APP/PS1 (JAX, Stock # 034848) and 5×FAD (JAX, Stock # 034848) transgenic mice were purchased from The Jackson Laboratory and generously provided by Dr. Guobing Chen (Jinan University, China). In this study, we crossed the APP/PS1 or 5×FAD with C57BL/6 mice (GemPharmatech, China) to obtain daughter mice for further study. All mice were maintained under standard laboratory conditions with free access to food and water unless otherwise indicated. All experiments were conducted in accordance with the regulations for the Administration of Affairs Concerning Experimental Animals (China) and approved by the China Pharmaceutical University Animal Ethics Committee. Mice were genotyped by One Step Mouse Genotyping Kit (Vazyme, Cat# PD104-01), according to manufacturer's instructions.
App ps1 jax
Manufactured by Jackson ImmunoResearch
Sourced in China
The APP/PS1 (JAX) is a genetically modified mouse model developed by Jackson ImmunoResearch. It is designed to express mutant forms of the amyloid precursor protein (APP) and presenilin 1 (PS1) genes, which are associated with the development of Alzheimer's disease. This model can be used for research purposes to study the underlying mechanisms and pathological features of Alzheimer's disease.
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Transgenic Mouse Models for AD
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Transgenic Mouse Models for AD Study
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APP/PS1 (JAX, Stock # 034848) and 5×FAD (JAX, Stock # 034848) transgenic mice were purchased from The Jackson Laboratory and generously provided by Dr. Guobing Chen (Jinan University, China). In this study, we crossed the APP/PS1 or 5×FAD with C57BL/6 mice (GemPharmatech, China) to obtain daughter mice for further study. All mice were maintained under standard laboratory conditions with free access to food and water unless otherwise indicated. All experiments were conducted in accordance with the regulations for the Administration of Affairs Concerning Experimental Animals (China) and approved by the China Pharmaceutical University Animal Ethics Committee. Mice were genotyped by One Step Mouse Genotyping Kit (Vazyme, Cat# PD104-01), according to manufacturer's instructions.
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