The radiolabeling of 68 Ga-PSMA-617 and 177Lu-EB-PSMA-617 was conducted as previously described [27 (link)]. 18F-FDG was synthesized in-house with an 11-MeV cyclotron (CTI RDS 111; Siemens).
Cti rds 111
Manufactured by Siemens
Sourced in Germany
The CTI RDS 111 is a laboratory equipment product designed for research and development applications. It is a compact and versatile device that offers precise temperature control capabilities. The core function of the CTI RDS 111 is to provide accurate and consistent temperature regulation for various experimental setups.
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Lab products found in correlation
5 protocols using cti rds 111
1
Radiolabeling of PSMA-617 and FDG
2
Radiolabeling and PET/CT Imaging Protocols
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The DOTA-CPCR4-2 peptide was purchased from CSBio Co (CA 94025, USA). The radiolabeling of 68Ga-pentixafor was performed manually before injection according to the procedures as previously published. 18F-FDG was synthesized in house with an 11 MeV cyclotron (CTI RDS 111, Siemens, Germany). The PET scans were performed with dedicated PET/CT scanners (Biograph 64 Truepoint TrueV, Siemens, Germany; Polestar m660, SinoUnion, China) from the tip of the skull to the middle thigh. For 18F-FDG PET/CT, the patients fasted for at least 6 h, and the blood glucose levels were monitored (4.7–6.9 mmol/L) before an injection of 18F-FDG (5.55 MBq/kg). The PET/CT images (2 min/bed) were acquired with an uptake time of 75.0 ± 13.2 (mean ± SD) min. For 68Ga-pentixafor PET/CT, imaging was performed (2–4 min/bed) with an uptake time of 45.9 ± 19.7 min after an injection of 85.1 ± 27.4 MBq of 68Ga-pentixafor. The acquired data were reconstructed using the ordered-subset expectation maximization method (Biograph 64: 2 iterations, 8 subsets, Gaussian filter, image size of 168 × 168; Polestar m660: 2 iterations, 10 subsets, Gaussian filter, image size of 192 × 192).
3
Radiolabeling and PET/CT Imaging Procedures
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The DOTA-FAPI-04 peptide was purchased from CSBio Co (Menlo Park, CA). The radiolabeling of [68 Ga]Ga-FAPI-04 was performed manually before injection according to the procedures as previously published [22 (link)]. [18F]FDG was synthesized in-house with an 11 MeV cyclotron (CTI RDS 111, Siemens, Germany). The PET scans were performed on dedicated PET/CT scanners (Biograph 64 Truepoint TrueV, Siemens, Germany; Polestar m660, SinoUnion, China). For [18F]FDG PET/CT, the patients fasted for over 6 h, and the blood glucose levels were monitored (4.5–7.8 mmol/L) prior to an injection of [18F]FDG (5.55 MBq/kg). The PET/CT images (2 min/bed) were acquired with an uptake time of 75.6 ± 15.1 min. For [68 Ga]Ga-FAPI-04 PET/CT, imaging was performed (2 min/bed) with an uptake time of 51.2 ± 13.2 min after an injection of 103.6 ± 33.3 MBq [68 Ga]Ga-FAPI-04. The PET/CT scan was obtained from the tip of the skull to the crus. The acquired data were reconstructed using the ordered-subset expectation maximization method.
4
Multimodal PET Imaging of CXCR4 Expression
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The DOTA-CPCR4-2 peptide was purchased from CSBio Co (CA 94025, USA). The radiolabeling of [68Ga]pentixafor was performed manually before injection according to the procedures as previously published [8 (link)]. [18F]FDG was synthesized in house with an 11 MeV cyclotron (CTI RDS 111, Siemens, Germany).
