Cocaine-HCl was obtained from the National Institute on Drug Abuse. Dihydro-β-erythroidine hydrobromide (DHBE), nomifensine, quinpirole-HCl, and SCH23390 were purchased from Tocris Bioscience. Dopamine-HCl was purchased from Sigma-Aldrich. All drugs were dissolved in ACSF. All other drugs and reagents, unless otherwise indicated, were obtained from Sigma-Aldrich.
Quinpirole hcl
Manufactured by Bio-Techne
Sourced in United Kingdom
Quinpirole HCl is a laboratory reagent used in research applications. It is a selective dopamine D2/D3 receptor agonist. The product is provided as a crystalline powder.
Automatically generated - may contain errors
Lab products found in correlation
Nomifensine, by Bio-Techne (1 mentions)
Dopamine hcl, by Merck Group (1 mentions)
Sch23390, by Bio-Techne (1 mentions)
Benserazide, by Merck Group (1 mentions)
Pargyline, by Merck Group (1 mentions)
N methyl d aspartate nmda, by Merck Group (1 mentions)
Forskolin, by Merck Group (1 mentions)
Sch 23390 hcl, by Bio-Techne (1 mentions)
Desipramine hcl, by Merck Group (1 mentions)
L dopa methyl ester hcl, by Merck Group (1 mentions)
U0126, by Bio-Techne (1 mentions)
4 protocols using quinpirole hcl
1
Cocaine and Dopamine Receptor Assays
2
Alcohol and Drug Preparation Protocol
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Ethanol (95% ethyl alcohol; The Warner‐Graham Company; Cockeysville, MD) was diluted each morning prior to mixing with Tang. (‐)‐Cocaine HCl was obtained from the National Institute on Drug Abuse (Bethesda, MD), and quinpirole HCl was purchased form Tocris Bioscience (Bristol, UK). These were dissolved in sterile 0.9% saline. Doses are expressed based on the salt form.
3
Cocaine and Quinpirole Preparation
4
Preparation and Administration of Pharmacological Agents for In Vitro and In Vivo Experiments
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For all in vitro experiments, SKF 81297 HBr (Toronto Research Chemicals), N-methyl-d -aspartate (NMDA, Sigma-Aldrich), forskolin (Sigma-Aldrich), SCH 23390 HCl (Tocris) and U0126 (Tocris), were initially dissolved in DMSO to prepare stock solutions and then diluted to the desired concentration in artificial cerebrospinal fluid. For in vivo experiments, SKF 81297 HBr, quinpirole HCl and SCH 23390 HCl (Tocris) were dissolved in physiological saline and injected in a volume of 1 ml/kg. For 6-OHDA lesion experiments, desipramine HCl (Sigma-Aldrich), and pargyline (Sigma-Aldrich) were dissolved in physiological saline and injected at a volume of 1 ml/kg. 6-OHDA HBr (MilliporeSigma) was prepared at 7 µg/µl dissolved in 0.02% ascorbic acid and 0.9% NaCl, and stored at – 80 °C for up to 1 week prior to use. For dyskinesia experiments, l -DOPA methyl ester HCL and benserazide (Sigma) were dissolved in 0.9% saline with 0.1% ascorbate and injected s.c. at 1 ml/kg.
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