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Dl propranolol hydrochloride

Manufactured by Merck Group
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Dl-propranolol hydrochloride is a chemical compound used in laboratory settings. It functions as a non-selective beta-adrenergic receptor antagonist.

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Lab products found in correlation

Indomethacin, by Merck Group (3 mentions) Isoproterenol hydrochloride, by Merck Group (2 mentions) Desipramine hydrochloride, by Merck Group (1 mentions) Papaverine hydrochloride, by Fujifilm (1 mentions) Atenolol, by Merck Group (1 mentions) Histamine dihydrochloride, by Merck Group (1 mentions) Epinephrine bitartrate salt, by Merck Group (1 mentions) Ethidium bromide, by Merck Group (1 mentions) Ici 118 551 hydrochloride, by Merck Group (1 mentions) Choline chloride, by Merck Group (1 mentions) Ultima gold, by PerkinElmer (1 mentions) Picrotoxin, by Merck Group (1 mentions) Nbqx disodium salt, by Hello Bio (1 mentions) Dl noradrenaline hydrochloride, by Merck Group (1 mentions) Cgp 55845, by Hello Bio (1 mentions) Salbutamol hemisulfate, by Bio-Techne (1 mentions) Salmeterol xinafoate, by Merck Group (1 mentions) Carvedilol, by Merck Group (1 mentions) Ici 118 551, by Bio-Techne (1 mentions) Coelenterazine 400a, by Biotium (1 mentions)

7 protocols using dl propranolol hydrochloride

1

Pharmacological Modulation of Vascular Function

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Atenolol, bethanechol chloride, carbamylcholine chloride (carbachol), desipramine
hydrochloride, (–)-epinephrine (+)-bitartrate salt, ethidium bromide, histamine
dihydrochloride, ICI-118,551 hydrochloride, indomethacin, (–)-isoproterenol hydrochloride,
dl-normetanephrine hydrochloride, dl-propranolol hydrochloride, and
prazosin hydrochloride were obtained from Sigma-Aldrich Co. (St. Louis, MO, USA);
(–)-(R)-norepinephrine hydrogen tartrate monohydrate, serotonin
creatinine sulfate, and papaverine hydrochloride were obtained from Wako Pure Chemical
Industries (Osaka, Japan); and prostaglandin F2α was obtained from Fuji Pharma
Co., Ltd. (Tokyo, Japan). (±)-Bupranolol hydrochloride was kindly donated by Kaken
Pharmaceutical Co., Ltd. (Tokyo, Japan).
Atenolol was dissolved in 0.1 N HCl to produce a stock solution of 10−2 M.
indomethacin was dissolved in 100% ethanol to produce a stock solution of 10−2M. All other drugs were prepared as aqueous solutions and diluted with distilled water.
Drugs were added directly to the organ bath and expressed as the molar concentration (M)
in the bath medium.
Chino D., Sone T., Yamazaki K., Tsuruoka Y., Yamagishi R., Shiina S., Obara K., Yamaki F., Higai K, & Tanaka Y. (2018). Pharmacological identification of β-adrenoceptor subtypes mediating isoprenaline-induced relaxation of guinea pig colonic longitudinal smooth muscle. Journal of Smooth Muscle Research, 54, 13-27.
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2

Preparation and Storage of Biochemical Compounds

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Indomethacin, dl-propranolol hydrochloride, hemicholinium-3 bromide, choline chloride, were purchased from Sigma Chemical (Milan, Italy). Methyl [3H]-choline was obtained from NEN™ Life Science Products, Inc. (Boston, MA), and scintillation cocktail Ultima Gold™ from Perkin Elmer (Waltham, MA). GLY and IND were provided by Novartis Pharma (Basel, CH). Indomethacin was dissolved in absolute ethanol and IND in dimethyl sulfoxide; all other compounds were dissolved in distilled water. Fresh solutions were prepared weekly and stored at 4 °C to be used within 7 days.
Baroffio M., Barisione G, & Brusasco V. (2017). Interactions between glycopyrronium and indacaterol on cholinergic neurotransmission and contractile response in bovine trachealis. Respiratory Research, 18, 145.
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3

Preparation of Neurotransmitter Compounds

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DL-noradrenaline hydrochloride and DL-propranolol hydrochloride were purchased from Sigma-Aldrich, fresh stock solutions (50 mM) were made up in dH2O each day and stored on ice. Picrotoxin (Sigma-Aldrich), CGP-55845 (HelloBio) and NBQX di-sodium salt (HelloBio) stock solutions (5 mM, 1 mM, and 20 μM, respectively) were made up in dH2O and stored at −20 °C.
Bacon T.J., Pickering A.E, & Mellor J.R. (2020). Noradrenaline Release from Locus Coeruleus Terminals in the Hippocampus Enhances Excitation-Spike Coupling in CA1 Pyramidal Neurons Via β-Adrenoceptors. Cerebral Cortex (New York, NY), 30(12), 6135-6151.
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4

