Optima nm ct 640

Manufactured by GE Healthcare

Sourced in United States, Japan, United Kingdom

The Optima NM/CT 640 is a medical imaging system that combines nuclear medicine (NM) and computed tomography (CT) capabilities. It is designed to provide high-quality diagnostic images for a wide range of clinical applications.

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Lab products found in correlation

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17 protocols using optima nm ct 640

Three-Phase Bone Scan Protocol for Lumbar Spine Evaluation

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Three-phase bone scan protocol was used in all patients. 99mTc hydroxy diphosphonate (HDP) was administered intravenously (10 MBq/kg), and immediate angiographic phase and blood pool planar images were obtained over the lumbar spine. After a 2–3 h interval, a whole-body bone and a SPECT/CT scan of the lumbar spine were performed (GE dual-head gamma camera Optima NM/CT 640). SPECT data were acquired with a low-energy high-resolution collimator (128 × 128 matrix with body contouring). Non-diagnostic CT scans were obtained at fixed 120 kVp with 30 mAs. The SPECT data were reconstructed using an iterative reconstruction algorithm. The reconstructed attenuation-corrected SPECT data were co-registered with CT data and viewed in multiplanar projections. Sites of increased tracer uptake were considered positive for DDD or facet arthropathy according to localisation detected by CT (Fig. 1).Fig. 1

Multi-level degeneration (patient 30) seen on sagittal lumbar spine images. A T1W MRI, B T2W MRI, C SPECT/CT showing higher uptake in L2/3 level, D X-ray 6 months after surgery, E CT scan 2 years after surgery with fusion of the L2/3 intervertebral space

Kaiser R., Varga M., Lang O., Waldauf P., Vaněk P., Saur K., Beneš V, & Netuka D. (2023). Spinal fusion for single-level SPECT/CT positive lumbar degenerative disc disease: the SPINUS I study. Acta Neurochirurgica, 165(9), 2633-2640.

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SPECT/CT Imaging with Gallium-67 Citrate

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SPECT/CT was obtained with an Optima NM/CT 640 (GE Healthcare Japan, Tokyo, Japan) at 72 hours after the injection. The radiopharmaceutical used in this study was ⁶⁷Ga-citrate (⁶⁷Ga-citrate NMP, Nihon Medi-Physics, Tokyo, Japan). Each patient was administered the agent at 111 MBq with a rapid intravenous injection. The SPECT scans were acquired using medium-energy general-purpose collimation with 93, 184, and 300 keV photoenergy peaks for ⁶⁷Ga, a 128 × 128 matrix of 4.2 mm pixel size, and a total of 60 projections (30 stops) over 360° with a dwell time of 20 s/stop. Subsequent to the SPECT acquisition, a low-dose CT scan was acquired with 120 kV and 20 mA using a 512 × 512 matrix. The CT data were generated with a 2.5 mm slice thickness.

Oohashi M., Toshima H., Hayama K, & Ogura I. (2020). Gallium-67 SPECT-CT for the evaluation of head and neck: preliminary study on maximum standardised uptake value in lesions, and in the parotid and submandibular glands. Polish Journal of Radiology, 85, e224-e229.

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SPECT/CT Imaging of Technetium-99m

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SPECT/CT scans were obtained using a SPECT/CT scanner (Optima NM/CT 640, GE Healthcare, Tokyo, Japan), following our institutional protocol [14 (link)]. Patients were administered an intravenous injection of 740 MBq of technetium 99m hydroxymethylene diphosphonate (^99mTc-HMDP, Clear Bone Injectable, Nihon MediPhysics, Tokyo, Japan) prior to the SPECT acquisition.

Minami Y., Ogawa R, & Ogura I. (2022). Volumetric analysis of mandibular lesions with SPECT/CT: a pilot clinical study of maximum standardized uptake value. Polish Journal of Radiology, 87, e311-e315.

