Sta edoxaban control

Manufactured by Stago

Sourced in United States, France

The STA®Edoxaban Control is a laboratory control material used to monitor the performance of coagulation tests for edoxaban, a direct oral anticoagulant. It provides a consistent and standardized sample to evaluate the accuracy and precision of test results.

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Lab products found in correlation

Sta edoxaban calibrator, by Stago (2 mentions) Hemosil liquid heparin, by Werfen (1 mentions) Sta r evolution, by Stago (1 mentions) Sta liquid anti xa, by Stago (1 mentions)

2 protocols using sta edoxaban control

Comparative Analysis of Edoxaban Anti-Xa Assays

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Anti-Xa activity was measured prospectively on Days 1, 4, 8 and 15. Blood was drawn one hour after drug intake on Days 1, 4 and 8 and 12 h after the last drug intake on Day 15.
The anti-Xa activity of edoxaban was measured using (i) Testzym^ⓇHeparin S (Sekisui Medical Co., Ltd., Tokyo, Japan) on the Coagrex^Ⓡ 800 System (Sekisui; assay A) [15 (link), 19 (link)]; (ii) STA®-Liquid Anti-Xa (Stago, Asnières-sur-Sreine, France) on STA^Ⓡ-R Evolution® coagulometer (Stago; assay B) with a dedicated test set-up [21 (link)]; and (iii) HemosIL® Liquid Heparin (Instrumentation Laboratory; Bedford, MA, USA) on ACL-TOP® (Instrumentation Laboratory; assay C) [21 (link), 22 (link)].
Assay A was calibrated using a fondaparinux-specific standard and results were expressed in fondaparinux mg/L. Assay B was calibrated using a edoxaban-specific calibrator set (STA®Edoxaban calibrator) and verified using an edoxaban-specific control set (STA®Edoxaban Control), both developed by Stago. Assay C was calibrated using the HemosIL Liquid Heparin Calibrator (Instrumentation Laboratory). Results for assay C were expressed in heparin international units (IU)/mL. Assay A contains additional antithrombin (AT) in the assay system, while assays B and C do not.

Ikejiri M., Wada H., Tone S., Wakabayashi H., Hasegawa M., Matsumoto T., Fujimoto N., Yamada N., Ito M., Nakatani K, & Sudo A. (2017). Comparison of three different anti-Xa assays in major orthopedic surgery patients treated with direct oral anticoagulant. Thrombosis Journal, 15, 27.

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Quantifying Direct Xa Inhibitor Levels

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The concentration of direct anti-Xa inhibitors in the patient's plasma will be inferred from the one-stage chromogenic assay STA-Liquid Anti-Xa assay (Stago Deutschland GmbH, Düssedlorf, Germany), which is used together with a drug-specific calibrator and control (STA-Apixaban Calibrator and STA-Apixaban Control, STA-Rivaroxaban Calibrator and STA-Rivaroxaban Control, STA-Edoxaban Calibrator and STA-Edoxaban Control, Stago, Asnières-sur-Seine, France). Chromogenic tests measure the capacity of residual factor Xa of the patient's plasma to hydrolyze a chromogenic substrate by measuring the change in optical density per minute, which is inversely correlated with the concentration of direct Xa inhibitor in the patient's plasma. After plotting a drug-specific calibration curve with anti-Xa activity (IU/mL) on the
y-axis and the concentration of the respective direct Xa inhibitor (ng/mL) on the
x-axis, the concentration of the respective direct Xa inhibitor in the patient's plasma can be inferred from the calibration curve. The lower detection limit is 25 ng/mL for rivaroxaban, 20 ng/mL for apixaban, and 10 ng/mL for edoxaban.

Sedghi A., Heubner L., Klimova A., Tiebel O., Pietsch J., Mirus M., Barlinn K., Minx T., Beyer-Westendorf J., Puetz V., Spieth P, & Siepmann T. (2022). Point-of-Care Assessment of Direct Oral Anticoagulation in Acute Ischemic Stroke: Protocol for a Prospective Observational Diagnostic Accuracy Study. Thrombosis and Haemostasis, 122(11), 1954-1962.

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