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Gu15 3yl

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The GU15 3YL is a compact and versatile laboratory equipment product. Its core function is to provide precise temperature and humidity control for various applications within a laboratory setting. The GU15 3YL is designed to maintain consistent environmental conditions to support experimental procedures and sample preservation.

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Lab products found in correlation

Sarrp irradiator, by Xstrahl (1 mentions) Sarrp, by Xstrahl (1 mentions)

4 protocols using gu15 3yl

1

SMSM-167 and Radiotherapy for U87-Luc Tumors

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Example 23

Study Aim

To evaluate efficacy of SMSMs in Subcutaneous U87-Luc Brain Tumor Model in combination with radiotherapy

Experimental Design

Subcutaneous U87-Luc Brain Tumor Model in Ncr Nude Mice: tumor inoculation on Day 0; compound treatment initiation at 100 mm3 (Day 0), twice daily by oral gavage; radiotherapy treatment on Day 3. The radiotherapy treatment (10 Gy) was conducted using Image Guided Small Animal Radiation Research Platform (SARRP) irradiator (Xstrahl Limited, GU15 3YL).

Experimental Groups

The experimental groups used in this study are shown in the table below. Results are shown in FIGS. 24A and 24B.

Treatment 1
Group# MiceTreatment 1ScheduleTreatment 2Treatment 2 Schedule
Group 15NoneNAVehicleBID from Day 0 for the
duration of the study
Group 25NoneNASMSM-167, BID from Day 0 for the
5 mg/kgduration of the study
Group 3510 GyDay 3VehicleBID from Day 0 for the
duration of the study
Group 4510 GyDay 3SMSM-167,BID from Day 0 for the
5 mg/kgduration of the study

The examples and embodiments described herein are for illustrative purposes only and various modifications or changes suggested to persons skilled in the art are to be included within the spirit and purview of this application and scope of the appended claims.

US11008572B2. Methods and compositions for modulating splicing (2021-05-18). SKYHAWK THERAPEUTICS, INC. [US]. Inventors: Michael Luzzio [US], Kathleen McCarthy [US], William Haney [US].
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2

Evaluating SMSM Efficacy with Radiotherapy in Subcutaneous Brain Tumor Model

Check if the same lab product or an alternative is used in the 5 most similar protocols

Example 23

Study Aim

To evaluate efficacy of SMSMs in Subcutaneous U87-Luc Brain Tumor Model in combination with radiotherapy

Experimental Design

Subcutaneous U87-Luc Brain Tumor Model in NcrNude Mice: tumor inoculation on Day 0; compound treatment initiation at 100 mm3 (Day 0), twice daily by oral gavage; radiotherapy treatment on Day 3. The radiotherapy treatment (10 Gy) was conducted using Image Guided Small Animal Radiation Research Platform (SARRP) irradiator (Xstrahl Limited, GU15 3YL).

Experimental Groups

The experimental groups used in this study are shown in the table below. Results are shown in FIGS. 24A and 24B.

#Treatment 1Treatment 2
GroupMiceTreatment 1ScheduleTreatment 2Schedule
Group 15NoneNAVehicleBID from Day 0 for the
duration of the study
Group 25NoneNASMSM-167, 5 mg/kgBID from Day 0 for the
duration of the study
Group 3510 GyDay 3VehicleBID from Day 0 for the
duration of the study
Group 4510 GyDay 3SMSM-167, 5 mg/kgBID from Day 0 for the
duration of the study

The examples and embodiments described herein are for illustrative purposes only and various modifications or changes suggested to persons skilled in the art are to be included within the spirit and purview of this application and scope of the appended claims.

US11021708B2. Methods and compositions for modulating splicing (2021-06-01). SKYHAWK THERAPEUTICS, INC. [US]. Inventors: Michael Luzzio [US], Kathleen McCarthy [US], William Haney [US].
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3

Efficacy of SMSMs in Subcutaneous U87-Luc Brain Tumor Model

Check if the same lab product or an alternative is used in the 5 most similar protocols

Example 23

Study Aim

To evaluate efficacy of SMSMs in Subcutaneous U87-Luc Brain Tumor Model in combination with radiotherapy

Experimental Design

Subcutaneous U87-Luc Brain Tumor Model in NcrNude Mice: tumor inoculation on Day 0; compound treatment initiation at 100 mm3 (Day 0), twice daily by oral gavage; radiotherapy treatment on Day 3. The radiotherapy treatment (10 Gy) was conducted using Image Guided Small Animal Radiation Research Platform (SARRP) irradiator (Xstrahl Limited, GU15 3YL).

Experimental Groups

The experimental groups used in this study are shown in the table below. Results are shown in FIGS. 24A and 24B.

#Treatment 1Treatment 2
GroupMiceTreatment 1ScheduleTreatment 2Schedule
Group 15NoneNAVehicleBID from Day 0 for the
duration of the study
Group 25NoneNASMSM-167, 5 mg/kgBID from Day 0 for the
duration of the study
Group 3510 GyDay 3VehicleBID from Day 0 for the
duration of the study
Group 4510 GyDay 3SMSM-167, 5 mg/kgBID from Day 0 for the
duration of the study

The examples and embodiments described herein are for illustrative purposes only and various modifications or changes suggested to persons skilled in the art are to be included within the spirit and purview of this application and scope of the appended claims.

US11162101B2. Methods and compositions for modulating splicing (2021-11-02). SKYHAWK THERAPEUTICS, INC. [US]. Inventors: Michael Luzzio [US], Kathleen McCarthy [US], William Haney [US].
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4

Evaluating SMSM Efficacy in U87-Luc Brain Tumor Model

Check if the same lab product or an alternative is used in the 5 most similar protocols

Example 23

Study Aim

To evaluate efficacy of SMSMs in Subcutaneous U87-Luc Brain Tumor Model in combination with radiotherapy

Experimental Design

Subcutaneous U87-Luc Brain Tumor Model in NcrNude Mice: tumor inoculation on Day 0; compound treatment initiation at 100 mm3 (Day 0), twice daily by oral gavage; radiotherapy treatment on Day 3. The radiotherapytreatment (10 Gy) was conducted using Image Guided Small Animal Radiation Research Platform (SARRP) irradiator (Xstrahl Limited, GU15 3YL).

Experimental Groups

The experimental groups used in this study are shown in the table below. Results are shown in FIGS. 24A and 24B.

Treat-Treat-Treat-
#mentment 1ment
GroupMice1Schedule2Treatment 2 Schedule
Group 5NoneNAVehicleBID from Day 0 for the
1duration of the study
Group 5NoneNASMSM-167, BID from Day 0 for the
25 mg/kgduration of the study
Group 510 GyDay 3VehicleBID from Day 0 for the
3duration of the study
Group 510 GyDay 3SMSM-167, BID from Day 0 for the
45 mg/kgduration of the study

The examples and embodiments described herein are for illustrative purposes only and various modifications or changes suggested to persons skilled in the art are to be included within the spirit and purview of this application and scope of the appended claims.

US11434489B1. Methods and compositions for modulating splicing (2022-09-06). SKYHAWK THERAPEUTICS, INC. [US]. Inventors: Michael Luzzio [US], Kathleen McCarthy [US], William Haney [US].
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