Signa horizon lx

Manufactured by GE Healthcare

Sourced in United States

The Signa Horizon LX is a magnetic resonance imaging (MRI) system designed and manufactured by GE Healthcare. It is a high-field MRI system that provides advanced imaging capabilities for a variety of clinical applications.

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Lab products found in correlation

Gelatin, by Merck Group (1 mentions) Dotarem, by Guerbet (1 mentions) Gadopentetate dimeglumine, by Bayer (1 mentions) Achieva, by Philips (1 mentions) Twinspeed, by GE Healthcare (1 mentions)

Spelling variants of this product

Signa LX (27 citations) Signa Horizon (21 citations) Horizon LX (2 citations) GE Signa Horizon LX (2 citations) Signa Horizon LX Echospeed system (2 citations)

12 protocols using signa horizon lx

MRI Contrast Enhancement Evaluation

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MRI tests were performed on a 1.5 T MRI scanner (Signa Horizon LX, GE Healthcare, Chicago, IL, USA). A certain amount of HA and CoHA powders were dispersed in a gelatin (Sigma Aldrich, St. Louis, MO, USA) with different concentrations and then poured into 5 mL distilled water. The sample and gelatin solution were mixed thoroughly while at 70 °C. The gelatin mixture was allowed to cool to room temperature. The T₁-weighted images were acquired using spin echo imaging sequencing with the following parameters: matrix size = 256 × 256, field of view = 180 mm × 180 mm, slice thickness = 5 mm, echo time = 26 ms, repetition time = 100 ms, number of acquisitions = 2. Color image processing was performed using ImageJ (1.51K, National Institutes of Health, Bethesda, MD, USA). The contrast-enhancing efficacy of CoHA and commercial HA were determined by its relaxation coefficient (r₂). The r₂ is calculated by the following formula (Equation (1)) [38 (link)]:

\frac{1}{T_{2}} = \frac{1}{T_{2}^{0}} + r_{2} C

where

T_{2}

is the observed relaxation time in the presence of CoHA,

T_{2}^{0}

is the relaxation rate of pure gelatin and

C

is the concentration of cobalt ion.

Lin W.C., Chuang C.C., Wang P.T, & Tang C.M. (2018). A Comparative Study on the Direct and Pulsed Current Electrodeposition of Cobalt-Substituted Hydroxyapatite for Magnetic Resonance Imaging Application. Materials, 12(1), 116.

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Brain Imaging Protocol for Structural MRI Analysis

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All brain imaging was performed at the University of California Davis (UCD) Imaging Research Center on a 1.5T GE Signa Horizon LX system, obtaining 3D T1-weighted spoiled gradient recalled echo acquisition (T1 SPGR: TR 9.1 ms, flip angle 15°, field of view 24 and slice thickness 1.5mm). MRI baseline measurements were derived as part of our in-house processing pipeline described previously (Fletcher, Carmichael, Pasternak, Maier-Hein, & DeCarli, 2014 (link); Lee et al., 2012 (link)). Briefly, structural MRI images were processed to remove the skull using an atlas-based method and consensus-voting algorithm (Aljabar, Heckemann, Hammers, Hajnal, & Rueckert, 2009 (link); Aljabar, Heckemann, Hammers, Hajnal, & Rueckert, 2007 (link)). Human analysts provided quality control and minimal cleanup as needed. The stripped brain images were nonlinearly deformed to a minimal deformation template (MDT) synthetic image (Kochunov et al., 2001 (link)) using cubic B-spline registrations (Rueckert, Aljabar, Heckemann, Hajnal, & Hammers, 2006 ). Parameters from this transformation were later used to automatically delineate regions of interest (ROIs) in each subject native space by reverse transforming the regions from the MDT image. Lobar ROIs in MDT space were drawn by an experienced neurologist, as described previously (Lee et al., 2010 (link)).

Mungas D., Gavett B., Fletcher E., Farias S.T., DeCarli C, & Reed B. (2018). Education amplifies brain atrophy effect on cognitive decline: Implications for cognitive reserve. Neurobiology of aging, 68, 142-150.

