Smoke generator

Manufactured by Buxco Electronics

Sourced in United States

The Smoke Generator is a device designed to produce controllable amounts of smoke for testing and demonstration purposes. It operates by heating a specialized fluid to generate a dense, visible smoke output. The core function of the Smoke Generator is to provide a consistent, reliable source of smoke for various applications.

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Lab products found in correlation

Sprague dawley rats, by Spf Biotechnology (1 mentions) Lipopolysaccharides (lps), by Merck Group (1 mentions)

4 protocols using smoke generator

Rat Model for Chronic Obstructive Pulmonary Disease

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Sixty Sprague Dawley (SD) rats (200 ± 20 g) were purchased from SPF Biotechnology Co., Ltd. (Shandong, China). The rats were housed in the animal facilities at 25 ± 2℃, 50 ± 10% relative humidity, and a 12 h light/dark cycle for 1 week prior to the experiment. They had ad libitum access to standard food and water.
The COPD rat model was prepared as described previously.14 (link),15 (link) Briefly, the SD rats were exposed to tobacco smoke (Hongqi Canal® Filter cigarettes, Henan Tobacco Industry, Zhengzhou, China; each cigarette contained 10 mg tar oil, 1.0 mg nicotine and 12 mg carbon monoxide) from a smoke generator (BUXCO, Wilmington, NC, USA) 30 min per exposure (concentration: 3000± 500 ppm), twice a day, with three hour smoke-free intervals, from week one through week eight. In addition, the LPS (1 mg/kg) purchased from Sigma-Aldrich Co., Ltd. was slowly dropped into the nasal cavities of rats, twice per week for the first eight weeks. The control rats were administered 0.9% saline (0.2 mL).

Mao J., Li Y., Bian Q., Xuan Y., Li J., Wang Z., Feng S., Liu X., Tian Y, & Li S. (2022). The Bufei Jianpi Formula Improves Mucosal Immune Function by Remodeling Gut Microbiota Through the SCFAs/GPR43/NLRP3 Pathway in Chronic Obstructive Pulmonary Disease Rats. International Journal of Chronic Obstructive Pulmonary Disease, 17, 1285-1298.

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Lung Cancer Mouse Model Protocol

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The animal studies were approved by the Institutional Review Board of our hospital with protocols approved by the Animal Ethics Committee of our hospital. The A/J mice (5- to 6-week old, female) were obtained from the Jackson Laboratory (Bar Harbor, Maine, USA). OT-1 transgenic mice were a generous gift from Professor Bo Huang of the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences. The A/J mice received gavage administration of NNK at a dose of 50 mg/kg twice a week for 5 weeks, the IDO1 inhibitor 1-MT at 50 mg/kg, or the α7nAChR inhibitor α-BGT at 5 mg/kg, and control mice were treated with saline. In other experiments, the A/J mice inside in a perspex box were exposed to cigarette smoke produced by a smoke generator (Buxco, NC, USA), at a frequency of 12 cigarettes per day 5 days per week for 24 weeks. Control mice were exposed to normal air.

Liang F., Wang G.Z., Wang Y., Yang Y.N., Wen Z.S., Chen D.N., Fang W.F., Zhang B., Yang L., Zhang C., Han S.C., Yang F.Y., Wang D., Liang L.J., Wang Z., Zhao Y., Wang C.L., Zhang L, & Zhou G.B. (2022). Tobacco carcinogen induces tryptophan metabolism and immune suppression via induction of indoleamine 2,3-dioxygenase 1. Signal Transduction and Targeted Therapy, 7, 311.

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COPD Rat Model Generation Protocol

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Forty-eight rats were randomized into control, model (COPD), Bufei Jianpi, and aminophylline groups. Six male and 6 female rats were in each group. The COPD rat model was generated by using repeated cigarette smoke inhalation and bacterial infection, while control animals received ventilation with filtered air. Rats were exposed to cigarette-smoke (concentration: 3000 ± 500 ppm) generated from a smoke generator (Buxco, Wilmington, NC, USA) for 30 min, twice per day, at 3-hour intervals. Klebsiella pneumonia solution (0.1 mL) was slowly dropped into both nostrils of the rats in an alternating fashion, every 5 days for the first 8 weeks [25 (link)].

Mao J., Li Y., Li S., Li J., Tian Y., Feng S., Liu X., Bian Q., Li J., Hu Y., Zhang L, & Ji H. (2019). Bufei Jianpi Granules Reduce Quadriceps Muscular Cell Apoptosis by Improving Mitochondrial Function in Rats with Chronic Obstructive Pulmonary Disease. Evidence-based Complementary and Alternative Medicine : eCAM, 2019, 1216305.

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Rat Model of AECOPD Exacerbation

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Twenty-five male Sprague-Dawley rats were randomly divided into control, COPD, AECOPD, and Western medicine (moxifloxacin hydrochloride tablets + salbutamol sulfate tablets, MXF/STL) and integrated with Chinese and Western medicine (Tong Sai granules + moxifloxacin hydrochloride tablets + salbutamol sulfate tablets + Bu Fei Yi Shen granules + salbutamol sulfate tablets, TMS/FS) groups using the RAND function in EXCEL. With the exception of the control group, the other groups of rats received an LPS drip solution (1 mg/mL, 0.05 mg/100 g body mass) in the nasal cavity, twice per week, as well as cigarette smoke exposure generated from a smoke generator (BUXCO, Wilmington, NC, USA) with concentration of 3000 ± 500 ppm, 30 min per time, twice per day, at interval of ≥3 hour, from week 1 to week 8. Following that, LPS solution (1 mg/mL, 0.2 mg/100 g body mass) was administered to the AECOPD, MXF/STL, and TMS/FS rats by means of a nasal drip, to simulate AECOPD.

Li X., Li Y., Mao J., Bian Q., Xuan Y., Shen T, & Li S. (2021). Combination of Chinese and Western Medicine Optimizes the Intestinal Microbiota of Exacerbated Chronic Obstructive Pulmonary Disease in Rats. Evidence-based Complementary and Alternative Medicine : eCAM, 2021, 9975407.

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