Promethazine

Montelukast, pranlukast and zafirlukast as leukotriene receptor antagonists were purchased from Cayman Chemical (Ann Arbor, MI, USA). Suplatast tosilate as a Th2 cytokine inhibitor, sodium cromoglicate, tranilast, amlexanox and pemirolast as mediator release inhibitors, ozagrel as a thromboxane A2 synthesis inhibitor, seratrodast as a thromboxane A 2 receptor antagonist, diphenhydramine as an ethanolamine H1 blocker, chlorpheniramine as a propylamine H1 blocker, cyproheptadine as a piperidine H1 blocker, promethazine as a phenothiazine H1 blocker, and ketotifen, fexofenadine, epinastine, cetirizine, levocetirizine, emedastine, loratadine, azelastine, mequitazine and ebastine as second-generation H1 receptor antagonists were purchased from Tokyo Chemical Industry (Tokyo, Japan).

Twenty phototoxic chemicals and 10 non-phototoxic chemicals were evaluated, including 6 drugs, 8 antimicrobials, 6 fragrances, 6 UV absorbers, and 4 other chemicals. Amiodarone HCl (1), anthracene (7), chlorpromazine HCl (9), 5-methoxypsoralen (15), 8-methox-ypsoralen (16), 6-methylcoumarin (17), ofloxacin (18) , hexachlorophene (21), ethylhexyl dimethyl p-aminobenzoate (23), chlorhexidine dihydrochloride (24), sodium lauryl sulfate (27), p-aminobenzoic acid (28), sulisobenzone (29), and lactic acid (30) were purchased from Sigma-Aldrich Japan (Tokyo, Japan). Rose bengal (2), bithionol (4), 3,3'4,5 tetrachlorosalicylanilide (5), fenofibrate (6), benzophenone (11), ketoprofen (13), methyl n-methylantranilate ( 14), and norfloxacin (19) were purchased from Wako Pure Chemical Industries (Osaka, Japan). 3,4',5-Tribromosalicylanilide (3), musk ambrette (8), promethazine (10), musk xylene (12), protoporphyrin IX, disodium (20), 2-octyl salicylate ( 22), 2-octyl methacrylate (25), and penicillin G (26) were purchased from Tokyo Chemical Industry (Tokyo, Japan).