The BRCA data were downloaded from the cBioPortal for Cancer Genomics (https://www.cbioportal.org )65 (link). It contained the METABRIC BRCA cohort assembled from 2509 primary breast cancer patients with 548 matched normals in the United Kingdom and Canada13 (link). The gene expression microarray data were generated using the Illumina Human v3 microarray for 1904 samples, while the CNVs data were measured on the Affymetrix SNP 6.0 platform for 2173 samples. In addition, 17,272 somatic mutations of 173 genes for 2369 samples were detected on the Illumina HiSeq 2000 platform. R scripts responsible for the work's implementation are provided in the Github repositories (https://github.com/hauldhut/drivergene ) (See more detail in Supplementary File 1 ).
All omics data we pre-processed in the same way as in the reference paper13 (link). Specifically, we only matched the sample labels shared between the gene expression data and clinical data, and the CNVs data and clinical data, and obtained 1904 and 2173 matched patients, respectively.
All omics data we pre-processed in the same way as in the reference paper13 (link). Specifically, we only matched the sample labels shared between the gene expression data and clinical data, and the CNVs data and clinical data, and obtained 1904 and 2173 matched patients, respectively.