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Piximus 2 bone densitometer

Manufactured by GE Healthcare
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The PIXImus 2 is a bone densitometer manufactured by GE Healthcare. It is a device used to measure bone mineral density (BMD) in the body. The PIXImus 2 utilizes dual-energy X-ray absorptiometry (DXA) technology to assess bone health by scanning the body and providing quantitative data on bone density.

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Lab products found in correlation

μct40 scanner, by Scanco (1 mentions)

Spelling variants of this product

PIXImus (18 citations) PIXImus densitometer (11 citations) PIXImus II densitometer (9 citations)

6 protocols using piximus 2 bone densitometer

1

In Vivo Femoral and Spinal BMD Analysis

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BMD (g/cm2) quantifications were performed in anesthetized mice by Dual energy X-ray absorptiometry (DXA) using a PIXImus 2 bone densitometer (GE Medical Systems) and calibrated daily using a factory-supplied phantom. Anesthetized mice were placed on the imaging tray in a prostrate position. Total body DXA was performed and region of interest boxes placed to quantify anatomical sites including lumbar spine and femur. The left and right femurs were averaged for each mouse and the mean used for group calculations. Cross sectional BMD measurements at specific ages including 2, 3, 4, 6, 10, 15 and 21 months were repurposed from baseline BMDs from multiple studies previously conducted at these time points. The short-term in vitro reproducibility is 1.7% [22 (link)].
Li Y., Terauchi M., Vikulina T., Roser-Page S, & Weitzmann M.N. (2014). B Cell Production of Both OPG and RANKL is Significantly Increased in Aged Mice. The Open bone journal, 6, 8-17.
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2

Bone Mineral Density Quantification

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BMD (g/cm2) quantifications were performed in anesthetized mice by DEXA using a PIXImus 2 bone densitometer (GE Medical Systems). Total body DEXA was performed and region of interest boxes placed to quantify anatomical sites including lumbar spine, femur and tibia as previously described (25 (link)). The left and right femurs and left and right tibias were averaged for each mouse and the mean used for group calculations.
Roser-Page S., Vikulina T., Zayzafoon M, & Weitzmann M.N. (2014). CTLA4-Ig Induced T-Cell Anergy Promotes Wnt10b Production and Bone Formation. Arthritis & rheumatology (Hoboken, N.J.), 66(4), 990-999.
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3

In Vivo Femoral and Spinal BMD Analysis

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BMD (g/cm2) quantifications were performed in anesthetized mice by Dual energy X-ray absorptiometry (DXA) using a PIXImus 2 bone densitometer (GE Medical Systems) and calibrated daily using a factory-supplied phantom. Anesthetized mice were placed on the imaging tray in a prostrate position. Total body DXA was performed and region of interest boxes placed to quantify anatomical sites including lumbar spine and femur. The left and right femurs were averaged for each mouse and the mean used for group calculations. Cross sectional BMD measurements at specific ages including 2, 3, 4, 6, 10, 15 and 21 months were repurposed from baseline BMDs from multiple studies previously conducted at these time points. The short-term in vitro reproducibility is 1.7% [22 (link)].
Li Y., Terauchi M., Vikulina T., Roser-Page S, & Weitzmann M.N. (2014). B Cell Production of Both OPG and RANKL is Significantly Increased in Aged Mice. The Open bone journal, 6, 8-17.
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4

Femoral BMD Quantification in Mice

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BMD (g/cm2) quantifications were performed in anesthetized mice by dual energy X-ray absorptiometry (DXA) using a PIXImus 2 bone densitometer (GE Medical Systems). Region of interest boxes were placed to quantify the femur as previously described.20 (link) The left and right femurs were averaged for each mouse and the mean femoral BMD/mouse used for group calculations.
Weitzmann M.N., Ha S.W., Vikulina T., Roser-Page S., Lee J.K, & Beck GR J.r. (2015). Bioactive Silica Nanoparticles Reverse Age-Associated Bone Loss in Mice. Nanomedicine : nanotechnology, biology, and medicine, 11(4), 959-967.
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5

Quantifying Bone Mineral Density in Mice

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Bone mineral density (BMD) in (g/cm2) was quantified in anesthetized mice by Dual-energy X-ray absorptiometry (DEXA) using a PIXImus 2 bone densitometer (GE Medical Systems). Total body DEXA was performed and region of interest boxes placed to quantify anatomical sites including lumbar spine, femur and tibia as described.27 (link) Left and right femurs, and left and right tibias, were averaged for each mouse and means used for group calculations.
Roser-Page S., Vikulina T., Weiss D., Habib M.M., Beck GR J.r., Pacifici R., Lane T.F, & Weitzmann M.N. (2018). CTLA-4Ig (abatacept) balances bone anabolic-effects of T cells and Wnt-10b with anti-anabolic effects of osteoblastic sclerostin. Annals of the New York Academy of Sciences, 1415(1), 21-33.
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6

Femoral and Vertebral Bone Microarchitecture

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μCT was performed on the femur and third lumbar (L3) vertebrae (fixed in 70% ethanol) ex vivo to assess trabecular and cortical bone microarchitecture using a μCT40 scanner (Scanco Medical AG) that was calibrated weekly using a factory-supplied phantom. A total of 100 tomographic slices were taken from the femoral metaphysis and trabecular bone segmented from the cortical shell at a voxel size of 6 μm (70 kVp and 114 mA, and with 200 ms integration time). Cortical bone was quantified at the femoral middiaphysis from 99 tomographic slices. Projection images were reconstructed using the autocontour function for vertebral trabecular bone from approximately 350 tomographic slices. Representative samples based on mean BV/TV were reconstructed in 3D to generate visual representations. BMD analysis by DXA was performed on lumbar spine on a PIXImus2 bone densitometer (GE Medical Systems).
Roberts J.L., Yu M., Viggeswarapu M., Arnst J.L., Pacifici R, & Beck GR J.r. (2023). Dietary phosphorus consumption alters T cell populations, cytokine production, and bone volume in mice. JCI Insight, 8(10), e154729.
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