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B6 cba tg tbx21 cre 1dlc j tbet cre

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The B6;CBA-Tg(Tbx21-cre)1Dlc/J (Tbet-cre) mouse strain expresses Cre recombinase under the control of the T-box expressed in T cells (Tbx21) gene promoter, which is specifically expressed in T helper 1 (Th1) cells. This mouse strain can be used to perform cell-specific genetic manipulations in Th1 cells.

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C57bl 6j female mice, by Jackson ImmunoResearch (2 mentions)

2 protocols using b6 cba tg tbx21 cre 1dlc j tbet cre

1

Murine T-bet Fate Mapping Protocol

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C57BL/6J female mice aged 6–8 weeks old were purchased from Jackson Laboratories or bred in-house at La Jolla Institute for Immunology. B6;CBA-Tg(Tbx21-cre)1Dlc/J (Tbet-cre) were purchased from Jackson Laboratories and then bred with B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J (Td-tomato) mice (also obtained from Jackson Laboratories) to generate the T-bet fate mapping line. All studies were approved by the Institutional Animal Care and Use Committee at the La Jolla Institute for Immunology.
Murray M.P., Engel I., Seumois G., Herrera-De la Mata S., Rosales S.L., Sethi A., Logandha Ramamoorthy Premlal A., Seo G.Y., Greenbaum J., Vijayanand P., Scott-Browne J.P, & Kronenberg M. (2021). Transcriptome and chromatin landscape of iNKT cells are shaped by subset differentiation and antigen exposure. Nature Communications, 12, 1446.
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2

Tracing Tbet+ Cell Lineage

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C57BL/6J female mice aged 6-8 weeks old were purchased from Jackson Laboratories or bred in-house at La Jolla Institute for Immunology. B6;CBA-Tg(Tbx21-cre)1Dlc/J (Tbet-cre) were purchased from Jackson Laboratories and then bred with B6.Cg-Gt(ROSA)26Sor tm14(CAG-tdTomato)Hze/J (Td-tomato) mice (also obtained from approved by the Institutional Animal Care and Use Committee at the La Jolla Institute for Immunology.
Murray M., Engel I., Seumois G., Mata S.H.l., Rosales S.L., Sethi A., Premlal A.L.R., Seo G., Greenbaum J., Vijayanand P., Scott‐Browne J., & Kronenberg M. (2020). Transcriptome and Chromatin Landscape of iNKT cells are Shaped by Subset Differentiation and Antigen Exposure.
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