-S6, (Ser32/36)-IκB, (Thr202/Tyr204)-Erk1/2, Akt, S6, Erk1/2, IκB, p65, CD79A, Mcl1 and GAPDH antibodies were purchased from Cell Signaling, Danvers, MA, USA. Anti-NOXA was obtained from Calbiochem, La Jolla, CA, USA. Bez235, Ibrutinib, PD0325901, MG132, Bortezomib, LY294002 and BKM120 were obtained from Selleckchem, Houston, TX, USA. Temsirolimus, Orlistat and cycloheximide were purchased from Sigma, Munich, Germany. MLN4924 was obtained from ChemieTek, Indianapolis, IN, USA.
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