Ge optima

Paraspinal CT measurements for each older adult undergoing treatment were obtained from their medical records from routine non-contrast CT of the chest. We used axial images localized to the twelfth thoracic vertebrae (T12) in CT image analyses in Osirix MD (Pixmeo, Bernex, Switzerland). We placed 2 cm² ovoid ROIs in the erector spinae muscles bilaterally and the Hounsfield units (HU) were averaged to obtain erector spinae HU (see Figure 1). If the available erector spinae areas were <2 cm², the largest available region of interest was used. Eight CT scans were non-contrast, and two had early arterial phase contrast. CT scanners used were GE Revolution HD (n = 4), GE Revolution EVO (n = 3), and GE Optima (n = 3) (GE Healthcare, Madison, WI) and all but 1 scan was conducted at the University of Wisconsin Health Hospital in Madison, WI.

The ABR was recorded from 70 dB nHL down to threshold or 20 dB nHL minimum, and up to a maximum of 80 dB nHL for the NE, and 90 dB nHL for the IE (100 µs rarefaction clicks, repetition rate 39 Hz, insert earphones, Eclipse EP25 (program version 4.3.0.17, Interacoustics, Middelfart, Denmark)) [20 (link),25 (link)]. For a full description of measurements and results see [20 (link)].
Tests of the cCMV infection were based on Polymerase chain reaction (PCR) analysis on the dried blood spot (DBS) cards typically taken 48 h after birth (n = 16), plasma test on the same day as birth (n = 1), or the mother’s lgG and lgM negative CMV blood test 51–88 days after birth (n = 3). For a full description of measurements and results see [20 (link)].
Fourteen subjects underwent MRI (19 eligible, 5 out of 19 subjects declined [20 (link)]). Thirteen MRI scans were performed with 3T scanners (Siemens Skyra or Siemens Prisma, Erlangen, Germany), and one with a 1.5 T scanner due to a combined spine MRI scan (GE Optima, GE Healthcare, Fairfield, CT, USA). Standard clinical protocols were used (see details in [20 (link)].

The average interval between baseline imaging and infusion was four months (range 0.4 to 11.5 months). Follow-up imaging was performed on average 11.9 months (range 11 to 13 months) after infusion [23 (link)]. The MRI equipment of the baseline imaging included five 1.5 T units (GE Signa Twinspeed, General Electric Medical Systems, Milwaukee, WI, USA; Philips Achieva and Philips Intera, Philips Medical Systems, Eindhoven, The Netherlands; Siemens Avanto and Siemens Espree, Siemens Medical, Erlangen, Germany), a 0.34 T unit (Siemens Magnetom C, Siemens Medical, Erlangen, Germany) and a 0.23 T unit (Philips Panorama, Philips Medical Systems, Eindhoven, The Netherlands). The imaging sequences were sagittal T1-weighted (T1 W) turbo spin-echo (TSE) or fast spin-echo (FSE) with fluid attenuation inversion recovery (FLAIR), sagittal T2-weighted (T2 W) TSE/FSE, and short tau inversion recovery sequences (STIR). The specific imaging parameters have been described previously [23 (link)]. The MRI equipment of the one-year follow-up imaging included two 1.5 T units (GE Signa Twinspeed and GE Optima, General Electric Medical Systems, Milwaukee, WI, USA) and a 3 T unit (Siemens Skyra, Siemens Medical, Erlangen, Germany). Imaging protocols were established for clinical spine imaging.