Progesterone

Manufactured by Tokyo Chemical Industry

Sourced in Japan

Progesterone is a steroid hormone used in various laboratory applications. It functions as a key component in the synthesis and analysis of other compounds, playing a critical role in numerous biochemical processes.

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Lab products found in correlation

Poly vinyl alcohol pva, by Polysciences (2 mentions) Streptozotocin (stz), by Santa Cruz Biotechnology (1 mentions) Dexamethasone (dex), by Merck Group (1 mentions) Glucagon, by Merck Group (1 mentions) Sodium pyruvate, by Merck Group (1 mentions) Testosterone, by Fujifilm (1 mentions) Phenanthrene, by Tokyo Chemical Industry (1 mentions) Ibuprofen, by Fujifilm (1 mentions) Dehydroabietic acid, by Fujifilm (1 mentions) Methyltestosterone, by Tokyo Chemical Industry (1 mentions) Barnstead smart2pure system, by Thermo Fisher Scientific (1 mentions) Abietic acid, by Tokyo Chemical Industry (1 mentions) Pyrene, by Merck Group (1 mentions) Yeast nitrogen base without amino acids, by Formedium (1 mentions) Cortisol, by Nacalai Tesque (1 mentions) 6β hydroxytestosterone, by Merck Group (1 mentions) 6β hydroxycortisol, by Merck Group (1 mentions) Sodium dodecyl sulfate (sds), by Merck Group (1 mentions) 7525 dlg 4a, by Evonik (1 mentions)

5 protocols using progesterone

Reagents for Cell Experiments

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MDL-12,330A hydrochloride was purchased from Tocris Bioscience. Progesterone was purchased from Tokyo Chemical Industry. Streptozotocin was purchased from Santa Cruz Biotechnology. Sodium pyruvate, glucagon, and dexamethasone were purchased from Sigma-Aldrich.

Lee S.R., Choi W.Y., Heo J.H., Huh J., Kim G., Lee K.P., Kwun H.J., Shin H.J., Baek I.J, & Hong E.J. (2020). Progesterone increases blood glucose via hepatic progesterone receptor membrane component 1 under limited or impaired action of insulin. Scientific Reports, 10, 16316.

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Procurement of Diverse Chemical Compounds

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Abietic acid, ADD, DHEA, methyl testosterone,
phenanthrene, and progesterone were purchased from Tokyo Chemical
Industry (Tokyo, Japan). DehydroAbietic acid, dibenzothiophene, 7-ethoxycoumarin,
ibuprofen, and testosterone were purchased from Fujifilm Wako Pure
Chemical (Osaka, Japan). Pyrene was purchased from Sigma-Aldrich Japan
(Tokyo, Japan). Diclofenac was purchased from Combi-Blocks USA (San
Diego, CA, USA). Ferruginol was kindly provided by Dr. H. Suhara (Miyazaki
Prefectural Wood Utilization Research Center, Japan). Yeast nitrogen
base without amino acids was purchased from Formedium (Hunstanton,
UK). Dropout supplements (DOS) were purchased from TaKaRa Bio USA
(Mountain View, CA, USA). Custom-synthesized oligonucleotide primers
were obtained from Sigma-Aldrich Japan. All other chemicals were of
reagent grade. Deionized water was obtained using a Barnstead Smart2Pure
System (Thermo Fisher Scientific, Waltham, MA, USA).

Permana D., Niesel K., Ford M.J, & Ichinose H. (2022). Latent Functions and Applications of Cytochrome P450 Monooxygenases from Thamnidium elegans: A Novel Biocatalyst for 14α-Hydroxylation of Testosterone. ACS Omega, 7(16), 13932-13941.

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CYP3A4 and CYP3A5 Enzyme Assay

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CYP3A4 and CYP3A5 expressed in recombinant Escherichia coli (Bactosomes) were obtained from Cypex Ltd (Dundee, UK). Testosterone and cortisol were purchased from Nakarai Tesque (Kyoto, Japan) and Fujifilm Wako Pure Chemicals (Osaka, Japan), respectively. Metabolites 6β-hydroxytestosterone and 6β-hydroxycortisol were obtained from Sigma-Aldrich (St Louis, MO, USA). Progesterone and 6βhydroxyProgesterone were purchased from Tokyo Chemical Industry (Tokyo, Japan) and Steraloids Inc. (Newport, RI USA), respectively. All other reagents and organic solvents used were of the highest purity commercially available.

Niwa T., Narita K., Okamoto A., Murayama N, & Yamazaki H. (2019). Comparison of Steroid Hormone Hydroxylations by and Docking to Human Cytochromes P450 3A4 and 3A5. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 22(1).

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Progesterone-loaded PLGA Nanoparticles

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Poly-d,l-lactide-co-glycolide (PLGA) with a lactide:glycolide ratio of 75:25 (7525DLG 4A; inherent viscosity, 0.4 dL/g in CHCl₃ at 25 °C) was purchased from Evonik Degussa Corp. (Birmingham, AL, USA). Polyvinyl alcohol (PVA; 88% hydrolyzed, Mw = 25,000 g/mol) was supplied from Polysciences, Inc. (Warrington, PA, USA). Progesterone was purchased from TCI Chemicals (Tokyo, Japan). Ethyl formate (EF) and sodium dodecyl sulfate (SDS) were from Sigma-Aldrich Korea (Seoul, Korea). Ethyl acetate (EA) was purchased from Avantor Performance Materials Korea, Ltd. (Suwon, Korea).

Shim H, & Sah H. (2020). Qualification of Non-Halogenated Organic Solvents Applied to Microsphere Manufacturing Process. Pharmaceutics, 12(5), 425.

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Progesterone-Loaded PLGA Nanoparticle Synthesis

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75:25DLG 4A (PLGA with a lactide/glycolide ratio of 75:25; inherent viscosity, 0.4 dL/g in CHCl₃ at 25 °C) was supplied from Evonik Degussa Corp. (Birmingham, AL, USA). This polymer is abbreviated as PLGA in the text. Polyvinyl alcohol (PVA; 88% hydrolyzed, Mw = 25,000 g/mol) was obtained from Polysciences, Inc. (Warrington, PA, USA). Ethyl formate was from Sigma-Aldrich Korea (Seoul, Korea). Progesterone and methylene chloride were procured from TCI Chemicals (Tokyo, Japan) and Showa Denko (Tokyo, Japan), respectively.

Shim H, & Sah H. (2020). Assessment of Residual Solvent and Drug in PLGA Microspheres by Derivative Thermogravimetry. Pharmaceutics, 12(7), 626.

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