Log In Sign up
The largest database of trusted experimental protocols

Pitavastatin

Manufactured by Bio-Techne
Visit Supplier
Sourced in United Kingdom, United States

Pitavastatin is a laboratory product offered by Bio-Techne. It is a synthetic compound used for research purposes. Pitavastatin is a member of the statin class of drugs, which are known for their ability to lower cholesterol levels. The core function of Pitavastatin is to inhibit the enzyme HMG-CoA reductase, a key step in the cholesterol synthesis pathway.

Automatically generated - may contain errors

Lab products found in correlation

L glutamine, by Thermo Fisher Scientific (1 mentions) Epigallocatechin gallate (egcg), by Selleck Chemicals (1 mentions) Dimethyl α ketoglutarate, by Merck Group (1 mentions) Bcl w, by Cell Signaling Technology (1 mentions) Atorvastatin, by Bio-Techne (1 mentions) Abt 199, by Selleck Chemicals (1 mentions) Rapamycin, by Selleck Chemicals (1 mentions) Caspase 3, by Cell Signaling Technology (1 mentions) Bcl2 associated x (bax), by Santa Cruz Biotechnology (1 mentions) Caspase 9, by Cell Signaling Technology (1 mentions) Bcl xl, by Cell Signaling Technology (1 mentions) Oxaloacetate, by Merck Group (1 mentions) Simvastatin, by Selleck Chemicals (1 mentions) Cb 839, by Selleck Chemicals (1 mentions) Mcl 1, by Santa Cruz Biotechnology (1 mentions) Slc1a5, by Abcam (1 mentions) Glud1, by Abcam (1 mentions) Sb204990, by Bio-Techne (1 mentions) Bafilomycin a1, by Bio-Techne (1 mentions) Gapdh, by Santa Cruz Biotechnology (1 mentions)

3 protocols using pitavastatin

1

Apoptosis pathway inhibitors protocol

Check if the same lab product or an alternative is used in the 5 most similar protocols
ABT-263, A-1331852 and A-1210477 were from AbbVie (North Chicago, IL, USA),
ABT-199, epigallocatechin gallate (EGCG), CB-839, simvastatin, rapamycin and
torin-1 from Selleck Chemicals (Houston, TX, USA),
gamma-L-glutamyl-p-nitroanilide (GPNA) from Insight
Biotechnology (Wembley, Middlesex, UK), azaserine from Cambridge Bioscience
(Cambridge, UK), aminooxyacetate (AOA), sodium palmitate, dimethyl
α-ketoglutarate, oxaloacetate and citrate from Sigma-Aldrich
(Gillingham, UK), L-glutamine from Life Technologies (Paisley, UK) and
GSK2194069, SB204990, atorvastatin, pitavastatin and bafilomycin A1 from Tocris
(Abingdon, UK). Antibodies against PARP, BCL-2, MCL-1, BAX, BAK and GAPDH were
from Santa Cruz Biotechnology (Santa Cruz, CA, USA), caspase-3, caspase-9,
BCL-XL, BCL-w, BIM, PUMA, BAD, IDH2, ACL, ACO2, ATG5 and ATG7
from Cell Signaling Technology (MA, USA), BID from Prof. J. Borst (The
Netherlands Cancer Institute, Amsterdam, the Netherlands), NOXA from Millipore
(Watford, UK) and SLC1A5, GLS, GFAT, GLUD1, IDH3, FASN and HMGR from Abcam
(Cambridge, UK).
Al-Zebeeby A., Vogler M., Milani M., Richards C., Alotibi A., Greaves G., Dyer M.J., Cohen G.M, & Varadarajan S. (2019). Targeting intermediary metabolism enhances the efficacy of BH3 mimetic therapy in hematologic malignancies. Haematologica, 104(5), 1016-1025.
+ Open protocol
+ Expand
2

Pitavastatin Treatment Protocol

Check if the same lab product or an alternative is used in the 5 most similar protocols
All chemicals and cell culture reagents were obtained from commercial sources. Pitavastatin was obtained from Tocris and dissolved in dimethyl sulfoxide (DMSO), and the latter was used as vehicle control for cellular studies where noted.
Piktel D., Moore J.C., Nesbit S., Sprowls S.A., Craig M.D., Rellick S.L., Nair R.R., Meadows E., Hollander J.M., Geldenhuys W.J., Martin K.H, & Gibson L.F. (2023). Chemotherapeutic Activity of Pitavastatin in Vincristine Resistant B-Cell Acute Lymphoblastic Leukemia. Cancers, 15(3), 707.
+ Open protocol
+ Expand
3

Evaluating Combination Treatments on REH Cell Viability

Check if the same lab product or an alternative is used in the 5 most similar protocols
REH cells were treated for 2 days with an ATP citrate lyase inhibitor, BMS-303141 (10 μM) (Tocris, Minneapolis, MN, USA), an HMG-CoA reductase inhibitor, pitavastatin (1 μM) (Tocris, Minneapolis, MN, USA), a chemotherapy agent, cytarabine (Ara-C, 0.1 μM) (Sigma Aldrich, St. Louis, MO, USA) or the combinations, as indicated. Following treatment, the media cells (M), suspended cells (S), and phase dim cells (PD) were recovered, and the viability and total cell count were analyzed using the trypan blue exclusion method.
Piktel D., Nair R.R., Rellick S.L., Geldenhuys W.J., Martin K.H., Craig M.D, & Gibson L.F. (2022). Pitavastatin Is Anti-Leukemic in a Bone Marrow Microenvironment Model of B-Lineage Acute Lymphoblastic Leukemia. Cancers, 14(11), 2681.
+ Open protocol
+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required

Sign up now

Revolutionizing how scientists
search and build protocols!