Small animal oct

Manufactured by Thorlabs

Sourced in Germany

The Small Animal OCT is an imaging system designed for non-invasive, high-resolution imaging of the eye and other structures in small animals. It utilizes optical coherence tomography (OCT) technology to capture cross-sectional images of the sample.

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Lab products found in correlation

Micron 3, by Phoenix Pharmaceuticals (4 mentions) Fluorescein, by Alcon (2 mentions) Micron 3, by Alcon (2 mentions)

4 protocols using small animal oct

Retinal Imaging Techniques for Laser-Induced CNV

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All examinations were conducted under general anesthesia. All mice were examined by funduscopy using a contact fundus camera (MICRON III; Phoenix Research Labs, Pleasanton, CA). The integrity of the retina was assessed, the number of drusen-like retinal spots (DRS) was counted, RPE atrophy evaluated, and CNV noted.
Optical coherence tomography (OCT; small animal OCT; Thorlabs, Lübeck, Germany) was applied via contact optics to evaluate the retinal structure, confirm retinal integrity after laser treatment, and to confirm CNV. After laser treatment, it was used to investigate anatomic integrity of retinal layers. Retinal layer borders were determined and marked manually by a blinded investigator. Outer nuclear layer thickness was measured in a blinded standardized manner manually, using Thorlabs OCT software. Four measurements in each eye were carried out at 400 and 600 μm temporal as well as 400 and 600 μm nasal to the optic disc, before and 1 month after SRT. Thickness mean was compared by Student's t-test.
Fluorescein (10% Fluorescein, 60-mg/kg bodyweight in 100 μL saline intraperitoneally; Alcon Pharma, Freiburg, Germany) angiography (FLA; MICRON III) was performed after laser treatment to evaluate vessel integrity, to detect vessel leakage, and to confirm possible CNV formation.
All examinations were repeated at the day of enucleation, thus 1 month after laser treatment.

Tode J., Richert E., Koinzer S., Klettner A., von der Burchard C., Brinkmann R., Lucius R, & Roider J. (2019). Selective Retina Therapy Reduces Bruch's Membrane Thickness and Retinal Pigment Epithelium Pathology in Age-Related Macular Degeneration Mouse Models. Translational Vision Science & Technology, 8(6), 11.

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Retinal Integrity Assessment in AMD Mouse Model

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All examinations were conducted under general anesthesia. All mice were examined by funduscopy (MICRON III, phoenix research labs, Pleasanton, CA, USA), to assess integrity of retina, hallmarks of AMD (drusen-like retinal spots (DRS)), RPE atrophy and CNV.
Optical coherence tomography (OCT) (small animal OCT, thorlabs, Lübeck, Germany) was applied to evaluate retinal structure, confirm retinal integrity after laser treatment and to confirm CNV.
All examinations were repeated at the day of enucleation, thus 1 day or 1 week after laser treatment. Untreated controls also were examined twice, at inclusion and at enucleation day.

Richert E., Papenkort J., von der Burchard C., Klettner A., Arnold P., Lucius R., Brinkmann R., Framme C., Roider J, & Tode J. (2021). Selective retina therapy and thermal stimulation of the retina: different regenerative properties - implications for AMD therapy. BMC Ophthalmology, 21, 412.

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Comprehensive Retinal Assessment in Mice

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All examinations were conducted under general anesthesia. All mice were examined by funduscopy using a contact fundus camera (MICRON III, phoenix research labs, Pleasanton, CA, USA). The integrity of the retina was assessed, the number of drusen-like retinal spots (DRS) was counted, RPE atrophy evaluated, and CNV noted.
Optical coherence tomography (OCT) (small animal OCT, thorlabs, Lübeck, Germany) was applied via contact optics to evaluate the retinal structure, confirm retinal integrity after laser treatment, and to confirm CNV. After laser treatment, it was used to investigate anatomical integrity of retinal layers.
All examinations were repeated at the day of enucleation, thus 1 day or 1 week after laser treatment. Untreated controls also were examined twice, at inclusion and at enucleation day.

Richert E., von der Burchard C., Klettner A., Arnold P., Lucius R., Brinkmann R., Roider J, & Tode J. (2020). Modulation of inflammatory processes by thermal stimulating and RPE regenerative laser therapies in age related macular degeneration mouse models. Cytokine, 2(3), 100031.

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Retinal Imaging in Laser-Induced CNV

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All examinations were conducted under general anesthesia. All mice were examined by funduscopy using a contact fundus camera (MICRON III, Phoenix Research Labs, Pleasanton, CA). The integrity of the retina was assessed, the number of drusen-like retinal spots (DRS) was counted, RPE atrophy evaluated, and CNV noted.
Optical coherence tomography (OCT) (small animal OCT, Thorlabs, Lübeck, Germany) was applied via contact optics to evaluate the retinal structure, confirm retinal integrity after laser treatment, and to confirm CNV. After laser treatment, it was used to investigate anatomical integrity of retinal layers.
Fluorescein (10% Fluorescein, 60 mg/kg body weight in 100 μL saline intraperitoneally; Alcon Pharma, Freiburg, Germany) angiography (FLA) (MICRON III) was performed after laser treatment to evaluate vessel integrity, to detect vessel leakage, and to confirm possible CNV formation.
All examinations were repeated at the day of enucleation, thus 1 month after laser treatment.

Tode J., Richert E., Koinzer S., Klettner A., von der Burchard C., Brinkmann R., Lucius R, & Roider J. (2018). Thermal Stimulation of the Retina Reduces Bruch's Membrane Thickness in Age Related Macular Degeneration Mouse Models. Translational Vision Science & Technology, 7(3), 2.

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