U73122 1268

Manufactured by Bio-Techne

U73122 (1268) is a laboratory reagent produced by Bio-Techne. It is a phospholipase C inhibitor. The core function of this product is to inhibit phospholipase C activity in experimental settings.

Automatically generated - may contain errors

Lab products found in correlation

Xestospongin c, by Bio-Techne (1 mentions) Fr900359, by Cayman Chemical (1 mentions) Sq22536, by Bio-Techne (1 mentions) Recombinant mouse m csf, by Thermo Fisher Scientific (1 mentions) L serine, by Merck Group (1 mentions)

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U73122 (101 citations)

2 protocols using u73122 1268

Cellular Signaling Pathway Modulation

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Forskolin (F6886), IBMX (I7018), LRE1 (SML1857), 8-Br-cAMP (B7880), BrdU (B5002), dynasore (D7693), (−)-isoproterenol (I6504), barbadin (SML3127), BAPTA-AM (A1076), ionomycin (I0634), and Dowex–Alumina resins were from Sigma. Dyngo-4a (D4a; ab120689) was from Abcam. [2,8-³H]-Adenine (NET063001MC) was from Perkin Elmer. TSH (TSH-1315B) was from Creative Biomart. U73122 (1268), JTV-519 fumarate (4564), and Xestospongin C (1280) were from Tocris. FR-900359 (33666) was from Cayman Chemical. The Nano-Glo Endurazine Live Cell Substrate prototype (Fz-4377), a degradation-resistant derivative of Furimazine, was from Promega. KH7 and its inactive analog KH7.15 were provided by Drs Buck-Levin (Cornell).

Pizzoni A., Zhang X., Naim N, & Altschuler D.L. (2023). Soluble cyclase-mediated nuclear cAMP synthesis is sufficient for cell proliferation. Proceedings of the National Academy of Sciences of the United States of America, 120(4), e2208749120.

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Reagents for Signal Transduction Assays

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Trehalose (T9531), sucralose (69293), saccharin (S1002), glucose (G8270), sucrose (S0389), maltose (M5885), lactose (L254) and L‐serine (S4311) were obtained from Sigma–Aldrich. Acesulfame K was obtained from Tokyo Chem. Industry (A1490). U73122 (1268) and its inactive analogue U73433 (4133), and adenylyl cyclase inhibitor SQ22536 (1435) were from TOCRIS. Recombinant mouse M‐CSF was purchased from Peprotech (315‐02).

Lee J., Kim S.J., Choi G.E., Yi E., Park H.J., Choi W.S., Jang Y.J, & Kim H.S. (2022). Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation linked to autophagy deficiency in myeloid cells. Clinical and Translational Medicine, 12(8), e1021.

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