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616 protocols using magnetom tim trio

1

High-resolution T1w MRI Brain Imaging

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Participants from the SLIM database had a high-resolution T1w MP-RAGE sequence (identical with the sequence applied in the first centre) acquired on a 3T MRI scanner (Magnetom Tim Trio, Siemens, Germany). The T1w sequence parameters were: TR = 1900 ms, TE = 2.52 ms, TI = 900 ms, FA = 9°, matrix size 256 × 256, slice thickness = 1 mm, and voxel size = 1 × 1 × 1 mm3.
From the OASIS-3 database high-resolution T1w MP-RAGE sequences acquired on a 3 T MRI scanner (Magnetom Tim Trio, Siemens, Germany) were extracted. The T1w sequence parameters: TR = 400 ms, TE = 3.16 ms, TI = 1000 ms, FA = 8°, matrix size 256 × 256, slice thickness = 1 mm, and voxel size = 1 × 1 × 1 mm3.
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2

Real-Time fMRI-Based Emotion Regulation Protocol

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All functional images were acquired using a 3.0 T MR Siemens scanner, with a 12 channels head coil (Siemens Magnetom Trio Tim, Siemens, Erlangen, Germany. During real-time fMRI-based emotion regulation, standard echo planar imaging (EPI) images consisting of sixteen axially oriented slices (voxel size = 3 × 3 × 5 mm3, slice gap = 1 mm) were acquired (repetition time TR = 1500 ms, matrix size = 64 × 64, FoV = 192 × 192 mm, TE = 30 ms). Considering that the primary respiratory-related component of the fMRI signal usually fluctuates at about 0.3 Hz, a TR equal to 1.5 s prevents aliasing of the first respiratory harmonics with a spectral signature of the typical BOLD effect [48 (link)]. Additionally, a gradient echo field map (TR 488 ms, TE 1 = 4.49 ms, TE 2 = 6.95 ms) and a T1-weighted MPRAGE structural scan (matrix size = 256 × 256, 160 partitions, 1 mm3 isotropic voxels, TR = 2300 ms, TE = 3.93 ms, TI = 1100 ms, α = 8°) were acquired from each participant to reduce geometric distortion due to magnetic field inhomogeneities [49 (link)]. In order to minimize head movements, two foam cushions were positioned around the participant’s head.
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3

Functional Neuroimaging of Task Processing

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Participants lay supine on the fMRI scanner bed, and viewed the task back-projected onto a screen through a mirror attached onto the head coil. Foam pads were used to minimize head motion. Stimulus presentation and timing of all stimuli and response events were achieved by using E-prime 2.0 (Psychology Software Tools, Inc. Pittsburgh, PA, USA) on a windows PC. Participants’ responses were collected online using an MRI-compatible button box. The fMRI images were acquired with a Siemens 3T scanner (Siemens Magnetom Trio TIM, Erlangen, Germany) at the Brain Imaging Center of Southwest University. Each functional run involved the acquisition of 197 EPI volumes (slices = 32, TR/TE = 2000 ms/30 ms, flip angle = 90°, FOV = 220 × 220 mm2, matrix size = 64 × 64, slice thickness = 3 mm, and slice gap = 1 mm). After the participants completed 8 functional runs, three-dimensional high-resolution T1 anatomical images were recorded with a total of 176 slices at a thickness of 1 mm and in-plane resolution of 0.98 × 0.98 mm (TR/TE = 1900 ms/2.52 ms, flip angle = 90°, and FOV = 256 × 256 mm2).
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4

