Pns 7000

Manufactured by Nihon Kohden

Sourced in Japan

The PNS-7000 is a nerve stimulator device manufactured by Nihon Kohden. It is designed to provide electrical stimulation for the purpose of nerve localization and monitoring during medical procedures.

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Lab products found in correlation

Nm 983 w, by Nihon Kohden (2 mentions) Nm 980w, by Nihon Kohden (1 mentions)

4 protocols using pns 7000

Electrical Stimulation for Nociceptive Perception

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For nociceptive stimulation, an IES method was adopted using a disposable concentric bipolar needle electrode (NM-983W; Nihon Kohden Corp., Tokyo, Japan) which was connected to a specific stimulator for cutaneous Aδ and C fibers as previously described (PNS-7000; Nihon Kohden) (15 (link)).
The stimulator was composed of an outer ring anode (1.2 mm diameter), and the cathode of an inner needle that protruded 0.1 mm from the level of the outer ring. We placed the IES electrode onto the skin of the instep (over the extensor digitorum brevis) and then delivered weak continuous electrical stimulations. If the keratinized layer of the skin was too thick to interrupt the electronic stimulation, the electrode was moved elsewhere on the same foot to where there was seemingly no thick layer. Stimulation intensity was decreased by 0.05 mA stepwise from 0.2 mA until the participants reported a pricking sensation. P-IES was defined as the minimum intensity at which the participants felt a pricking sensation in more than two trials.

Itabashi C., Mizukami H., Osonoi S., Takahashi K., Kudo K., Wada K., Inaba W., Danyang G., Uchida C., Umetsu S., Igawa A., Ogasawara S., Ryuzaki M., Komeda K., Ishibashi Y., Yagihashi S, & Nakaji S. (2019). Normal High HbA1c a Risk Factor for Abnormal Pain Threshold in the Japanese Population. Frontiers in Endocrinology, 10, 651.

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Assessing Nociceptive Electrical Stimulation

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For nociceptive stimulation, IES method was adopted using a disposable concentric bipolar needle electrode (NM‐983W; Nihon Kohden Corporation, Tokyo, Japan), connected to a specific stimulator for cutaneous Aδ and C fibers, as previously described (PNS-7000, Nihon Kohden).12 (link) The stimulator consisted of an outer ring anode (1.3 mm diameter) and the cathode of an inner needle that protruded 0.025 mm from the level of the outer ring. IES electrode was placed onto the skin of the instep (over the extensor digitorum brevis) to deliver weak continuous electrical stimulations. This stimulation can evoke a local pricking sensation. In instances where the keratinized layer of the skin was too thick and likely to interrupt the electronic stimulation, the electrode was moved elsewhere on the same foot to locate an area of seemingly no thick layer. The participants were instructed to push the button as quickly as possible only when they felt a sensation. Stimulation intensity was decreased by 0.05 mA stepwise from 0.4 mA until the participants reported a pricking sensation. The current intensity is directly proportion to the intensity of stimulation. PINT was defined as the minimum intensity at which the participants felt a pricking sensation in more than two trials. Therefore, PINT can basically evaluate the degrees of hypoalgesia toward electrical pain stimulation.

Kudoh K., Mizukami H., Itabashi C., Fuke N., Osonoi S., Takeuchi Y., Wada K., Igawa A., Ogasawara S., Ishibashi Y., Hakamada K., Yagihashi S, & Nakaji S. (2020). Lipopolysaccharide-binding protein is a distinctive biomarker of abnormal pain threshold in the general Japanese population. BMJ Open Diabetes Research & Care, 8(1), e001739.

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Nociceptive Stimulation with Intra-Epidermal Electrical Stimulation

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For nociceptive stimulation, we used IES, which selectively activates Aδ fibers when low stimulation current intensities are applied (Inui et al., 2002 (link); Mouraux, Iannetti & Plaghki, 2010 (link)). The stimulus was delivered using a stimulator (PNS-7000; Nihon Kohden) and a stainless steel concentric bipolar needle electrode (NM-980W; Nihon Kohden). The stimulus was a train of triple triangular wave pulses (a rise and fall time of 0.5 ms) with an ISI of 5 ms. The stimulus intensity was 1.5–2.25 times the sensory threshold (0.07 ± 0.02 mA). The sensory threshold was determined as follows: we started with an intensity of 0.01 mA and increased it by 0.01 mA until the subject felt a pricking sensation; the intensity was then reduced by 0.01 mA until the subject’s pricking sensation disappeared; we determined the stimulus intensity at which subjects felt pricking sensations and obtained clear middle-to-late EPs (Inui et al., 2002 (link)) at 1.5–2.25 times the sensory threshold. We performed 15 IESs with an interval of 10–15 s.

Shiroshita Y., Kirimoto H., Watanabe T., Yunoki K, & Sobue I. (2021). Event-related potentials evoked by skin puncture reflect activation of Aβ fibers: comparison with intraepidermal and transcutaneous electrical stimulations. PeerJ, 9, e12250.

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Transcranial Stimulation Effects on Evoked Potentials

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Participants sat in a comfortable recliner with mounted head and arm rests, and all experiments were performed with the forearm in a neutral position. All subjects received one tSMS each over M1 and S1 (real tSMS), as well as sham stimulation, for 15 min in a counter-balanced order. To avoid carryover effects, each volunteer completed three sessions on separate days that were each at least 7 days apart. For recording of nociceptive evoked potentials from the cranial vertex, IES was applied to the dorsum of the right hand using a stainless steel concentric bipolar needle electrode (PNS-7000; Nihon Kohden, Tokyo, Japan) immediately after tSMS/sham stimulation. intra-epidermal electrical stimulation-evoked potential (IES-EP) recordings, sensory threshold measurement and scoring of VAS of perceived sensations were performed before, immediately after, and 10 min after tSMS and sham stimulation (Figure 1).

Kirimoto H., Tamaki H., Otsuru N., Yamashiro K., Onishi H., Nojima I, & Oliviero A. (2018). Transcranial Static Magnetic Field Stimulation over the Primary Motor Cortex Induces Plastic Changes in Cortical Nociceptive Processing. Frontiers in Human Neuroscience, 12, 63.

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