Cobas integra analyzer

Manufactured by Roche

Sourced in United States, Switzerland

The Cobas Integra analyzer is a diagnostic instrument developed by Roche for use in clinical laboratories. It is designed to perform a variety of clinical chemistry and immunochemistry tests. The Cobas Integra analyzer automates sample handling, analysis, and data management to provide efficient and reliable test results.

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Spelling variants of this product

Cobas analyzer (113 citations) Cobas Integra (65 citations) Cobas Integra 800 Analyzer (18 citations) Cobas Integra 400/800 analyzer (3 citations) COBAS INTEGRA 400 plus/800 analyzers (2 citations) Cobas Integra 400/400 plus 800 analyzers (2 citations) COBAS INTEGRA 800 Plus Analyzer (2 citations) COBAS Integra II clinical analyzer (2 citations) Cobas Integra 400 Clinical Analyzer (2 citations) COBAS INTEGRA 800 Biochemistry analyzer (2 citations)

21 protocols using cobas integra analyzer

Baseline Fasting Blood Lipid Analysis

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At baseline, fasting blood samples were collected and stored in aliquots at −80°C. Serum lipids and fasting glucose (GLU) were measured enzymatically with a Cobas Integra Roche analyzer (Roche, Indianapolis, IN)

Yang J., Cheng N., Zhang Y., Ye L., Li J., Zhou Z., Wang Z., Liu L., Huang X., Liang X., Ling T., Xu Y., Song Y., Wang B., Tang G., Qin X., Zalloua P., Zhang H., Yan F, & Xu X. (2021). Inverse association between body mass index and all-cause mortality in rural chinese adults: 15-year follow-up of the Anqing cohort study. BMJ Open, 11(8), e045495.

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Fasting Lipid and Glucose Measurement

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At baseline, fasting blood samples were collected and stored in aliquots at − 80 °C. Serum lipids and fasting blood glucose were measured enzymatically with a Cobas Integra Roche analyzer (Roche, Indianapolis, IN).

Cheng N., Zhang Y., Yang J., Li J., Ye L., Zhou Z., Wang Z., Liu L., Song Y., Yang Z., She G., Bai X., Huang X., Cheng X., Tang G., Wang B., Qin X., Zalloua P., Yan F, & Xu X. (2020). Association Between Fasting Blood Glucose and All-Cause Mortality in a Rural Chinese Population: 15-Year Follow-Up Cohort Study. Diabetes Therapy, 11(11), 2691-2701.

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Fasting Biomarker Measurement Protocol

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Fasting blood samples at baseline and at the exit visit were collected from each participant to measure fasting blood glucose and serum lipids (total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C)). Samples were stored in aliquots at − 80 °C and enzymatic measurements were analyzed using a Cobas Integra Roche analyzer (Roche, Indianapolis, IN).

Liu J., Cheng N.N., Zhou Z.Y., Zhang Y., Yang J., Liu L.S., Song Y., Huang X., Tang G.F., Wang B.Y., Qin X.H., Xu X.P, & Kong X.Q. (2021). Effect of fasting blood glucose on risk of new‐onset hypertension in rural Chinese population: a 15-year follow-up cohort. BMC Cardiovascular Disorders, 21, 531.

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Plasma Lipid and Enzyme Measurements

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Glucose, triglyceride and total cholesterol concentrations were determined with BIOSYSTEM kits (Barcelona, Spain) in plasma samples, according to manufacturer’s instructions. Plasma were used for the assay of lipoproteins on agarose gel by the method of Kalwakami [16 (link)]. Plasma creatine Phosphokinase (CPK) levels were measured using COBAS INTEGRA Analyzer (Roche; CA, USA).

Sahraoui A., Dewachter C., Vegh G., Mc Entee K., Naeije R., Bouguerra S.A, & Dewachter L. (2020). High fat diet altered cardiac metabolic gene profile in Psammomys obesus gerbils. Lipids in Health and Disease, 19, 123.

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Serum Biomarkers in Schoolchildren

Cited 1 time

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Serum vitamin 25(OH)D level, CK and LDH activities, and Ca and sBAP concentrations were estimated in serum freshly separated from blood samples of each schoolchild as mentioned previously.55 (link),56 (link) Vitamin 25(OH)D levels were estimated in serum samples using immunoassay kits (IDS, Tyne & Wear, UK). Serum CK and LDH activities were measured using available enzymatic assays (Granutest 15; EMD Millipore, Billerica, MA, USA) and ultraviolet assays (Randox Laboratories Ltd., Antrim, UK). Colorimetric assays using Cobas Integra® analyzer and available kits (Hoffmann-La Roche Ltd., Basel, Switzerland) were used to determine Ca levels in serum. sBAP concentrations (U/L) were measured in serum using the MicroVue BAP immunoenzymometric assay (Quidel Corporation, San Diego, CA, USA).55 (link),56 (link)

Alghadir A.H., Gabr S.A, & Al-Eisa E.S. (2017). Mechanical factors and vitamin D deficiency in schoolchildren with low back pain: biochemical and cross-sectional survey analysis. Journal of Pain Research, 10, 855-865.

