Tetrahydrofuran thf

Manufactured by Fujifilm

Sourced in Japan

Tetrahydrofuran (THF) is a colorless, volatile, and flammable organic compound. It is a versatile solvent used in various industrial applications, such as the synthesis of polymers, pharmaceuticals, and other chemicals. THF has a low boiling point and is widely used as a reaction medium in chemical processes.

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Lab products found in correlation

Dichloromethane, by Fujifilm (3 mentions) Methanol, by Fujifilm (3 mentions) Ethanol, by Fujifilm (3 mentions) Diisopropyl ether, by Fujifilm (2 mentions) N n dimethylformamide (dmf), by Fujifilm (2 mentions) Ethyl acetate, by Fujifilm (2 mentions) Hydrochloric acid (hcl), by Fujifilm (2 mentions) Chloroform, by Fujifilm (2 mentions) Acetone, by Fujifilm (2 mentions) Acetonitrile, by Fujifilm (2 mentions) Alcl3, by Fujifilm (1 mentions) Sinapinic acid, by Merck Group (1 mentions) Triphenylphosphine, by Merck Group (1 mentions) Methyl ricinoleate, by Tokyo Chemical Industry (1 mentions) Dichloromethane ch2cl2, by Kanto Chemical (1 mentions) N n diisopropylcarbodiimide dic, by Fujifilm (1 mentions) Chloroform d1, by Kanto Chemical (1 mentions) Ferulic acid, by Merck Group (1 mentions) P coumaric acid, by Merck Group (1 mentions) Acetic anhydride, by Tokyo Chemical Industry (1 mentions)

Spelling variants of this product

Tetrahydrofuran (27 citations) Anhydrous tetrahydrofuran (THF) (2 citations)

20 protocols using tetrahydrofuran thf

Synthesis and Characterization of Magnesium Salt

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Example 15

(1) Synthesis of a Magnesium Salt

Under argon gas atmosphere, diphenylsilanediol (8.65 g, 40 mmol) (Tokyo Chemical Industry Co., Ltd.) was dissolved in tetrahydrofuran (THF) (20 mL) (Wako Pure Chemical Industries, Ltd.), and then a THF solution of phenylmagnesium chloride (PhMgCl) (40 mL, 80 mmol) (Tokyo Chemical Industry Co., Ltd., 2 M) was added dropwise, and the solution was stirred for 1 hour. After that, powder generated by concentration and drying of the solution, was washed with diisopropyl ether (50 mL) (Wako Pure Chemical Industries, Ltd.). The powder was filtered off and dried to obtain diphenylsilanedioxy bis(magnesium chloride), (Ph₂Si(OMgCl)₂).

[Figure (not displayed)]

Measurement result of ¹H-NMR is shown below.

¹H-NMR (400 MHz, CDCl₃) δ (ppm): 6.90-8.00 (m, 10H)

(2) Preparation of the Electrolytic Solution

Under argon gas atmosphere, into diphenylsilanedioxy bis(magnesium chloride) (Ph₂Si(OMgCl)₂) (0.83 g, 2.5 mmol), THF (20 mL) (Wako Pure Chemical Industries, Ltd.) was mixed. The mixture was heated to 50° C., and then aluminum chloride (AlCl₃) (0.67 g, 5 mmol) (Wako Pure Chemical Industries, Ltd.) was added to the mixture. After maintaining the resulting mixture at 50° C. for 10 minutes, it was cooled to obtain the electrolytic solution 14, “a solution of diphenylsilanedioxy bis(magnesium chloride)-aluminum chloride/THF”.

US10367231B2. Magnesium-containing electrolytic solution (2019-07-30). FUJIFILM Wako Pure Chemical Corporation [JP]. Inventors: Kazuhiko Sato [JP], Takahiro Kiyosu [JP], Hironori Mizuta [JP], Goro Mori [JP], Kuniaki Okamoto [JP].

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Synthesis and Characterization of Ferulic Acid Esters

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Ferulic acid (99%) and triphenyl phosphine (99%) were purchased from Sigma-Aldrich Japan Co., Ltd. p-Coumaric acid (>98.0%), sinapinic acid (>98.0%), oxalyl chloride (>98.0%), and diisopropyl azodicarboxylate (40% in toluene, ca. 1.9 mol L⁻¹) were purchased from Tokyo Chemical Industry Co., Ltd. Methyl ricinoleate (>97.0%), acetic anhydride (>97.0%), N,N-dimethylaminopyridine (DMAP) (>99.0%), N,N′-diisopropylcarbodiimide (DIC) (>99.0%), pyridine (>99.5%, dehydrated), N,N-dimethylformamide (DMF) (>99.5%, dehydrated), sodium sulphate (Na₂SO₄) (>99.0%), and tetrahydrofuran (THF) (>99.5%, with stabilizer, for gel permeation chromatography (GPC) grade) were purchased from FUJIFILM Wako Pure Chemical Corporation. p-Toluenesulfonic acid monohydrate (>99.0%) and lithium hydroxide monohydrate (>99.0%) were purchased from KISHIDA CHEMICAL Co., Ltd. Toluene (>99.5%, dehydrated), dichloromethane (CH₂Cl₂) (>99.5%, dehydrated), and THF (>99.5%, dehydrated stabilizer free) were purchased from Kanto Chemical and purified on a Glass Contour Solvent Purification System (NIKKO HANSEN & Co., Ltd, Japan). Chloroform-d₁ (99.8 atom % D with 0.03 vol% tetramethylsilane) was purchased from Kanto Chemical. These chemicals were used without further purification unless otherwise noted. 4-(Dimethylamino)pyridinium p-toluenesulfonate (DPTS) was synthesised according to the literature.^{43 (link)}

Yamamoto A., Nemoto K., Yoshida M., Tominaga Y., Imai Y., Ata S., Takenaka Y., Abe H, & Sato K. (2020). Improving thermal and mechanical properties of biomass-based polymers using structurally ordered polyesters from ricinoleic acid and 4-hydroxycinnamic acids. RSC Advances, 10(60), 36562-36570.

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Synthesis and Purification of Organometallic Precursor

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Dichloromethane, N,N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), ethyl acetate, hexane, methanol, tetrahydrofuran (THF), lithium bromide (LiBr), and chloro(1,5-cyclooctadiene)(η⁵-pentamethylcyclopentadienyl)ruthenium(II) (Cp*RuCl(COD)) were purchased from FUJIFILM Wako Pure Chemical Corp. (Osaka, Japan). A solution of tetrabutylammonium fluoride (TBAF) in THF (1 M) was purchased from Tokyo Chemical Industry Co., Ltd. (Tokyo, Japan). Copper(I) bromide (CuBr), sodium chloride (NaCl), sodium sulfate (Na₂SO₄), and tetrasodium ethylenediaminetetraacetate (EDTA·4Na) were purchased from Nacalai Tesque, