drug release experiments, five sets of uncoated and 0.1, 1.0, 5.0,
and 10 mg/mL drug-coated fibers, each about 70 cm length, were accurately
weighed and immersed in a screw-top glass bottle containing 10 mL
of the phosphate buffer saline (PBS) solution (pH = 7.40 ± 0.2).
Then, all bottles were immediately placed in an incubator that was
thermostatically controlled at 37.0 ± 1.0 °C. At a certain
period of time, the fiber samples were filtered out and dried under
vacuum at room temperature to constant weight. After that, drug release
behavior of sutures during in vitro degradation was
measured.
The adsorption intensity of the LVFX drug was measured
by a UV spectrophotometer (PerkinElmer LAMBDA 850+ UV/vis spectrophotometer)
at 298 nm using 0.1 M HCl solution as a blank control. The calibration
curve of the LVFX drug (see Supporting Information
(mg/mL) and absorbance (AU); therefore, the amount of LVFX in the
release medium can be determined by this standard curve and the cumulative
release rate was then calculated according to