Ingenuity tof pet 64 slice ct scanner

Manufactured by Philips

The Ingenuity TOF-PET/64-slice CT scanner is a diagnostic imaging system that combines Positron Emission Tomography (PET) and Computed Tomography (CT) technologies. It is designed to acquire high-quality images of the human body for medical purposes.

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Lab products found in correlation

Body dynamic xml, by Philips (2 mentions) Fusion viewer, by Philips (1 mentions)

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Ingenuity CT (27 citations) CT scanners (6 citations) PET/CT scanner (4 citations) Ingenuity CT scanner (3 citations) Ingenuity PET/CT scanner (2 citations) Ingenuity CT 64 (2 citations)

3 protocols using ingenuity tof pet 64 slice ct scanner

Comparative PSMA and FDG-PET/CT Imaging Protocol

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⁶⁸Ga-HBEDD-CC PSMA-11 was produced on-site in compliance with good laboratory practices using a Trasis automated radiopharmacy cassette. ¹⁸F-FDG was produced off-site commercially. Radiopharmacy quality control testing used a high-pressure liquid chromatography method. Patients were injected with a 2.0 MBq/kg dose of PSMA and a 3.5 MBq/kg dose of ¹⁸F-FDG, with identical imaging parameters (dose, time after injection, and imaging protocols) for each patient. All PET/CT imaging was undertaken using a Phillips Ingenuity TOF-PET/64-slice CT scanner. An unenhanced low-dose CT scan was performed 60 min after tracer injection. Immediately after CT, a whole-body PET scan was acquired for 2 min per bed position.
PET/CT scans were analyzed semiquantitatively using MIM software and a standardized semiautomated workflow to delineate regions of interest with a minimum SUV_max cutoff of 3 for PSMA and blood pool intensity, plus 1.5 SDs for ¹⁸F-FDG (17 ). Quantitation derived total metabolic tumor volume, SUV_max, SUV_mean, and total lesional activity for both ¹⁸F-FDG and PSMA (MIM Software).

Pathmanandavel S., Crumbaker M., Yam A.O., Nguyen A., Rofe C., Hovey E., Gedye C., Kwan E.M., Hauser C., Azad A.A., Eu P., Martin A.J., Joshua A.M, & Emmett L. (2022). 177Lu-PSMA-617 and Idronoxil in Men with End-Stage Metastatic Castration-Resistant Prostate Cancer (LuPIN): Patient Outcomes and Predictors of Treatment Response in a Phase I/II Trial. Journal of Nuclear Medicine, 63(4), 560-566.

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Standardized PSMA PET/CT Imaging Protocol

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PSMA was produced on-site compliant to the Good Laboratory Practices procedure using a TRASIS automated radiopharmacy cassette. Radiopharmacy quality control was undertaken using a high-pressure liquid chromatography method. Patients were injected with 68 Ga-PSMA (2.0 MBq/kg) (H-BED CC). All PET/CT imaging was undertaken using a Phillips Ingenuity TOF-PET/64-slice CT scanner. For the PSMA PET/CT, a non-contrast-enhanced CT scan was obtained 45 min after tracer injection using the following CT parameters: slice thickness of 2 mm, with 2-mm slices, soft-tissue reconstruction kernel, 120 keV and 50 mAs, pitch of 0Á828, 600 mm field of view, and a 512 matrix.
Immediately after CT scanning, a whole-body PET scan was acquired for 2 min per bed position. The emission data were corrected for randoms, scatter, and decay using the Phillips Body-dynamic.xml and Body.xml reconstruction protocol. All images were viewed and reported using the Phillips Fusion Viewer.

Emmett L., van Leeuwen P.J., Nandurkar R., Scheltema M.J., Cusick T., Hruby G., Kneebone A., Eade T., Fogarty G., Jagavkar R., Nguyen Q., Ho B., Joshua A.M, & Stricker P. (2017). Treatment Outcomes from ⁶⁸Ga-PSMA PET/CT-Informed Salvage Radiation Treatment in Men with Rising PSA After Radical Prostatectomy: Prognostic Value of a Negative PSMA PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 58(12).

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Longitudinal 68Ga-PSMA PET Imaging

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Serial 68 Ga-PSMA PET scans were obtained at baseline and on days 9, 18, and 28 after commencing AB. 68 Ga-HBEDD-CC PSMA-11 ( 68 Ga-PSMA) was produced on-site compliant with good laboratory practice procedure using a TRASIS automated radiopharmacy cassette. Radiopharmacy quality control was undertaken using a highpressure liquid chromatography method. Patients were injected with 2.0 MBq of 68 GaPSMA per kilogram, with imaging parameters (dose, time after injection, and imaging protocols) repeated identically at each time point for each patient enrolled. All PET CT imaging was undertaken using a Phillips Ingenuity TOF-PET/64 slice CT scanner. A non-contrast-enhanced CT scan was acquired 60 min after tracer injection using the following CT parameters: 2 mm slice thickness soft-tissue reconstruction kernel, 120 keV and 50 mAs, pitch of 0.828, 600 mm field of view, and a 512 matrix. Immediately after CT scanning, a whole-body PET scan was acquired for 2 min per bed position. The emission data were corrected for randoms, scatter, and decay using the Phillips Body-dynamic.xml and Body.xml reconstruction protocol.

Emmett L., Yin C., Crumbaker M., Hruby G., Kneebone A., Epstein R., Nguyen Q., Hickey A., Ihsheish N., O'Neill G., Horvath L., Chalasani V., Stricker P, & Joshua A.M. (2019). Rapid Modulation of PSMA Expression by Androgen Deprivation: Serial ⁶⁸Ga-PSMA-11 PET in Men with Hormone-Sensitive and Castrate-Resistant Prostate Cancer Commencing Androgen Blockade. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 60(7).

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