Novel Compounds and Standard Opioid Evaluation

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Standard opioids were purchased from Cedarlane (Burlington, Canada) and Sigma-Aldrich (St. Louis, MO, USA). Fifteen novel compounds were provided by Pfizer Inc. (Worldwide Research and Development). (−)-Isoproterenol hydrochloride, (−)-norepinephrine, DL-propranolol hydrochloride, ( ± ) metoprolol ( + )-tartrate salt, carvedilol, and salmeterol xinafoate were purchased from Sigma-Aldrich (St Louis, MO). ICI 118,551 and salbutamol hemisulfate were purchased from Tocris Bioscience (Ellisville, MO). Coelenterazine 400a was purchased from Biotium.
Benredjem B., Gallion J., Pelletier D., Dallaire P., Charbonneau J., Cawkill D., Nagi K., Gosink M., Lukasheva V., Jenkinson S., Ren Y., Somps C., Murat B., Van Der Westhuizen E., Le Gouill C., Lichtarge O., Schmidt A., Bouvier M, & Pineyro G. (2019). Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response. Nature Communications, 10, 4075.
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5

Preparation and Use of PAF in Research

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The following drugs were used in this study: PAF C-16 and apafant (Cayman Chemical, Ann Arbor, MI, USA); TTX, suramin sodium and anti-foam (FUJIFILM Wako Pure Chemical Co., Osaka, Japan.); phentolamine mesylate (Novartis Pharma KK, Tokyo, Japan); dl-propranolol hydrochloride, atropine sulfate salt monohydrate, and indomethacin (Sigma-Aldrich Co., St. Louis, MO, USA); and BSA (fatty acid free, pH 7.0; Nacalai Tesque Inc., Kyoto, Japan).
PAF was dissolved in ethanol (EtOH) to prepare a stock solution of 2 × 10−3 M and stored at −80°C. When using PAF, the EtOH solvent was evaporated, and PAF was redissolved and diluted with 0.25% BSA to prepare solutions of 2 × 10−4–2 × 10−7 M. indomethacin was dissolved in EtOH to prepare a stock solution of 10−2 M. All other drugs were dissolved and diluted with distilled water.
Liu G., Kaneko M., Yoshioka K., Obara K, & Tanaka Y. (2022). Platelet-activating factor (PAF) strongly enhances contractile mechanical activities in guinea pig and mouse urinary bladder. Scientific Reports, 12, 2783.
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6

Pharmacological Manipulation of Fear Memory

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Midazolam (GobbiNovag S.A.) was diluted in sterile saline (SAL, 0.9% w/v) to a concentration of 3mg/ml and given intraperitoneally (i.p; Bustos et al., 2010 (link)).
DL-Propranolol hydrochloride and D-cycloserine (Sigma-Aldrich) were both dissolved in SAL at concentrations of 10mg/ml and 5mg/ml, respectively, for i.p. injection (Debiec and LeDoux, 2004 (link); Bertotto et al., 2006 (link); Muravieva et al., 2010 (link)). The total volume of drug or an equivalent amount of SAL was 1.0ml/kg in all cases.
For intra-BLA infusions, PROP was dissolved in SAL to a final dose of 5 ug/ul and the amount infused was 1.25 ug/side (Debiec and LeDoux, 2004 (link)).
Ortiz V., Giachero M., Espejo P.J., Molina V.A, & Martijena I.D. (2015). The Effect of Midazolam and Propranolol on Fear Memory Reconsolidation in Ethanol-Withdrawn Rats: Influence of D-Cycloserine. International Journal of Neuropsychopharmacology, 18(4), pyu082.
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7

Neurochemical Analysis Protocol

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6-OHDA hydrobromide, DL-propranolol hydrochloride, phentolamine hydrochloride, guanidine hydrochloride, DL alanine, α-ketoglutaric acid, sodium pyruvate, 2,4-dinitrophenilhydrazine, metaphosphoric acid, 2-propanol and 1-bromo-3-chloropropane (Sigma Chemical, St. Louis, MO, USA).
Aldaba-Muruato L.R., Muñoz-Ortega M.H., Macías-Pérez J.R., Pulido-Ortega J., Martínez-Hernández S.L, & Ventura-Juárez J. (2017). Adrenergic regulation during acute hepatic infection with Entamoeba histolytica in the hamster: involvement of oxidative stress, Nrf2 and NF-KappaB. Parasite, 24, 46.
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