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N n diisopropylethylamine

Manufactured by Iris Biotech
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Sourced in Germany

N,N-diisopropylethylamine is a commonly used organic base in chemical synthesis. It functions as a non-nucleophilic hindered amine base, commonly used as a proton scavenger and acid acceptor in organic reactions.

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Lab products found in correlation

Trifluoroacetic acid, by Iris Biotech (4 mentions) Piperidine, by Iris Biotech (3 mentions) Rink amide chemmatrix resin, by Biotage (2 mentions) Rink amide resin, by Iris Biotech (2 mentions) Wang resin, by Iris Biotech (1 mentions) Nα fmoc protected amino acids, by Iris Biotech (1 mentions) Triisopropylsilane, by Iris Biotech (1 mentions) Diethyl ether, by Thermo Fisher Scientific (1 mentions) Methanol, by Thermo Fisher Scientific (1 mentions) Rink amide linker, by Iris Biotech (1 mentions)

4 protocols using n n diisopropylethylamine

1

Automated Peptide Synthesis Workflow

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Nα-Fmoc-protected amino acids, resins, coupling reagents, N,N-diisopropylethylamine (DIEA), piperidine, and trifluoroacetic acid (TFA) were purchased from Iris Biotech (Marktredwitz, Germany). Fmoc-Ala-Wang resin was purchased from Novabiochem®. Rink amide ChemMatrix resin was purchased from Biotage. Peptide-synthesis solvents and reagents, as well as acetonitrile (CH3CN) for HPLC, were reagent grade and were acquired from commercial sources and used without further purification unless otherwise noted.
Vivenzio G., Scala M.C., Marino P., Manfra M., Campiglia P, & Sala M. (2023). Dipropyleneglycol Dimethylether, New Green Solvent for Solid-Phase Peptide Synthesis: Further Challenges to Improve Sustainability in the Development of Therapeutic Peptides. Pharmaceutics, 15(6), 1773.
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2

Solid-Phase Peptide Synthesis

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Nα-Fmoc-protected amino acids, Wang resin, Rink amide-resin, coupling reagents, N,N-Diisopropylethylamine (DIEA), piperidine and trifluoroacetic acid (TFA) were purchased from Iris Biotech (Germany). Rink Amide-ChemMatrix resin was purchased from Biotage AB (Sweden). Peptide synthesis solvents, reagents, as well as CH3CN for High Performance Liquid Chromatography (HPLC) were reagent grade and were acquired from commercial sources and used without further purification unless otherwise noted.
Scala M.C., Sala M., Pietrantoni A., Spensiero A., Di Micco S., Agamennone M., Bertamino A., Novellino E., Bifulco G., Gomez-Monterrey I.M., Superti F, & Campiglia P. (2017). Lactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors. Scientific Reports, 7, 10593.
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3

Solid-Phase Peptide Synthesis

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Nα-Fmoc-protected amino acids, Rink amide resin, coupling reagents, N,N-diisopropylethylamine (DIEA), piperidine and trifluoroacetic acid (TFA) were purchased from Iris Biotech (Marktredwitz, Germany). Peptide synthesis solvents, reagents and CH3CN for high-performance liquid chromatography (HPLC) were reagent grade, acquired from commercial sources and used without further purification unless otherwise noted.
Scala M.C., Agamennone M., Pietrantoni A., Di Sarno V., Bertamino A., Superti F., Campiglia P, & Sala M. (2021). Discovery of a Novel Tetrapeptide against Influenza A Virus: Rational Design, Synthesis, Bioactivity Evaluation and Computational Studies. Pharmaceuticals, 14(10), 959.
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4

Solid-Phase Peptide Synthesis of DOTA Conjugates

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Amino acids protected by 9-fluorenylmethyloxy carbonyl (Fmoc) where purchased from NovaBiochem, Watford, UK. Tenta Gel S NH2 resin and Rink amide linker were purchased from Iris Biotech, Marktredwitz, Germany. Dimethylformamide (DMF), dichloromethane, diethyl ether, and methanol were of analytical grade (≥99.5%) and obtained from Fisher Scientific, Loughborough, UK. Triisopropylsilane (TIPS, ≥98.0% GC), phenol (≥99%), trifluoroacetic acid (TFA, ≥99%), and N,N-diisopropylethylamine (DIPEA, ≥99%) were obtained from Iris Biotech GmbH. 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU, ≥97%) was purchased from NovaBiochem, UK. Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (DOTA-tri-t-Bu-ester) was purchased from Sigma Aldrich, Dorset, UK. All other reagents were of analytical grade.
Mbundi L., Meikle S.T., Busquets R., Dowell N.G., Cercignani M, & Santin M. (2018). Gadolinium Tagged Osteoprotegerin-Mimicking Peptide: A Novel Magnetic Resonance Imaging Biospecific Contrast Agent for the Inhibition of Osteoclastogenesis and Osteoclast Activity. Nanomaterials, 8(6), 399.
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