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Fasting Blood Biomarker Assessment

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In summary, blood samples were obtained from three examination sites (the University of Wisconsin, University of California, Los Angeles and Georgetown University). All participants underwent fasting blood sampling before breakfast, and these blood samples were analyzed in the MIDUS Biocore Lab. The glycated hemoglobin assays were performed at Meriter Labs (Madison, WI) using a Cobas Integra analyzer (Roche Diagnostics, Indianapolis, IN). See Ryff and colleagues for more details about the assessment of these blood biomarkers.

Huang Y., Chen H., Hu D, & Wan R. (2022). Blood hemoglobin A1c might predict adverse differences in heart rate variability in a diabetic population: Evidence from the Midlife in the United States (MIDUS) study. Frontiers in Endocrinology, 13, 921287.

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Plasma Selenium and Inflammation Markers

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Plasma selenium concentration was measured by inductively coupled mass spectrometry (ICP-MS; Agilent 7700, Agilent Technologies, Inc) as described previously (8 ). Baseline and endline plasma samples were analyzed separately. A cutoff value of <1 µmol/L was used to define inadequate selenium status (13 (link)).
Plasma concentrations of C-reactive protein (CRP) and α₁-acid glycoprotein (AGP) were measured by immunoassay using a COBAS Integra Analyzer (Roche Diagnostics). Cutoff values for plasma markers of inflammation were CRP >5 mg/L and AGP >1 g/L.

Haskell M.J., Maleta K., Arnold C.D., Jorgensen J.M., Fan Y.M., Ashorn U., Matchado A., Monangi N.K., Zhang G., Xu H., Belling E., Landero J., Chappell J., Muglia L.J., Hallman M., Ashorn P, & Dewey K.G. (2022). Provision of Small-Quantity Lipid-Based Nutrient Supplements Increases Plasma Selenium Concentration in Pregnant Women in Malawi: A Secondary Outcome of a Randomized Controlled Trial. Current Developments in Nutrition, 6(3), nzac013.

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Comprehensive Anthropometric and Metabolic Evaluation

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Anthropometric measurements were made and body mass index (BMI (kg/m²)) was calculated from weight and height. Blood pressure was measured in triplicate (HEM-705CP, Omron), and the average of the readings was calculated. Blood was drawn and processed after an overnight fast, and serum and plasma samples were stored at −70°C for subsequent analysis. Full blood count, lipid and glucose level measurements were made with standard biochemistry assays and C reactive protein (CRP) was measured with an immunoturbidimetric, high-sensitivity assay (Tina-quant assay performed on a Cobas Integra analyzer, Roche Diagnostics).

O'Neill F., Charakida M., Topham E., McLoughlin E., Patel N., Sutill E., Kay C.W., D'Aiuto F., Landmesser U., Taylor P.C, & Deanfield J. (2016). Anti-inflammatory treatment improves high-density lipoprotein function in rheumatoid arthritis. Heart, 103(10), 766-773.

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Comprehensive Metabolic Profiling of Fasting Blood Samples

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After fasting for at least 12 hours, one tube of the ethylenediaminetetraacetic acid blood sample from each participant was collected for routine hematologic tests by Prodia Laboratory on Friday morning. Another two tubes of anticoagulant-free fasting blood were then collected and immediately centrifuged for 15 min at 3000 rpm before laboratory analyses. Total cholesterol, high-density lipoprotein cholesterol (HDL-C), LDL cholesterol, triglyceride (TG) levels were analyzed using an Advia 1800 Analyzer (Siemens, Germany), hemoglobin A1c (HbA1c) was measured by a Bio-Rad D10 Analyzer (Bio-Rad, Hercules, CA, USA), and immunoglobulin E (IgE) was measured using an Immulite 2000 (Siemens, Germany). Furthermore, high-sensitivity C-reactive protein (hs-CRP) was measured using a COBAS INTEGRA Analyzer (Roche Diagnostics), TNFα was detected by enzyme-linked immunosorbent assay using commercial kits (R&D System), and nitric oxide (NO) was analyzed using commercial kits (R&D System).

Ramdhan D.H., Kurniasari F., Tejamaya M., Fitri A., Indriani A., Kusumawardhani A, & Santoso M. (2020). Increase of Cardiometabolic Biomarkers Among Vehicle Inspectors Exposed to PM0.25 and Compositions. Safety and Health at Work, 12(1), 114-118.

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Plasma Lipid and Adipokine Analysis

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Plasma triglyceride and plasma cholesterol content were determined using a COBAS Integra Analyzer with the respective assay kits (Hoffman–LaRoche). Leptin concentration in plasma was determined by enzyme-linked immunosorbent assay using a kit purchased from (ALPCO Diagnostics). Nonesterified fatty acids (NEFA) were determined using the Serum/Plasma Fatty Acid Kit (cat no. SFA-5, Zen-Bio Inc., Research Triangle Park, N.C., USA).

Picklo M.J, & Thyfault J.P. (2014). Vitamin E and vitamin C do not reduce insulin sensitivity but inhibit mitochondrial protein expression in exercising obese rats. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 40(4), 343-352.

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