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Quantitative MIBI Scintigraphy for Tumor Assessment

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Optima NM/CT 640 (GE Healthcare, USA) or Philips Precedence 6 (Philips Medical Systems, Netherlands) was used for ^99mTc-MIBI scintigraphy. After intravenous injection of ^99mTc-MIBI (provided by Isotope & Radiation Co., Ltd., Beijing, China; adult dose: 740 MBq, children dose: 250 µCi/kg), early and delayed planar images were acquired at 15 min and 90 min, respectively. In addition to visual analysis, the region of interest (ROI) around the lesion was drawn manually, and an identical ROI was placed on the contralateral normal limb as a background (Fig. 1) for the image analysis. The tumor to background ratio (T/B) was calculated on the mean counts according to the ROIs. Tumor MIBI washout rate (WR) was measured on pre-chemotherapy imaging, by using the following formula: WR(%) = 

\frac{T / B 15 min - T / B 90 min}{T / B 15 min}

 × 100. Tumor alteration rate (AR) of T/B value was calculated based on the pre-chemotherapy and post-chemotherapy images.Fig. 1

ROIs of the tumor and the background.

Fig 1

Wu C., Wang Q, & Li Y. (2019). Prediction and evaluation of neoadjuvant chemotherapy using the dual mechanisms of 99mTc-MIBI scintigraphy in patients with osteosarcoma. Journal of Bone Oncology, 17, 100250.

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Lung Perfusion Scans Using 99mTc-MAA

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Lung perfusion scans were acquired using the OPTIMA NM/CT 670 or OPTIMA NM/CT 640 gamma camera (GE Medical System, West Milwaukee, WI, USA) soon after the intravenous injection of 185–370 MBq metastable technetium 99-labelled macroaggregated albumin (^99mTc-MAA) particles.
According to the European Association of Nuclear Medicine (EANM) guidelines [8 (link)], LPS was acquired via the planar technique in the anterior, posterior, right and left posterior/anterior oblique, and latero-lateral projections, using the following acquisition parameters: 128 × 128 matrix and 500–700 K counts per projection.
If necessary, an additional acquisition of LPS was performed using the single photon emission tomography (SPET) or SPET/CT techniques to obtain tomographic images with additional morpho-functional details.
In order to interpret LPS, the two criteria suggested by the Prospective Investigative Study of Acute Pulmonary Embolism Diagnosis (PISAPED) were used: (1) the presence of single or multiple wedge-shaped perfusion defects; and (2) the size of pulmonary perfusion defects (in the segmental or subsegmental region) [12 (link)].

Rubini G., Ferrari C., Mammucci P., Pisani A.R., Mincarone P, & Leo C.G. (2021). Healthcare and Economic Impact of Lung Perfusion Scintigraphy in Patients Affected by Acute Pulmonary Embolism. Healthcare, 9(6), 716.

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Sentinel Lymph Node Imaging Protocol

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The tracer was applied cervically in four quadrants (4mCi), followed by SLN mapping on a dynamic study after application of the radiopharmaceutical and static images at 30 minutes, 60 minutes, and 120 minutes in the anteroposterior position (600 seconds/image, matrix 256 * 256 * 16). The planar images were taken with a Mediso DHV Nucline Spirit gamma camera.SPECT/CT images were taken after 120 to 180 minutes with OPTIMA NM/CT 640 GE Healthcare dual detector/4 slice CT camera: SPECT (60 projections for 15 seconds per projection, projection angle: 6 degrees, detector angle: 180 degrees, matrix 128 * 128) and CT (matrix 512 * 512, rotation time: 1 second, cross-sectional thickness: 2.5 mm, cross-sectional distance 2.5 mm).

Jankulovska A., Stojcevski S., Aluloski I., Tanturovski M., Manevska N., Markova A.D, & Stojanoski S. (2023). Predictors of Bilateral SLN Radiocolloid Detection in Endometrial Carcinoma. World Journal of Nuclear Medicine, 22(4), 261-266.

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Multimodal Imaging of Ankle and Foot Infections

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To perform simultaneous ¹¹¹In-WBC and ^99mTc-SC imaging, ¹¹¹In- WBC was injected intravenously, and ^99mTc-SC was injected on the following day. Thirty minutes post-^99mTc-SC administration, ¹¹¹In- WBC and ^99mTc-SC planar as well as SPECT/CT images of the ankles and feet were obtained concurrently with a pair of medial-energy collimators. The SPECT/CT imaging was acquired by setting up multiple photo peaks in the camera including a 10% window centered on 140 keV, a 10% window centered on 171 keV, and a 15% window centered on 245 keV in the Optima NM/CT 640 (GE Healthcare) camera. Three-dimensional SPECT images were reconstructed using a Xeleris Work station with Volumetrix MI Evolution software (GE Healthcare). A low-dose CT scan, at 120 kV and 20 mAs, was obtained immediately following the SPECT scan. The radiation dose of this low-dose CT scan is about 2.7 mSv.

