Rhodamine 123 rh123

Mesoporous silica dispersion was purchased from nanoComposix Company (USA), and Isoimperatorin from DESITE (China). Fetal bovine serum and RPMI1640 cell culture medium were extracted by Gibco (USA). Cell counting kit-8 (CCK-8) was purchased from Dojindo laboratories (Japan), and the Annexin V-FITC/PI apoptosis detection reagent was produced by BD (USA). Cell cycle detection kit, reactive oxygen species (ROS) detection kit, and DAPI were acquired from Beyotime Biotechnology (China). Rhodamine 123 (Rh123) was provided by Yeasen Biotechnology (China). Cy5 and membrane (2 kD) were purchased from Solarbio (China). Cell lysate, Protease inhibitor and TUNEL reaction solution were obtained from Boster (China). Anti-Ki-67, anti-P53, anti-Caspase-9 and anti-Caspase-3 antibodies were all purchased from Servicebio (China), while anti-Pan-Cadherin and anti-E-Cadherin antibodies were acquired from CST (USA). H&E staining kit was purchased from keygen BioTECH (Chnia), and human lymphoma cell line OCI-LY10 was acquired from the Shanghai Institute of Cell Research, Chinese Academy of Sciences.

Zirconia nanoparticle (XF101) was purchased from XFNANO Materials Tech Co., Ltd. (China). NAC was purchased from Sigma Aldrich (United States). MTT cell proliferation and cytotoxicity assay kit was purchased from Beyotime Biotechnology. Rhodamine 123 (Rh123) was obtained from Yeasen Biotechnology (China). Annexin V-FITC/PI Apoptosis Detection Kit, MMP Detection Kit (JC-1), and ROS Assay Kit were purchased from KeyGEN BioTECH (China). BCA Protein Assay Kit was purchased from Solarbio science and technology Co., Ltd. (China). DMEM-HG (high glucose), fetal bovine serum (FBS), and trypsin were purchased from Life Technologies (United States). BBoxiProbe^® superoxide anion detection kit, Singlet oxygen detection kit were from Shanghai Bestbio Biotechnology Co., Ltd. (China). Hydroxyl radical in situ fluorescence staining kit was from Shanghai Haling Biological Technology Co., Ltd. (China). One Step TUNEL Apoptosis Assay Kit, Ki-67 cell proliferation Detection Kit (IHC), DAPI and hematoxylin and eosin (HE) were purchased from Servicebio Tech Co., Ltd. (China). Anti-Bax, anti-Bcl-2, anti-Caspase-9, anti-Caspase-3, anti-Cytochrome C, anti-LC3, anti-Atg12, anti-Atg5, anti-Beclin-1, anti-β-actin antibodies, and horseradish peroxidase (HRP) goat anti-mouse and goat anti-rabbit IgG secondary antibodies were produced by Proteintech (United States).