The mass spectrometric detection was carried out using a SCIEX 4500 or a SCIEX 5500 triple quadrupole mass spectrometer operating in positive electrospray ionization utilizing multiple reaction monitoring (MRM) mode. The LC and the mass spectrometer were controlled by Analyst software (version 1.6.2 and greater). The settings for the SCIEX 4500 or the SCIEX 5500 mass spectrometer are in Table 1 .
Sciex 4500
Manufactured by AB Sciex
The SCIEX 4500 is a high-performance liquid chromatography-tandem mass spectrometry (LCMS/MS) system. It is designed for accurate, sensitive, and robust quantitative analysis of small molecules. The SCIEX 4500 features a triple quadrupole mass analyzer that provides enhanced selectivity and sensitivity for targeted analyte detection and quantification.
Automatically generated - may contain errors
Lab products found in correlation
2 protocols using sciex 4500
1
Mass Spectrometric Detection Protocol
2
Compound Distribution in Anti-Infective Research
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Example 60
The distribution of compounds to target organs is of specific importance to the efficacy of anti-infective compounds. To determine distribution the compounds are formulated and administered to a suitable animal model. Compounds were administered p.o. 10 mg/kg in 2% citric acid in BALBc and organs were recovered at 6 h. Organs were extracted in Acetonitrile (6× volume of the sample), centrifuged at 14000 g for 5 minutes. Samples were analysed by LCMSMS (SCIEX 4500). Data are the mean of 3 animals.
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!