Ex-4, nimodipine, Ex-9-39 and BayK-8644 were purchased from MedChemExpress (Monmouth Junction, NJ, USA), while TTX, Ryanodine, W-7 and U-73122 were from Tocris Bioscience (Ellisville, MO, USA). NF-449 was purchased from Cayman Chemical (Ann Arbor, MI, USA) and C2 Ceramide from Santa Cruz (Dallas, TX, USA). The others were purchased from Sigma-Aldrich. nimodipine, Bis-IV, U-73122, Ryanodine, W-7, FK-506, OA, and C2 Ceramide were initially dissolved in DMSO for stock. The final concentration of DMSO was less than 0.1%, with no effects on the calcium currents of RGCs. All other drug solutions were prepared in ion-free water, stored at −20°C and freshly diluted to the final concentrations using extracellular or intracellular solutions. For topical ocular administration, Ex-4 and Ex-9-39 were dissolved in saline, and BayK-8644 was dissolved in 50% PEG-400 diluted with saline.
Nimodipine
Manufactured by MedChemExpress
Sourced in United States
Nimodipine is a laboratory reagent used in research applications. It is a dihydropyridine calcium channel blocker. Nimodipine helps regulate the flow of calcium ions into certain muscle cells.
Automatically generated - may contain errors
2 protocols using nimodipine
1
Neuromodulators and Calcium Signaling in Retinal Ganglion Cells
2
Eupafolin Protects Against LPS-Induced Injury
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Adult male Sprague-Dawley rats (7–8 week-old; n=48) weighing 250–280 g were supplied by Nanjing Better Biotechnology Co., Ltd, and were acclimatized for 1 week before experiments at room temperature under a controlled 12/12 h light/dark cycle. All rats received food and water ad libitum. The experimental protocols involving rats were approved by the Animal Studies Ethics Committee of the Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine.
The animals were randomly assigned to six groups (n=8 for each group): Control, model, 10 mg/kg eupafolin (purity >98%; Shanghai Rongbia Biological Technology Co., Ltd.), 20 mg/kg eupafolin, 50 mg/kg eupafolin and 20 mg/kg nimodipine (MedChemExpress). The control group underwent sham surgery. eupafolin and nimodipine were intragastrically (i.g.) administered into the rats once a day for 7 consecutive days. The control and model groups were administered 200 µl normal saline i.g. For the eupafolin + lipopolysaccharide (LPS) group, the animals were intraperitoneally injected with 50 µg/kg LPS (21 (link)) at the same time that they received eupafolin 20 mg/kg for the last time.
The animals were randomly assigned to six groups (n=8 for each group): Control, model, 10 mg/kg eupafolin (purity >98%; Shanghai Rongbia Biological Technology Co., Ltd.), 20 mg/kg eupafolin, 50 mg/kg eupafolin and 20 mg/kg nimodipine (MedChemExpress). The control group underwent sham surgery. eupafolin and nimodipine were intragastrically (i.g.) administered into the rats once a day for 7 consecutive days. The control and model groups were administered 200 µl normal saline i.g. For the eupafolin + lipopolysaccharide (LPS) group, the animals were intraperitoneally injected with 50 µg/kg LPS (21 (link)) at the same time that they received eupafolin 20 mg/kg for the last time.
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!