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Ly cov1404

Manufactured by Shanghai Model Organisms
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Sourced in China

LY-CoV1404 is a laboratory equipment designed for the detection and analysis of biological samples. It utilizes advanced sensing technologies to provide accurate and reliable data. The core function of LY-CoV1404 is to facilitate scientific research and investigation, allowing researchers to obtain valuable insights from their samples.

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Lab products found in correlation

Infinite 200 pro software, by Tecan (2 mentions) Phoenix winnonlin software, by Pharsight (2 mentions) Infinite 200 pro, by Tecan (1 mentions)

2 protocols using ly cov1404

1

Evaluating mAb Pharmacokinetics in Transgenic Mice

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Transgenic mice with human neonatal Fc receptor (hFcRn) overexpression (C57BL/6JSmoc-Fcgrtem2(hFCGRT)Smoc) (Vendor: Shanghai Model Organisms Center, China) were used to evaluate the pharmacokinetic profiles of mAbs XG005, XG005-CYLK, and LY-CoV1404 (bebtelovimab). Twenty-seven mice were randomly assigned into three groups and a single dose of mAbs (10 mg/kg) were administrated based on their body weights. The serums samples were collected on different time points, including -1-day pre-infusion and 2, 4, 8, 24, 48, 96, 168, 240, 336, 504, 672, 840 h post-infusion. Sample analysis was conducted utilizing validated ELISA methods. Sample concentration data was collected on the INFINITE 200 PRO plate reader and processed using INFINITE 200 PRO Software (2013) Tecan. Pharmacokinetic parameters were evaluated using a non-compartmental approach with Phoenix WinNonlin software (Version 8.0.0.3176, Pharsight, CA).
Wu J., Chen Z., Gao Y., Wang Z., Wang J., Chiang B.Y., Zhou Y., Han Y., Zhan W., Xie M., Jiang W., Zhang X., Hao A., Xia A., He J., Xue S., Mayer C.T., Wu F., Wang B., Zhang L., Sun L, & Wang Q. (2023). Fortuitous somatic mutations during antibody evolution endow broad neutralization against SARS-CoV-2 Omicron variants. Cell Reports, 42(5), 112503.
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2

Pharmacokinetic Evaluation of mAbs in Transgenic Mice

Check if the same lab product or an alternative is used in the 5 most similar protocols
Transgenic mice (C57BL/6JSmoc) with human neonatal Fc receptor (hFcRn) overexpression (Vendor: Shanghai Model Organisms Center, China) were used to evaluate the pharmacokinetic profiles of mAbs XG005, XG005-CYLK, and LY-CoV1404 (bebtelovimab). Twenty-seven mice were randomly assigned into three groups and a single dose of mAbs (10 mg/kg) were administrated based on their body weights. The serums samples were collected on different time points, including −1-day pre-infusion and 2, 4, 8, 24, 48, 96, 168, 240, 336, 504, 672, 840 hours post-infusion. Sample analysis was conducted utilizing validated ELISA methods. Sample concentration data was collected on the INFINITE 200 PRO plate reader and processed using INFINITE 200 PRO Software (2013) Tecan. Pharmacokinetic parameters were evaluated using a non-compartmental approach with Phoenix WinNonlin software (Version 8.0.0.3176, Pharsight, CA).
Wu J., Chen Z., Gao Y., Wang Z., Wang J., Chiang B.Y., Zhou Y., Han Y., Zhan W., Xie M., Jiang W., Zhang X., Hao A., Xia A., He J., Xue S., Mayer C.T., Wu F., Wang B., Zhang L., Sun L, & Wang Q. (2022). Fortuitous Somatic Mutations during Antibody Evolution Endow Broad Neutralization against SARS-CoV-2 Omicron Variants. bioRxiv.
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