Resting-State fMRI Acquisition Protocol

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Images were acquired using a 3.0-Tesla scanner (Siemens Magnetom Trio Tim, Siemens Medical Solutions, Erlangen, Germany) utilizing 32 channel head coil in Tianjin First Central Hospital, Tianjin, China. Before scanning, the patient was asked to lay in a supine position in the MRI table with head firmly fixed by straps and foam pads to minimize head movement.
For resting-state (RS) scanning, participants were asked to close the eyes and remain motionless and not to think of anything, in particular nor fall asleep. The RS functional data were acquired using an echo-planar imaging sequence with the following parameters: TR = 2000 ms, TE = 30 ms, flip angle = 90°, thickness/gap = 5.0/0.0 mm, field of view = 24 cm × 24 cm, matrix = 64 × 64, 300 volumes. A total of 300 slices of resting fMRI were acquired.
Structural images T1-weighted images were acquired using a magnetization-prepared rapid gradient-echo sequence with the following parameters: TR = 1900 ms, TE = 2.52 ms, TI = 900 ms, thickness = 1.0 mm, flip angle = 9°, matrix = 256 × 256, voxel size = 1 × 1×1 mm3.
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5

Magnetic Properties and MRI Relaxation of ENO1-Dex-g-PCL/SPIO Nanoparticles

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Magnetic properties of ENO1‐Dex‐g‐PCL/SPIO nanoparticles were detected by superconducting quantum interference magnetometer (Quantum Design Inc) at room temperature after lyophilization. Next, the efficiency of T2 relaxation for nanoparticles was examined by 1.5T MRI (Siemens Magnetom Trio Tim, Siemens AG) as previously reported.16We prepared SPIO and ENO1‐SPIO granule solutions with iron concentrations of 30, 15, 7.5, 3.75, 1.875 and 0.9375 ug/mL and then added 1 mL 2% agarose to prepare a final concentration of 1% agarose. Next, 1% agarose was used as a blank control to detect the T2 value and T2* value of different concentrations of iron particle solution. The corresponding relaxation rates R2 and R2* were calculated as 1/T2 and 1/T2*, respectively.
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6

fMRI-Based Emotion Regulation Protocol

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All functional images were acquired using a 3.0 T MR Siemens scanner, with a 12 channels head coil (Siemens Magnetom Trio Tim, Siemens, Erlangen, Germany) . During real-time fMRI-based emotion regulation, standard echo planar imaging (EPI) images consisting of sixteen axially oriented slices (voxel size=3×3×5 mm 3 , slice gap=1 mm) were acquired (repetition time TR=1500 ms, matrix size=64×64, FoV= 192x192mm, TE=30 ms). Considering that the primary respiratory-related component of the fMRI signal usually uctuates at about 0.3 Hz, a TR equal to 1.5s prevents aliasing of the rst respiratory harmonics with spectral signature of the typical BOLD effect (Caballero-Gaudes & Reynolds, 2017) . Additionally, a gradient echo eld map (TR 488 ms, TE 1 = 4.49 ms, TE 2 = 6.95 ms) and a T1-weighted MPRAGE structural scan (matrix size = 256 x 256, 160 partitions, 1 mm 3 isotropic voxels, TR = 2300 ms, TE = 3.93 ms, TI = 1100 ms, α = 8°) were acquired from each participant to reduce geometric distortion due to magnetic eld inhomogeneities (Togo, et al., 2017) . In order to minimize head movements two foam cushions were positioned around participant's head.
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7

fMRI-Based Emotion Regulation Protocol

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All functional images were acquired using a 3.0 T MR Siemens scanner, with a 12 channels head coil (Siemens Magnetom Trio Tim, Siemens, Erlangen, Germany) . During real-time fMRI-based emotion regulation, standard echo planar imaging (EPI) images consisting of sixteen axially oriented slices (voxel size=3×3×5 mm 3 , slice gap=1 mm) were acquired (repetition time TR=1500 ms, matrix size=64×64, FoV= 192x192mm, TE=30 ms). Considering that the primary respiratory-related component of the fMRI signal usually uctuates at about 0.3 Hz, a TR equal to 1.5s prevents aliasing of the rst respiratory harmonics with spectral signature of the typical BOLD effect (Caballero-Gaudes & Reynolds, 2017) . Additionally, a gradient echo eld map (TR 488 ms, TE 1 = 4.49 ms, TE 2 = 6.95 ms) and a T1-weighted MPRAGE structural scan (matrix size = 256 x 256, 160 partitions, 1 mm 3 isotropic voxels, TR = 2300 ms, TE = 3.93 ms, TI = 1100 ms, α = 8°) were acquired from each participant to reduce geometric distortion due to magnetic eld inhomogeneities (Togo, et al., 2017) . In order to minimize head movements two foam cushions were positioned around participant's head.
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8

