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Quinidine

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Sourced in China

Quinidine is a chemical compound used as a laboratory reagent. It functions as a cardiac antiarrhythmic agent, primarily utilized for its effects on the cardiovascular system. The core function of quinidine is to modulate the electrical activity of the heart.

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Lab products found in correlation

Ofloxacin, by MedChemExpress (2 mentions) Lamotrigine, by MedChemExpress (2 mentions) Digoxin, by MedChemExpress (2 mentions) Atenolol, by MedChemExpress (2 mentions) Carbamazepine, by MedChemExpress (2 mentions) Propranolol, by MedChemExpress (2 mentions) Diltiazem, by MedChemExpress (2 mentions) Fexofenadine, by Tokyo Chemical Industry (2 mentions) Antipyrine, by MedChemExpress (2 mentions) Western blocking buffer, by Beyotime (1 mentions) Metformin hydrochloride, by MedChemExpress (1 mentions) Phorbol 12 myristate 13 acetate, by MedChemExpress (1 mentions) Ab34710, by Abcam (1 mentions) Opn ab8448, by Abcam (1 mentions) Ml385, by MedChemExpress (1 mentions) Ripa buffer, by Beyotime (1 mentions) β actin, by Proteintech (1 mentions) Bca kit, by Beyotime (1 mentions) Ab5694, by Abcam (1 mentions) H2dcfda, by Beyotime (1 mentions)

4 protocols using quinidine

1

TGF-β2 Cytokine Modulation of Cellular Pathways

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The TGF-β2 cytokine was purchased from Pepro Tech. Glyceraldehyde-3-phosphatedehydrogenase (GAPDH), horseradish peroxidase (HRP)-conjugated secondary antibodies, RIPA buffer, H2DCF-DA, BCA kit, western blocking buffer, H2DCF-DA were the products of Beyotime (China). The nucleoside 5-aminoimidazole-4-carboxamide riboside (AICAR), metformin hydrochloride, Phorbol 12-myristate 13-acetate (PMA), ML385 (an Nrf2 inhibitor) (CAS No.: 846557-71-9), Atropine (CAS No.: 51-55-8) and Quinidine (CAS No.: 56-54-2) were acquired from MedChemExpress (MCE) (China). Antibodies against AKT, p-AKT, AMPK and p-AMPK (172) were purchased from CST. Antibodies against superoxide dismutase 1 (SOD1), SOD2, γ-glutamyl cysteine synthetase (γ-GCS), Catalase (CAT), smad2/3 and β-actin were purchased from Proteintech. Antibodies against Nrf2, α-smooth muscle actin (α-SMA) (ab5694), Osteopontin (OPN) (ab8448), collagen-I, p-smad2/3 and fibronectin (ab34710) were purchased from Abcam. Antibody against p-Nrf2(S40) was provided by Santa Cruz Biotechnology. The cell culture reagents were the products of Gibco Laboratories (CAS No.:16000-044).
Li X., Leng Y., Jiang Q., Wang Z., Luo P., Zhang C., Chen L., Wang Y., Wang H., Yue X., Shen C., Zhou Y., Shi C, & Xie L. (2020). Eye Drops of Metformin Prevents Fibrosis After Glaucoma Filtration Surgery in Rats via Activating AMPK/Nrf2 Signaling Pathway. Frontiers in Pharmacology, 11, 1038.
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2

Investigation of Botanical Bioactive Compounds

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Diester diterpenoid alkaloids (DDAs) and monoester diterpenoid alkaloids (MDAs), including aconitine (AC), mesaconitine (MA), hypaconitine (HA), benzoylaconitine (BAC), benzoylmesaconitine (BMA), and benzoylhypaconitine (BHA), liquiritin, liquiritigenin, licochalcone A, isoliquiritin, isoliquiritigenin and glycyrrhetinic acid were purchased from Vientiane Hengyuan Tech Co., Ltd (China), while glycyrrhizic acid was obtained from Solarbio Science & Technology Co., Ltd (China). Rifampin and quinidine were obtained from MedChem Express Co., Ltd (China). The purity of the testing chemicals was authenticated by HPLC. HPLC grade acetonitrile and formic acid for liquid chromatography were purchased from Fisher Scientific (USA). Fetal bovine serum (FBS) was purchased from Lanzhou Minhai Bio-Engineering Co., Ltd (Lanzhou, China). Dulbecco's modified Eagle's medium (DMEM) with 4.5 g L−1 glucose and GlutaMAX™ were from Hyclone. Phosphate-buffered saline solution (PBS) and antibiotic (10 000 U mL−1 penicillin, 10 000 μg mL−1 streptomycin) were from Solarbio Science & Technology Co., Ltd (Beijing, China). The 3H-estrone sulfate (3H-ES), 3H-estradiol glucuronide (3H-EG), 14C-tetraethylammonium (14C-TEA) and 14C-para-aminohippuric acid (14C-PAH) were all obtained from American Radiolabeled Chemicals Incorporation (St. Louis, USA).
He Y., Wang Z., Wu W., Xie Y., Wei Z., Yi X., Zeng Y., Li Y, & Liu C. (2019). Identification of key transporters mediating uptake of aconitum alkaloids into the liver and kidneys and the potential mechanism of detoxification by active ingredients of liquorice. RSC Advances, 9(28), 16136-16146.
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3

Comparative Physicochemical Characterization

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In this study, 14 compounds with different physiochemical properties were selected. Antipyrine, ofloxacin, lamotrigine, digoxin, quinidine, atenolol, carbamazepine, propranolol, diltiazem, memantine, diphenhydramine, pyrilamine, and gabapentin were purchased from MedChemExpress (Monmouth Junction). Fexofenadine was purchased from Tokyo Chemical Industry. The other chemicals and reagents were of the HPLC grade or better.
Wang S., Chen C., Guan C., Qiu L., Zhang L., Zhang S., Zhou H., Du H., Li C., Wu Y., Chang H, & Wang T. (2021). Effects of membrane transport activity and cell metabolism on the unbound drug concentrations in the skeletal muscle and liver of drugs: A microdialysis study in rats. Pharmacology Research & Perspectives, 9(5), e00879.
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4

Physicochemical Characterization of Diverse Compounds

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In all, 18 compounds with different physiochemical properties were selected for this study. Antipyrine, ganciclovir, ofloxacin, 4‐aminoAntipyrine, lamotrigine, theophylline, citalopram, digoxin, quinidine, pemetrexed, atenolol, carbamazepine, propranolol, and diltiazem were purchased from MedChemExpress (Monmouth Junction). Acetaminophen was purchased from Sigma‐Aldrich. Fexofenadine and sumatriptan were purchased from Tokyo Chemical Industry. Cimetidine was purchased from National Institute for the Control of Pharmaceutical and Biological Products. All the other chemicals were of the HPLC grade or better.
Chen C., Zhou H., Guan C., Zhang H., Li Y., Jiang X., Dong Z., Tao Y., Du J., Wang S., Zhang T., Du N., Guo J., Wu Y., Song Z., Luan H., Wang Y., Du H., Zhang S., Li C., Chang H, & Wang T. (2020). Applicability of free drug hypothesis to drugs with good membrane permeability that are not efflux transporter substrates: A microdialysis study in rats. Pharmacology Research & Perspectives, 8(2), e00575.
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