Methanol

Among the reagents used in the reaction and analysis, ISB was procured from Roquette Frères (Lestrem, France) and used after recrystallization in acetone, 4,4′-difluorobenzophenone (FBP, 99%) and 4,4′-dichlorobenzophenone (CBP, 99%) were purchased from TCI (Tokyo, Japan) and used after recrystallization in Methanol. Potassium carbonate (K₂CO₃, 99%) was purchased from Sigma-Aldrich Corp. (St. Louis, MO, USA) and used after grinding into fine particles and drying in a vacuum oven together with phosphorus pentoxide, 18-crown-6 (18C6, 99%), dimethyl sulfoxide (DMSO, 99%), N,N-dimethlacetamide (DMAc, 99%), 1-methyl-2-pyrrolidinone (NMP, 99%), sulfolane (99%), toluene (99.5%), acetic acid (99%), chloroform (HPLC, 99.9%), and polyethylene glycol (PEG, 400 g/mol) were purchased from Aldrich. Methanol was purchased from Daejung Chemical (Gyeonggi-do, Korea), Commercial PSU was procured from BASF (Ludwigshafen, Germany). All chemicals were used without further purification unless stated.

Soy phosphatidylcholine (soy-PC; lecithin from soybean) was purchased from Ilshin wells (Seoul, Korea). Cholesterol (CH; > 99% purity), trehalose dihydrate, sucrose, and calcein were purchased from Sigma-Aldrich Co. (St. Louis, MO, USA). 1,6-Diphenyl-1,3,5-hexatriene (DPH) and 6-dodecanoyl-N,N-dimethyl-2-naphthylamine (Laurdan) were acquired from Molecular Probes (Eugene, OR, USA). Acetone, methanol, 1-propanol, and isopropanol (IPA) were purchased from Daejung (Siheung, Gyeonggi-do, Korea). All other chemicals were obtained from Sigma-Aldrich Co. and used without further purification.

Fe(III) chloride hexahydrate (FeCl₃·6H₂O; 98%), 2‐aminoterephthalic acid (BDC‐NH₂; 99%), N,N‐dimethylformamide (DMF; anhydrous, 99.8%), d‐penicillamine (d‐pen; 98%–101%), 4‐chloro‐7‐nitrobenzofurazan (NBD‐CL; 98%), copper(II) sulfate (CuSO₄; >99%), formic acid (>98%) and 2′‐7′‐dichlorofluorescein diacetate (DCFH‐DA) were purchased from Sigma‐Aldrich (St. Louis, MO, USA). Methanol (>96%), ethanol (>96%), ammonium acetate (98%), sodium borate (Na₂B₄O₇), and hydrogen peroxide (H₂O₂; 30%–35%) were obtained from Daejung Chemicals (Siheung, Korea). 3,3′,5,5′‐Tetramethylbenzidine (TMB; >98%) and acetonitrile (ACN, 99.9%) were purchased from TCI (Chuo‐ku, Japan) and J.T. Bakers (Pittsburgh, PA, USA), respectively. Irinotecan (CPT‐11; >99%) was obtained from LC Laboratories (Woburn, MA, USA). Phosphate‐buffered saline (PBS, pH 7.4) and Dulbecco's Modified Eagle's Medium (DMEM) were obtained from the Seoul National University Biomedical Research Institute (Seoul, Korea) and Welgene (Gyeongsan, Korea), respectively. Fetal bovine serum (FBS) and penicillin–streptomycin (10,000 U/ml) were purchased from Thermo Fisher Scientific (Waltham, MA, USA).

2-Acrylamido-2-methyl-1-propanesulfonic acid (AMPS), poly(1,4-phenylene ether-ether-sulfone) (PEES), TiCl₃·AA and AlEt₂Cl ([25 (link)] wt% in toluene) were purchased from Sigma-Aldrich (St. Louis, MO, USA). Methanol, acetone, N,N-dimethylacetamide (DMAc), N,N-dimethylformamide (DMF), tetrahydrofuran (THF), N-methylpyrrolidone (NMP), dimethyl sulfoxide (DMSO), sulfuric acid (H₂SO₄), were purchased from Daejung Reagents & Chemicals (Korea).

Fluoranthene, phenanthrene, naphthalene, and silica gel (70‐230 mesh ASTM) were obtained from Merck. Fluorene and pyrene from Hopkin Williams LTD, whereas acenaphthalene, benzopyrene, and anthracene were bought from BDH. HPLC grade solvents, like n‐hexane, dichloromethane, and acetonitrile, were purchased from Samchun. Potassium hydroxide was bought from Scharlau while methanol and anhydrous sodium sulfate from Daejung. Rabbit meat was bought from the local market of Faisalabad, Pakistan.