The PET scans were performed on dedicated PET/CT scanners (Biograph64 Truepoint TrueV, Siemens, Germany; Polestar m660, SinoUnion, China) from the tip of the skull to the middle thigh. For [18F]FDG PET/CT, patients fasted for over 6 h and the blood glucose levels were monitored (4.4–8.8 mmol/L) prior to an injection of [18F]FDG (5.55 MBq/kg). The PET/CT images (2 min/bed) were acquired with an uptake time of 76.0 ± 15.8 min (range 50–105 min). For [68Ga]pentixafor PET/CT, imaging was performed (2–4 min/bed) with an uptake time of 56.1 ± 22.0 min (range 30–108 min) after injection of 2.8 ± 0.9 MBq (range 1.3–5.0 MBq) [68Ga]pentixafor. All patients underwent unenhanced low-dose CT (120 kV, 30–50 mAs) for attenuation correction and anatomical reference. The acquired data were reconstructed using the ordered subset expectation maximization method (Siemens Biograph 64 2 iterations, 8 subsets, Gaussian filter, image size 168 × 168; SinoUnion Polestar 2 iterations, 10 subsets, Gaussian filter, image size 192 × 192).
The PET scans were performed on dedicated PET/CT scanners (Biograph64 Truepoint TrueV, Siemens, Germany; Polestar m660, SinoUnion, China) from the tip of the skull to the middle thigh. For [18F]FDG PET/CT, patients fasted for over 6 h and the blood glucose levels were monitored (4.4–8.8 mmol/L) prior to an injection of [18F]FDG (5.55 MBq/kg). The PET/CT images (2 min/bed) were acquired with an uptake time of 76.0 ± 15.8 min (range 50–105 min). For [68Ga]pentixafor PET/CT, imaging was performed (2–4 min/bed) with an uptake time of 56.1 ± 22.0 min (range 30–108 min) after injection of 2.8 ± 0.9 MBq (range 1.3–5.0 MBq) [68Ga]pentixafor. All patients underwent unenhanced low-dose CT (120 kV, 30–50 mAs) for attenuation correction and anatomical reference. The acquired data were reconstructed using the ordered subset expectation maximization method (Siemens Biograph 64 2 iterations, 8 subsets, Gaussian filter, image size 168 × 168; SinoUnion Polestar 2 iterations, 10 subsets, Gaussian filter, image size 192 × 192).
5
18F-FDG PET/CT Imaging Protocol
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F was generated through an 11-MeV cyclotron (CTI RDS 111; Siemens), and FDG was labeled with 18 F in an automated process to synthesize 18 F-FDG. Patients fasted for more than 6 h before injection, and blood glucose was monitored to guarantee the quality of the images. Then 18 F-FDG was injected at a dose of 5.55 MBq/kg, after which patients waited 60 min for uptake.
The images were acquired on PET/CT scanners (Polestar m660 [SinoUnion] or Biograph 64 TruePoint TrueV [Siemens]) after a stable distribution of radiotracers. First, a topogram was obtained to determine the scan range, which was set between the top of the skull and the feet. Then low-dose CT was performed for each patient. The CT images were used to provide anatomic information as well as attenuation correction. Next, the PET images were acquired at a speed of 2 min/bed position. Finally, the images were reconstructed through an ordered-subset expectation maximization, which was set to 8 subsets, 2 iterations, a gaussian filter of 5 mm in full width at half maximum, and a 168 3 168 image size for the Siemens Biograph 64 and 10 subsets, 2 iterations, a gaussian filter of 4 mm in full width at half maximum, and a 192 3 192 image size for the SinoUnion Polestar.
The images were acquired on PET/CT scanners (Polestar m660 [SinoUnion] or Biograph 64 TruePoint TrueV [Siemens]) after a stable distribution of radiotracers. First, a topogram was obtained to determine the scan range, which was set between the top of the skull and the feet. Then low-dose CT was performed for each patient. The CT images were used to provide anatomic information as well as attenuation correction. Next, the PET images were acquired at a speed of 2 min/bed position. Finally, the images were reconstructed through an ordered-subset expectation maximization, which was set to 8 subsets, 2 iterations, a gaussian filter of 5 mm in full width at half maximum, and a 168 3 168 image size for the Siemens Biograph 64 and 10 subsets, 2 iterations, a gaussian filter of 4 mm in full width at half maximum, and a 192 3 192 image size for the SinoUnion Polestar.
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