Adult male spontaneously hypertensive rats

Manufactured by Charles River Laboratories

Adult male spontaneously hypertensive rats are a laboratory animal model used for research purposes. They exhibit high blood pressure that develops naturally without intervention. These animals can be used to study the mechanisms and effects of hypertension, as well as potential treatments or interventions.

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Lab products found in correlation

B27 without retinoic acid, by Thermo Fisher Scientific (1 mentions) Cytochrome c oxidase kit, by Merck Group (1 mentions) Cell titer glow reagent, by Promega (1 mentions) Recombinant human fgf 2, by Thermo Fisher Scientific (1 mentions) Neurobasal medium, by Thermo Fisher Scientific (1 mentions) Accutase, by Merck Group (1 mentions) Heparin, by Merck Group (1 mentions) Glutamine, by Merck Group (1 mentions) Antibiotic mixture, by Thermo Fisher Scientific (1 mentions)

Spelling variants of this product

Adult male rats (5 citations) Male spontaneously hypertensive rats (SHR) (4 citations)

2 protocols using adult male spontaneously hypertensive rats

Isolation and Culture of Rat Neurons

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Adult male spontaneously hypertensive rats (250-350g) were purchased from Charles River Laboratories. Neurobasal medium, B27 (without retinoic acid), recombinant human FGF-2 and antibiotic mixture were purchased from Invitrogen (Carlsbad, CA, USA). Other reagents were purchased from the following suppliers: CellTiter-Glow reagent (Promega Inc. Madison, WI, USA); Cytochrome C Oxidase kit, Accutase, Heparin and Glutamine were from Sigma chemical company (St. Louis MO, USA).

Kalluri H.S, & Dempsey R.J. (2014). D609 mediated inhibition of ATP synthesis in neural progenitor cells. Neuroreport, 25(10), 777-781.

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Spontaneously Hypertensive Rat Study

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Adult male spontaneously hypertensive rats between 12 and 14 weeks of age and weighing 290–310 g (obtained from Charles River) were used for this study. Animals were housed under standard conditions (21°–23°C, 12-hour light-dark cycle) with unlimited access to standard food and water. All animal experiments were approved by the Vanderbilt University Institutional Animal Care and Use Committee and performed according to the National Research Council’s Guide for the Care and Use of Laboratory Animals.

Khan I.S., Odom M., Ehtesham M., Colvin D., Quarles C.C., McLaughlin B, & Singer R.J. (2015). Intraarterial administration of norcantharidin attenuates ischemic stroke damage in rodents when given at the time of reperfusion: novel uses of endovascular capabilities. Journal of neurosurgery, 125(1), 152-159.

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