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Pontine Infarct MRI Characterization

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Brain magnetic resonance imaging (MRI) was performed within one week of onset of infarction, including DWI, fluid-attenuated inversion recovery (coronal) and magnetic resonance angiography (MRA). Brain MRI was performed with a 1.5T scanner (Signa Horizon LX, GE, American) or a 3.0T MR scanner (Siemens, Erlangen, Germany).
PPI was defined as a lesion extending to the anterior surface of the pons, and LPI was defined as a lesion that did not extend to the anterior surface of the pons (Figure 2). Parent artery disease (PAD) was defined as patients having stenosis of basilar artery. Concomitant asymptomatic cerebral arterial atherosclerosis (ACAS), defined as any extracranial and intracranial cerebral artery atherosclerotic disease unrelated to current isolated pontine infarctions, was also assessed. The diameter of the maximally involved infarct level (axial on DWI) was evaluated as a parameter for the size of the infarct.

Yang L., Qin W., Li Y., Yang S., Gu H, & Hu W. (2020). Differentiation of Pontine Infarction by Size. Open Medicine, 15, 160-166.

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Quantitative MRI Evaluation of MNGIE

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Seven unrelated patients with a molecular diagnosis of MNGIE (3 men; age range, 23–38 years) were included in this study.
Patients were scanned on a 1.5T MR imaging system (Signa Horizon LX; GE Healthcare, Milwaukee, Wisconsin). Quantitative MR imaging parameters were compared with those obtained from 9 healthy volunteers (4 men; age range, 20–35 years) who underwent white matter ¹H-MR spectroscopy and from 14 healthy volunteers (7 men; age range, 21–43 years) who underwent diffusion tensor imaging. Patients were clinically assessed by neurologic, gastroenterologic, and nutritional evaluations. Four patients died, and in 1 patient (case 7), a postmortem examination was performed.
The Ethics Committee of S.Orsola-Malpighi Hospital approved the study, and written informed consent was obtained.

Gramegna L.L., Pisano A., Testa C., Manners D.N., D'Angelo R., Boschetti E., Giancola F., Pironi L., Caporali L., Capristo M., Valentino M.L., Plazzi G., Casali C., Dotti M.T., Cenacchi G., Hirano M., Giordano C., Parchi P., Rinaldi R., De Giorgio R., Lodi R., Carelli V, & Tonon C. (2018). Cerebral Mitochondrial Microangiopathy Leads to Leukoencephalopathy in Mitochondrial Neurogastrointestinal Encephalopathy. AJNR: American Journal of Neuroradiology, 39(3), 427-434.

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Functional MRI Acquisition Protocol

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We acquired MRI data using a neuro-optimized 1.5-T GE Signa Horizon LX scanner with a standard quadrature head coil. Functional images were acquired using a standard T2*-weighted echo-planar imaging sequence (32 ascending interleaved axial slices, 2000-ms repetition time, 30-ms echo time, 80° flip angle, 224 × 224-mm^{2 (link)} field of view, 3.5-mm thickness, 1-mm gap, and 3.5 × 3.5-mm^{2 (link)} in-plane resolution). There were two experimental blocks, 346 volumes per block.

Ye Z., Heldmann M., Slovic P, & Münte T.F. (2020). Brain imaging evidence for why we are numbed by numbers. Scientific Reports, 10, 9270.

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Quantifying Intramyocellular Lipids in Calf Muscles

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We measured the IMCL content in the resting tibialis anterior muscle at the level of the muscle belly of the calf using ¹H-MRS on a 1.5-T whole-body scanner system (Signa Horizon LX, GE Medical Systems, Milwaukee, WI) as described^{4 (link),28 (link)}.

Yokota T., Kinugawa S., Hirabayashi K., Yamato M., Takada S., Suga T., Nakano I., Fukushima A., Matsushima S., Okita K, & Tsutsui H. (2021). Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in heart failure patients. Scientific Reports, 11, 2272.

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Comprehensive MRI Protocol for Brain Imaging

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All MRI scans were obtained using a 1.5 Tesla GE-Signa Horizon LX scanner. Briefly, the MRI protocol included the following sequences: whole brain axial and coronal fluid-attenuated inversion recovery (FLAIR) sequences (TR/TE 10.000/160 ms); a sagittal T1-weighted sequence (TR/TE 300/4 ms); and an axial T2-weighted sequence (TR/TE 6,500/105 ms).