Magnetic Resonance Imaging Brain Scan Protocol

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Participants were positioned head first and supine in the magnetic bore. Images were acquired with a Siemens 3T scanner (Siemens Magnetom Trio TIM, Erlangen, Germany), using a standard eight-channel radio-frequency head coil. Participants were instructed not to move their heads to minimize motion artifacts. An ascending scanning sequence was used. An echo-planar imaging (EPI) sequence was used for data collection, and 367 T2 ‫ء‬ -weighted images were recorded per run (TR ϭ 1,500 ms, TE ϭ 29 ms, flip angle ϭ 90°, FoV ϭ 192 ϫ 192 mm 2 , matrix size ϭ 64 ϫ 64, 25 ascending 5 mm-thick slices, in-plane resolution ϭ 3 ϫ 3 mm 2 , slice skip ϭ 0.5 mm). A structural scan was acquired at the end of the test session (T1-weighted 3D MP-RAGE sequence, 176 slices, TR ϭ 1,900 ms, TE ϭ 2.52 ms, flip angle ϭ 9°, FoV ϭ 250 ϫ 250 mm 2 , voxel size ϭ 1 mmfoot_1 ).
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9

Resting-state fMRI Protocol for Brain Imaging

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rsfMRI data were acquired with a Siemens 3 T scanner (Siemens Magnetom Trio TIM, Erlangen, Germany). Each scan contains 232 functional volumes (about 5 min), collected with an Echo-planar imaging (EPI) sequence (TR = 2 s, TE = 30 ms, flip angle = 75°, matrix size = 64 × 64, FoV = 220 × 220 mm2, voxel size = 3.4 × 3.4 × 3 mm3, Slices = 32). Anatomical images were also collected for normalization with a T1-weighted protocol (TR = 1900 ms, TE = 2.52 ms, FA = 9°, matrix = 64 × 64, FoV = 256 × 256 mm2, voxel size = 1 × 1 × 1 mm3). All subjects were instructed to fixate on the center of the screen, not to think about or concentrate on anything in particular and to remain as motionless as possible. Head movements were minimized by using a cushioned head fixation device.
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10

Resting-state fMRI and T1-weighted Structural MRI

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All images were obtained using a 3T Siemens scanner (MAGNETOM Trio Tim, Siemens, Germany) at the West China Hospital MRI Center, Chengdu, China. During the scanning process, foam cushions were used to reduce head movements and scanner noise. Whole-brain resting-state fMRI was performed using an echo-planar imaging (EPI) sequence: 30 interleaved axial slices; slice thickness = 5 mm; matrix = 64 × 64; repetition time = 2 s; echo time = 30 ms; flip angle = 90°; field-of-view (FOV) = 240 mm × 240 mm; and 180 volume; three-dimensional T1-weighted structural MRI was performed using a spin-echo planar image sequence with the following parameters: repetition time/echo time = 1,900 ms/2.26 ms; flip angle = 9°; in-plane matrix resolution = 256 × 256; slices = 176; field of view = 256 mm × 256 mm; and voxel size = 1 mm × 1 mm × 1 mm. The head coil and foam cushions were used during scanning to reduce head movement. During the acquisition of the imaging data, the participants were instructed to remain awake, remain motionless, keep their eyes closed, and try not to think about anything in particular.
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