Mayeux A.M., Nakrour N., Li A.Y., Ballard D.H, & Yang Z. (2019). Simultaneous 111In-WBC and 99mTc-SC SPECT/CT Clearly Delineates Infection Sites. Annals of trauma and acute care, 3(1), 1017.

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Diagnosing Pulmonary Embolism in Pregnant Patients

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CTPA and V/Q scan were used as reference standards. However, perfusion
scintigraphy was considered sufficient for pregnant participants. All CTPAs were
performed on a GE Revolution CT (GE Healthcare, Waukesha, Wisconsin, USA) and
V/Q scans on a Discovery NM-CT 670 or Optima NM-CT 640 (General
Electric, Boston, Massachusetts, USA). Interpreting radiologists and nuclear
medicine physicians were blinded to ultrasound findings. In patients without PE,
the final diagnosis was obtained through medical record audit at the end of the
study period by two independent assessors. Any discrepancies were resolved by
consensus discussion or final decision by the study’s last author.

Falster C., Egholm G., Wiig R., Poulsen M.K., Møller J.E., Posth S., Brabrand M, & Laursen C.B. (2023). Diagnostic Accuracy of a Bespoke Multiorgan Ultrasound Approach in Suspected Pulmonary Embolism. Ultrasound International Open, 8(2), E59-E67.

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DaT SPECT Imaging Phantom Protocol

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Scans were performed on the two-detector hybrid camera (GE Optima NM/CT640) with the following acquisition parameters corresponding to international guidelines for DaT SPECT imaging: rotational radius of 11 cm, photopeak 159 KeV ± 10%, matrix 128 × 128, zoom 1.33, angular step 3°, frame time 40 s. Total detected events were > 1.5 million total counts. The phantom’s low-dose CT scan (tube voltage 120 kV, tube current 20 mA, pitch 1, slice thickness 2.5 mm, pixels 512 × 512) was performed to calculate the attenuation correction (AC) map.

Laskov V., Rothbauer D, & Malikova H. (2024). Robustness of radiomic features in 123I-ioflupane-dopamine transporter single-photon emission computer tomography scan. PLOS ONE, 19(4), e0301978.

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Cardiac SPECT Imaging with CTAC

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We obtained all images over a 180° angle orbit from right anterior oblique, 45° angle to left posterior oblique, 45° angle using a dual-head γ-camera (General Electric Optima NM/CT 640, GE Healthcare, Wauwatosa, WI, USA) equipped with ultra-high resolution collimator, 64x64 matrix, an elliptic orbit with step and shoot acquisition at 3° intervals over 180° angle, 60 projections and 9-13 s per projection using a 20% energy window centered on the 140 keV photopeak of Tc-99m. The patients lay in supine position on the surface with their arms raised straight above the head. Image sets obtained by SPECT analysis were reconstructed on a dedicated workstation (Xeleris, GE Healthcare, Haifa, Israel) using WBR and Evolution for Cardiac recommended manufacturer relative risk and noise reduction parameters, with and without CT based AC (12 iterations and 10 subsets). At the end of each acquisition, a single low-dose CT scan (100 keV; 1.0 mA; 0.2-0.3 mS) of the chest was performed to obtain attenuation maps automatically applied by the processing software in order to correct the emission data. The MPI dataset was carefully re-matched with the CT attenuation map to produce the attenuation corrected images.

Efe S.Ç., Özdemir Candan Ö., Gündoğan C., Öz A., Yüksel Y., Ayca B, & Çermik T.F. (2020). Value of C-reactive Protein/Albumin Ratio for Predicting Ischemia in Myocardial Perfusion Scintigraphy. Molecular Imaging and Radionuclide Therapy, 29(3), 112-117.

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