Jansen M.G., Geerligs L., Claassen J.A., Overdorp E.J., Brazil I.A., Kessels R.P, & Oosterman J.M. (2021). Positive Effects of Education on Cognitive Functioning Depend on Clinical Status and Neuropathological Severity. Frontiers in Human Neuroscience, 15, 723728.

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Axial T1-Weighted Imaging Protocol

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Imaging data were acquired using a 1.5T GE Signa Horizon LX scanner (General Electric, Milwaukee, Wisconsin, USA).An axial gradient-echo T1-weighted images were obtained, with 1.5-mm thick sections, repetition time [TR, ms] = 21.7, echo time [TE, ms] = 5.2, flip angle = 20^o, and matrix size 256x256x124).

Tascone L.D., Payne M.E., MacFall J., Azevedo D., de Castro C.C., Steffens D.C., Busatto G.F, & Bottino C.M. (2017). Cortical brain volume abnormalities associated with few or multiple neuropsychiatric symptoms in Alzheimer’s disease. PLoS ONE, 12(5), e0177169.

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Quantitative Perfusion Imaging of Xenografts and Patients

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DCE-MRI of xenograft tumors was performed at a volume of 100-800 mm 3 , using a 7.05 T Biospec bore magnet (Bruker) and a fast bolus injection of 5.0 ml/kg body weight of Gd-DOTA (Dotarem, Guerbet) (Supplementary Method S1). Totally 8 images prior to and 57 images post injection of Gd-DOTA were acquired with an axial T1-weighted spoiled gradient recalled sequence (SPGR). The images had a spatial resolution of 234x234x1000 μm 3 . The three most central tumor slices were used in the analysis.
In patients, DCE-MRI was performed at diagnosis, using a 1.5 T Signa Horizon LX tomograph (GE Medical Systems) with a pelvic phased array coil and a fast bolus injection of 0.1 mmol/kg body weight Gd-DTPA (Magnevist, Schering) (Supplementary Method S1). Totally 1-2 series prior to and 12-13 series post injection of Gd-DTPA were acquired with an axial T1weighted SPGR sequence. The images had a pixel size of 780x780 μm 2 , slice thickness of 5 mm and slice gap of 1 mm. All slices containing tumor were used in the analysis.

Hillestad T., Hompland T., Fjeldbo C.S., Skingen V.E., Salberg U.B., Aarnes E., Nilsen A., Lund K.V., Evensen T.S., Kristensen G.B., Stokke T., & Lyng H. (2020). MR Imaging Distinguishes Tumor Hypoxia Levels of Different Prognostic and Biological Significance in Cervical Cancer.

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Comprehensive CMR Protocol for ASO Patients

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CMR examinations were performed on a 1.5T scanner (Signa Horizon LX or TwinSpeed, GE Medical Systems, Milwaukee, WI, from 1998 through June 2004; and Philips Achieva, Philips Healthcare, Best, the Netherlands, since July 2005). Young patients who were unable to cooperate with the examination were imaged under general anesthesia as previously described. 9 (link) The standardized imaging protocol for ASO patients described by Fratz et al 10 was utilized. Briefly, the following sequences were acquired: (1) nongated localizing images; (2) electrocardiographically gated cine SSFP in ventricular long-and shortaxis planes, long-axis planes of the LV and right ventricular (RV) outflow tracts, and oblique planes to visualize the branch pulmonary arteries; (3) contrast-enhanced (Gadopentetate dimeglumine; Bayer HealthCare Pharmaceuticals, Wayne, NJ) or noncontrast isotropic 3D SSFP magnetic resonance angiogram for assessment of the great vessels; (4) flow measurements in the ascending aorta (AAo), main pulmonary artery (MPA), and branch pulmonary arteries; and (5) LGE imaging in ventricular long-and short-axis planes 10 to 15 minutes after contrast administration.

Shepard C.W., Germanakis I., White M.T., Powell A.J., Co-Vu J, & Geva T. (2016). Cardiovascular Magnetic Resonance Findings Late After the Arterial Switch Operation. Circulation. Cardiovascular imaging, 9(9).

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