Nirmatrelvir

Manufactured by Pfizer

Sourced in Egypt

Nirmatrelvir is a laboratory product developed by Pfizer. It is a synthetic compound that functions as a protease inhibitor. This product is intended for use in research and development activities, and its core function is to inhibit the activity of specific enzymes. Detailed information about intended use or applications is not available.

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Lab products found in correlation

Ritonavir, by Pfizer (2 mentions) Paxlovid tablets, by Pfizer (2 mentions) Pink oval nirmatrelvir film coated tablet, by Pfizer (2 mentions) White ritonavir film coated tablet, by Pfizer (2 mentions) β cyclodextrin β cd, by Merck Group (1 mentions) Chloroform, by Merck Group (1 mentions) Ethanol, by Merck Group (1 mentions) Methanol, by Merck Group (1 mentions) Acetonitrile, by Merck Group (1 mentions) Hplc grade ethanol, by Merck Group (1 mentions)

Spelling variants of this product

Pink oval nirmatrelvir film-coated tablet (2 citations)

4 protocols using nirmatrelvir

Analytical Method Development for Paxlovid

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Pure reference standard of nirmatrelvir (99.36%) and ritonavir (99.62%) were kindly supplied by Pfizer, Inc, Egypt. The purity was checked by applying the reported method [13 ].

Paxlovid tablets, pink oval nirmatrelvir film-coated tablet (150 mg) co-packaged with white ritonavir film-coated tablet (100 mg), (B. NO: A1324, manufactured by Pfizer Company), were kindly supplied by Pfizer, Inc., Egypt. The recommended dose is two tablets of nirmatrelvir plus one tablet of ritonavir.

Acetonitrile, chloroform, ethanol and methanol (Sigma-Aldrich, Germany).

Tween 80, Sodium dodecyl sulphate “SDS”, El-Nasr Company, Egypt. Cetyl trimethyl ammonium bromide “CTAB” (Win lab, UK). β-cyclodextrin “β-CD”, Sigma-Aldrich, Germany.

Hydrochloric acid and Sodium hydroxide, El-Nasr Company, Egypt. 0.1 N aqueous solutions were prepared.

Boric acid, glacial acetic acid, potassium chloride acid and sodium acetate trihydrate, El-Nasr Company, Egypt.

Acetate buffer solutions in the pH range 4 to 6 and alkaline borate buffer in the pH range 8 to 10.

Drug-free human plasma of healthy volunteers was supplied by Blood Bank, Al-Azhar University Hospital, Damietta, Egypt.

Imam M.S., Abdelazim A.H., Ramzy S., Almrasy A.A., Gamal M, & Batubara A.S. (2023). Higher sensitive selective spectrofluorometric determination of ritonavir in the presence of nirmatrelvir: application to new FDA approved co-packaged COVID-19 pharmaceutical dosage and spiked human plasma. BMC Chemistry, 17(1), 120.

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Synthesis and Formulation of Nirmatrelvir

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Nirmatrelvir was synthesized at Excenen (China). In addition, a 1:1 MTBE solvate form of Nirmatrelvir was kindly provided by Pfizer. The Excenen batch was used for the first experiment and the MTBE solvate form Pfizer was used for the second experiment. Nirmatrelvir (Excenen) was formulated as 100 mg/ml in a vehicle containing 43% ethanol, 27% propyele glycol (Sigma) in sterile distilled water. The MTBE solvate form (Pfizer) was formulated as 40 mg/ml suspension in 2% (v/v) Tween80 in 98% (v/v) of 0.5% (w/v) Methyl Cellulose by geometric dilution.

Abdelnabi R., Jochmans D., Donckers K., Trüeb B., Ebert N., Weynand B., Thiel V, & Neyts J. (2023). Nirmatrelvir-resistant SARS-CoV-2 is efficiently transmitted in female Syrian hamsters and retains partial susceptibility to treatment. Nature Communications, 14, 2124.

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HPLC Analysis of Nirmatrelvir and Ritonavir

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Pure reference standard of nirmatrelvir (99.36%) and ritonavir (99.62%) were kindly supplied by Pfizer, Inc, Egypt.
Paxlovid tablets, pink oval nirmatrelvir film-coated tablet (150 mg) co-packaged with white ritonavir film-coated tablet (100 mg), (B. NO: A1324, manufactured by Pfizer Company), were kindly supplied by Pfizer, Inc., Egypt. The recommended dose is two tablets of nirmatrelvir plus one tablet of ritonavir.
Ethanol, HPLC grade was supplied by Sigma Aldrich, Germany. Water used throughout the procedure was freshly distilled.

Imam M.S., Batubara A.S., Gamal M., Abdelazim A.H., Almrasy A.A, & Ramzy S. (2023). Adjusted green HPLC determination of nirmatrelvir and ritonavir in the new FDA approved co-packaged pharmaceutical dosage using supported computational calculations. Scientific Reports, 13, 137.

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Randomized Trial of Nirmatrelvir-Ritonavir

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Eligible patients were randomly assigned in a 1:1 ratio, by means of an interactive response technology system, to receive either Nirmatrelvir plus ritonavir or matched placebo every 12 hours for 5 days (10 doses total). Randomization was stratified by geographic region and by receipt or expected receipt (based on investigator opinion) of Covid-19 monoclonal antibodies. Nirmatrelvir and matching placebo were manufactured by Pfizer, ritonavir tablets were manufactured and tested by Hetero Labs, and blinding of the tablets was performed by Pfizer through over-encapsulation. The assessment schedule is outlined in Figure S1.

Hammond J., Leister-Tebbe H., Gardner A., Abreu P., Bao W., Wisemandle W., Baniecki M., Hendrick V.M., Damle B., Simón-Campos A., Pypstra R, & Rusnak J.M. (2022). Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19. The New England Journal of Medicine.

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