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Polyvinyl pyrrolidone kollidon 30

Manufactured by BASF
Sourced in Germany

Polyvinyl pyrrolidone (Kollidon® 30) is a versatile polymer used in various pharmaceutical and industrial applications. It is a water-soluble, synthetic polymer with a chemical structure consisting of repeating units of N-vinyl-2-pyrrolidone. Kollidon® 30 has a molecular weight range of 44,000 to 54,000 and is commonly used as a binder, disintegrant, and solubilizer in pharmaceutical formulations.

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4 protocols using polyvinyl pyrrolidone kollidon 30

1

Formulation and Characterization of Eudragit-Based Polymeric Films

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TT was a gift from Aurobindo Pharmaceuticals (India). Eudragit E 100, RS100, RL100, RSPO and RLPO were gift s from Evonik Röhm GmbH, Germany. EUDRAGIT ® polymers are copolymers derived from esters of acrylic and methacrylic acid whose physicochemical properties are determined by functional groups. In these studies, Eudragit E 100 is a cationic polymer with dimethylaminoethyl methacrylate as a functional group. Other Eudragit grades such as RS100, RL100, RSPO and RLPO are ethyl acrylate, methyl methacrylate copolymers with trimethyl-ammonioethylmethacrylate as diff erent ratios of the functional group. Polyvinyl pyrrolidone (Kollidon ® 30) was procured from the BASF Chemical Company, Germany. Dibutyl phthalate (DBP) was purchased from Qualigens Fine Chemicals, India. Triethyl citrate (TEC) was purchased from Merck Chemicals, Germany. Dibutyl Sebacate (DBS) was purchased from Sigma-Aldrich Chemie GmbH, Germany. All other chemicals used in the study were of analytical grade and were used as received.
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2

PLGA Nanoparticle Synthesis and Characterization

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PLGA Purasorb® PDLG 7502 was obtained from Corbion Purac Biomaterials, Netherlands. Dichloromethane, methanol, trifluoroacetic acid, dexamethasone, polyvinyl alcohol, Tween 80, and sodium azide were purchased from Sigma-Aldrich, Saint-Quentin-Fallavier, France. Acetonitrile was purchased from Fisher Scientific, Loughborough, UK. Coumarine-6 was purchased from Acros Organic, Morris Plains, NJ, USA. Polyvinyl pyrrolidone Kollidon®30 and Kollidon®F90 grades were purchased from BASF, Heidelberg, Germany. polyvinyl alcohol, gelatine, phosphate buffer saline tablets (pH 7.4), Acetonitrile, and 10% neutral-buffered formalin were purchased from Sigma Aldrich, Burlington, MA, USA. Methylprednisolone was purchased from Cambridge Bioscience, Cambridge, UK. SlowFade™ gold antifade mountant and optimal cutting temperature compound (OCT Cellpath) were purchased from ThermoFisher, Oxford, UK.
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3

Formulation of D-Mannitol Beads for Drug Delivery

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D-mannitol beads (355–500 micron, NONPAREIL®-108, Lot no.140204) were purchased from Freund Corporation (Shinjuku-ku, Japan). Bovine serum albumin (A9085-25G, Lot no. SLBM9836V, purity >96% by agarose gel electrophoresis) and HPLC grade water were obtained from Sigma Aldrich (St. Louis, MO). Polyvinylpyrrolidone (Kollidon® 30, Lot no. G41216PT0) was a gift from BASF (Tarrytown, NY). EUDRAGIT® FS 30 D (Poly(methyl acrylate-co-methyl methacrylate-co-methacrylic acid) 7:3:1, Lot no. B150165002) and PlasACRYL® T20 (Lot no. PT150402) were a gift from Evonik (Parsippany, USA).
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4

Solubility Enhancement of FNB

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FNB was obtained from Kaifeng Pharmaceutical Factory (Henan, China). Indomethacin was used as the internal standard and purchased from Wuhan DKY Technology Co., Ltd (Wuhan, China). Transcutol HP was provided by Gattefosse (Saint-Priest Cedex, France). Cremophor RH40, polyvinylpyrrolidone Kollidon 30 (PVP K30), polyvinylpyrrolidone Kollidon 90 (PVP K90), vinylprrolidone–vinylacetate copolymer Kollidon VA64 (PVP VA64), and Soluplus were kindly donated by BASF (Ludwigshafen, Germany). Hydroxypropyl methyl cellulose E3 (HPMC E3), HPMC E5, and HPMC E15 were supplied by Dow Chemical Company (Midland, TX, USA). EO was purchased from Sinopharm Chemical Reagent Co., Ltd (Shanghai, China). All other chemicals and solvents were of reagent grade and used without further purification.
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