Inositol hexaphosphate

Manufactured by Merck Group

Sourced in United States

Inositol hexaphosphate is a chemical compound that consists of the inositol molecule with six phosphate groups attached. It is a naturally occurring substance found in various plant and animal tissues. The core function of inositol hexaphosphate is to serve as a storage and signaling molecule in biological systems.

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Lab products found in correlation

P akt, by Santa Cruz Biotechnology (1 mentions) P stat3, by Santa Cruz Biotechnology (1 mentions) N ethyl n nitrosourea, by Merck Group (1 mentions) Caspase 3, by Santa Cruz Biotechnology (1 mentions) Stat3, by Santa Cruz Biotechnology (1 mentions) β actin, by Cell Signaling Technology (1 mentions) Cyclin d1, by Santa Cruz Biotechnology (1 mentions) Caspase 9, by Santa Cruz Biotechnology (1 mentions) Bezafibrate, by Merck Group (1 mentions)

Close spelling variants of this product

Inositol

3 protocols using inositol hexaphosphate

Inositol Hexaphosphate Cell Culture Protocol

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Inositol hexaphosphate was purchased from Sigma-Aldrich (St. Louis, MO, USA). It
was directly dissolved in RPMI 1640 medium containing 10% FBS, and the pH adjusted at 7.0 using
1 M NaOH and 1 M HCl to prepare 40 mM IP6 fresh stock solution. The stock
solution was added into the culture medium in which cells were being cultured, to obtain the
final concentration of IP6.

Kato A., Hirakawa Y, & Hiraoka W. (2019). Inositol hexaphosphate-induced cellular response in myeloid leukemia cells is mediated by nicotinamide adenine dinucleotide phosphate oxidase activation. Fujita Medical Journal, 5(4), 98-103.

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Anticarcinogenic Potential Evaluation

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N-ethyl-N-nitrosourea and inositol hexaphosphate were procured from Sigma Co. (USA). [methyl-³H] thymidine (specific activity 17.20 Ci/mmol) was provided by BRIT, Mumbai, India. caspase-3 or -9 enzyme activity assay kit was procured from R&D system, USA. The Super Signal West Femto Max Substrate was procured from Thermo Fischer Scientific, USA. Primary antibodies for PCNA, cyclin D1, NF-κB (p50), IL-6, STAT3, pSTAT3, pAkt, PARP, caspase-3 and caspase-9 were purchased from Santa Cruz Biotechnologies, USA and antibodies for COX-2, Akt and β-actin were from Cell Signalling Technology, USA. The rest of the chemicals were purchased from local commercial sources and were of analytical grade.

Sahay S., Tiwari P, & Gupta K.P. (2015). Onset of the lymphocytic infiltration and hyperplasia preceding the proliferation in F1 mouse lungs from the N-ethyl-N-nitrosourea exposed mothers: Prevention during the lactation period by inositol hexaphosphate. Toxicology Reports, 2, 590-599.

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Characterization of Biomolecular Interactions

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Chemicals such as sodium chloride (NaCl), 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), inositol hexaphosphate (IHP), 2,3-diphosphoglycerate (DPG) and bezafibrate (BZF), the highest purity available, were purchased from Sigma-Aldrich (St. Louis). Catalogue numbers are 68388 (IHP), D5764 (DPG), B7273 (BZF). All samples were prepared in 100 mM HEPES, pH 7.4 with double distilled water.

Schay G., Fidy J, & Herenyi L. (2022). Slow dynamics measured by phosphorescence lifetime reveals global conformational changes in human adult hemoglobin induced by allosteric effectors. PLOS ONE, 17(12), e0278417.

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