The [99mTc]Tc-TG, in a dose of 729 ± 102 MBq, was injected as an intravenous bolus. A Siemens Symbia Intevo Bold scanner was used for imaging. A high-resolution low-energy collimator was used to images acquisition. Anterior and posterior whole-body planar imaging (at a scan speed of 12 cm/min, 1024 × 256 pixel matrix) was carried out in patients 1–10 at 2, 4, 6 and 24 h after injection. All 12 patients received SPECT/CT scans (SPECT: 60 projections, 20 s each, 256 × 256 pixel matrix; CT: 130 kV, effective 36 mAs) at 2 h and only SPECT scans (60 projections, 20 s each, 256 × 256 pixel matrix) 4 and 6 h after injection. For SPECT reconstruction, the xSPECT (Siemens) protocol based on the ordered subset conjugate gradient (OSCG) method (24 iterations, 2 subsets) was used. The 3D Gaussian FWHM 10 mm filter (Soft Tissue) was used. For processing of obtained images, the proprietary software package syngo.via (Siemens) was used.
Vital signs were monitored before, during and after imaging. Parameters of blood biochemistry were analyzed before injections of [99mTc]Tc-TG and 24, 48 h and 7 days after injections.
Vital signs were monitored before, during and after imaging. Parameters of blood biochemistry were analyzed before injections of [99mTc]Tc-TG and 24, 48 h and 7 days after injections.