All chemicals were obtained either from Sigma-Aldrich Corp. (St. Louis, MO, USA) or Merck KGaA (Darmstadt, Germany), and used without further chemical purification. Melting points of the compounds were measured by using an automatic melting point determination instrument (MP90, Mettler-Toledo, Columbus, OH, USA) and were presented as uncorrected. 1H- and 13C-NMR spectra were recorded in DMSO-d6 by a Bruker digital FT-NMR spectrometer (Bruker Bioscience, Billerica, MA, USA) at 300 MHz and 75 MHz, respectively. The IR spectra of the compounds were recorded using an IRAffinity-1S Fourier transform IR (FTIR) spectrometer (Shimadzu, Tokyo, Japan). MS studies were performed on an LCMS-8040 tandem mass system (Shimadzu, Tokyo, Japan). Chemical purities of the compounds were checked by classical TLC applications performed on silica gel 60 F254 (Merck KGaA).
Lcms 8040 tandem mass system
Manufactured by Shimadzu
Sourced in Japan
The LCMS-8040 tandem mass spectrometer is a high-performance liquid chromatography-mass spectrometry (LC-MS/MS) system. It is designed to provide rapid, sensitive, and reliable analysis of a wide range of compounds. The system combines a liquid chromatograph with a triple quadrupole mass spectrometer, enabling the separation, identification, and quantification of analytes in complex matrices.
Automatically generated - may contain errors
Lab products found in correlation
Silica gel 60 f254, by Merck Group (2 mentions)
Digital ft nmr spectrometer, by Bruker (2 mentions)
Ir affinity 1s infrared spectrophotometer, by Shimadzu (2 mentions)
Iraffinity 1s fourier transform ir ftir spectrometer, by Shimadzu (1 mentions)
Dgu 14a degasser, by Shimadzu (1 mentions)
Prominence hplc system, by Shimadzu (1 mentions)
Dmso d6, by Bruker (1 mentions)
Fourier 300, by Bruker (1 mentions)
4 protocols using lcms 8040 tandem mass system
1
Synthesis and Characterization of Organic Compounds
2
Comprehensive Characterization of Organic Compounds
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Melting points (m.p.) were determined on the Mettler Toledo-MP90 Melting Point System and were uncorrected. IR spectra were recorded on an IR Affinity-1S Infrared spectrophotometer (Shimadzu, Tokyo, Japan). 1H NMR and 13C NMR spectra in DMSO-d6 were recorded on a Bruker Fourier 300 (Bruker Bioscience, Billerica, MA, USA), respectively. MS studies were performed on an LCMS-8040 tandem mass system (Shimadzu, Tokyo, Japan). Chemical purities of the compounds were checked by classical TLC applications performed on silica gel 60 F254 (Merck KGaA, Darmstadt, Germany). The Rf values of the synthesized compounds were measured using the solution system of petroleum ether:ethyl acetate (1:1).
3
Synthesis and Characterization of Organic Compounds
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Chemicals of the Merck (Merck KGaA, Darmstadt, Germany) or Sigma-Aldrich (Sigma-Aldrich Corp., St. Louis, MO, USA) companies were used in the synthesis. The 1H-NMR and 13C-NMR spectra were recorded in DMSO-d6 at 300 MHz and 75 MHz, pespectively, on a digital FT-NMR spectrometer (Bruker Bioscience, Billerica, MA, USA). The NMR spectra signals were defined as a singlet (s), br.s. (broad singlet), doublet (d), triplet (t), double doublet (dd), and multiplet (m). The coupling constants (J) are reported in units of Hertz (Hz). A FT-IR spectrometer (IRAffinity-1S Fourier transform, Shimadzu, Tokyo, Japan) was used to record the IR spectra of the compounds. MS studies were performed on an LCMS-8040 tandem mass system (Shimadzu) and acetonitrile containing 0.1% formic acid was used as solvent. Silica gel 60 F254 by TLC (Merck KGaA) was used to monitor the progress of reactions.
4
Analytical Characterization of Organic Compounds
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All reagents were purchased from commercial suppliers and were used without further purification. Prominence HPLC system (Shimadzu, Kyoto, Japan), equipped with a Shimadzu DGU-14 A degasser, LC-20 A dual piston pump, CTO-10 ASVP column oven and SPD-MI20A PDA detector Sıl-20ACXR autosampler and a stainless-steel GL Science Inertsil ODS-3 (4.6 250 mm) column. Solvents (acetonitrile and water, 7:3) for the separation obtained compounds were isocritically mixed at a flow rate of 0.25 mL/min and injection were performed by volume of 10 µL. IR spectra was recorded on an IR Affinity-1S Infrared spectrophotometer (Shimadzu, Tokyo, Japan). Melting points (M.p.) were determined using the Mettler Toledo-MP90 Melting Point System and were uncorrected. 1H NMR and 13C NMR spectra was recorded on a Bruker Fourier 300 (Bruker Bioscience, Billerica, MA, USA) respectively, in DMSO-d6. (Bruker, Billerica, MA, USA), respectively. MS studies were performed on an LCMS-8040 tandem mass system (Shimadzu, Tokyo, Japan).
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