Carbenoxolone disodium

Manufactured by LKT Laboratories

Sourced in United States, Sao Tome and Principe

Carbenoxolone disodium is a chemical compound used in various laboratory applications. It is a white crystalline solid that is soluble in water. The core function of carbenoxolone disodium is to serve as a research tool in scientific investigations, though its specific applications may vary depending on the research context.

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Lab products found in correlation

St2825, by Apexbio (1 mentions) Resatorvid tak 242, by MedChemExpress (1 mentions) β tubulin, by Cell Signaling Technology (1 mentions)

2 protocols using carbenoxolone disodium

Carbenoxolone administration in dogs

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In the CBX group, all dogs were administrated carbenoxolone disodium (LKT Laboratories, Inc., Saint Paul, MN, USA) capsuled orally twice a day with food. The dose given was 100mg/kg/day CBX for 15 days. During the administration period, general conditions were monitored daily.

Teshima T., Matsumoto H., Okusa T., Nakamura Y, & Koyama H. (2015). Effects of Carbenoxolone on the Canine Pituitary-Adrenal Axis. PLoS ONE, 10(8), e0135516.

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Inflammation Signaling Pathway Inhibitors

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Resatorvid (TAK-242) and Ibudilast were purchased from MedChem Express (Monmouth Junction, NJ). ST-2825 was purchased from Apexbio Technology (Houston, TX). Carbenoxolone disodium was purchased from LKT Laboratories (St. Paul, MN). Most antibodies were purchased from Cell Signaling including phospho-NF-κB p65 (3033), phospho-p38 (9215), phospho-Akt (4060), phospho-JNK (9255), and beta tubulin (5666). The antibody for TLR4 western blots (sc-293072) was purchased from Santa Cruz Biotechnology (Dallas, TX), and the antibody for TLR4 IHC (ab22048) was purchased from Abcam (Cambridge, MA).

Janda J., Burkett N., Blohm-Mangone K., Huang V., Curiel-Lewandrowski C., Alberts D.S., Petricoin EF I.I.I., Calvert V.S., Einspahr J., Dong Z., Bode A.M., Wondrak G.T, & Dickinson S.E. (2016). Resatorvid-based Pharmacological Antagonism of Cutaneous TLR4 Blocks UV-induced NF-κB and AP-1 Signaling in Keratinocytes and Mouse Skin. Photochemistry and photobiology, 92(6), 816-825.

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