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Gdc0810

Manufactured by MedChemExpress
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GDC0810 is a selective inhibitor of the PI3K/mTOR pathway. It targets the PI3 kinase and mTOR enzymes, which are involved in cell growth, proliferation, and survival. GDC0810 can be used for research purposes to study the effects of PI3K/mTOR inhibition on various cellular processes and disease models.

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Lab products found in correlation

Actin a5441, by Merck Group (2 mentions) Vinculin 13901, by Cell Signaling Technology (2 mentions) Estradiol, by Merck Group (2 mentions) Bazedoxifene, by MedChemExpress (2 mentions) Tamoxifen treatment pellets, by Innovative Research (2 mentions) Fulvestrant, by MedChemExpress (2 mentions) Azd9496, by MedChemExpress (2 mentions) Er hc 20 or h184, by Santa Cruz Biotechnology (2 mentions)

2 protocols using gdc0810

1

Evaluating Endocrine Therapies in Breast Cancer

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Tamoxifen treatment pellets were purchased from Innovative Research of America. Fulvestrant, AZD9496, GDC0810, and bazedoxifene were purchased from MedChemExpress. Estradiol was purchased from Sigma-Aldrich, Inc. Antibodies used for immunoblot detection included the following: estrogen receptor (ER) - HC-20 or H184, Santa Cruz Biotechnology; actin - A5441, Sigma-Aldrich, Inc.; vinculin – 13901S, Cell signaling.
Wardell S.E., Yllanes A.P., Chao C.A., Bae Y., Andreano K.J., Desautels T.K., Heetderks K.A., Blitzer J.T., Norris J.D, & McDonnell D.P. (2019). Pharmacokinetic and pharmacodynamic analysis of fulvestrant in preclinical models of breast cancer to assess the importance of its estrogen receptor-α degrader activity in antitumor efficacy. Breast Cancer Research and Treatment, 179(1), 67-77.
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2

Estrogen Receptor Modulation Assay

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Tamoxifen treatment pellets were purchased from Innovative Research of America. Fulvestrant, AZD9496, GDC0810, and bazedoxifene were purchased from MedChemExpress. Estradiol was purchased from Sigma-Aldrich, Inc. Antibodies used for immunoblot detection included the following: estrogen receptor (ER)—HC-20 or H184, Santa Cruz Biotechnology; actin—A5441, Sigma-Aldrich, Inc.; vinculin—13901S, Cell Signaling.
Wardell S.E., Yllanes A.P., Chao C.A., Bae Y., Andreano K.J., Desautels T.K., Heetderks K.A., Blitzer J.T., Norris J.D, & McDonnell D.P. (2019). Pharmacokinetic and pharmacodynamic analysis of fulvestrant in preclinical models of breast cancer to assess the importance of its estrogen receptor-α degrader activity in antitumor efficacy. Breast Cancer Research and Treatment, 179(1), 67-77.
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