Gne684

Manufactured by Genentech

Sourced in United States

GNE684 is a laboratory instrument designed for use in biological research and analysis. It is capable of performing a variety of tasks, including sample preparation, separation, and detection. The core function of GNE684 is to facilitate the processing and analysis of biological samples, such as proteins, nucleic acids, or cells. The specific details and intended use of this product are not provided in this factual and unbiased description.

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Lab products found in correlation

Il 1b af 401 na, by R&D Systems (1 mentions) Ciap1 2, by R&D Systems (1 mentions) Emricasan, by Selleck Chemicals (1 mentions) Tumor necrosis factor (tnf), by Genentech (1 mentions) Caspase 1, by Genentech (1 mentions) Lipopolysaccharides (lps), by InvivoGen (1 mentions) Nec 1a, by Genentech (1 mentions) Mlkl mabc604, by Merck Group (1 mentions)

3 protocols using gne684

Synthesis of Genentech's GNE684 Compound

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GNE684 was synthesized at Genentech (South San Francisco, CA, USA).7

Webster J.D., Kwon Y.C., Park S., Zhang H., Corr N., Ljumanovic N., Adedeji A.O., Varfolomeev E., Goncharov T., Preston J., Santagostino S.F., Patel S., Xu M., Maher J., McKenzie B.S, & Vucic D. (2020). RIP1 kinase activity is critical for skin inflammation but not for viral propagation. Journal of Leukocyte Biology, 107(6), 941-952.

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Comprehensive Cell Death Pathway Analysis

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Human recombinant TNF, BV6, GNE684, and GSK583 were all synthesized at Genentech. Emricasan was purchased from Selleck Chemicals (S7775), zVAD from ABclonal and LPS from InvivoGen (tlrl-3peLPS). The primary antibodies used were directed against: RIP1 (610459, BD Biosciences), pRIP1 S166 (#31122, Cell Signaling Technology (CST)), RIP3 (#15828, CST), pRIP3 (#91702, CST), MLKL (#MABc604, Millipore), pMLKL (#37333, CST), FADD (#05-486, Millipore), RIP2 (#22763, Santa Cruz), XIAP (M044-3, MBL, 66800-1-Ig, Proteintech), c-IAP2 (Genentech), c-IAP1/2 (#3400, R&D), caspase-1(Genentech), caspase-3 (#9661, 9662, CST), caspase-7(#9491, CST), caspase-8 (#8592, 9429, 4927, CST), caspase-11(#14340, CST), GSDMD (#50928, CST), IL-1b (AF-401-NA, R&D), JNK(#9252, CST), pJNK (#4668, CST), p65(#8242, CST), p-p65(#3033, CST), IkBa (#9242, CST), p-IkBa (#2859, CST), p38 (#9212, CST), p-p38 (#9211, CST), ERK (#4695, CST), p-ERK (#4370, CST), actin (A3853, Sigma), GapDH (#2118, CST), HSP90 (#4877, CST).

Witt A., Goncharov T., Lee Y.M., Kist M., Dohse M., Eastham J., Dugger D., Newton K., Webster J.D, & Vucic D. (2023). XIAP deletion sensitizes mice to TNF-induced and RIP1-mediated death. Cell Death & Disease, 14(4), 262.

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Investigating Necroptosis Signaling Pathways

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Human recombinant TNF, Nec-1a, BV6, GNE684, and GSK547 were all synthesized at Genentech. The primary antibodies used were directed against: RIP1 (610459), pJNK (562480) (BD Biosciences); IκBα (9242), HSP90 (4874), A20 (5630), caspase-8 (9746), human pRIP1 S166 (65746), and RIP3 (13526) (Cell Signaling Technology); mouse pMLKL S345 (ab196436) and human c-IAP2 (ab32059) (Abcam); MLKL (MABC604) (Millipore); mouse c-IAP2 and RIP3 (Genentech).

Patel S., Webster J.D., Varfolomeev E., Kwon Y.C., Cheng J.H., Zhang J., Dugger D.L., Wickliffe K.E., Maltzman A., Sujatha-Bhaskar S., Bir Kohli P., Ramaswamy S., Deshmukh G., Liederer B.M., Fong R., Hamilton G., Lupardus P., Caplazi P., Lee W.P., van Lookeren Campagne M., Johnson A., McKenzie B.S., Junttila M.R., Newton K, & Vucic D. (2019). RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases. Cell Death and Differentiation, 27(1), 161-175.

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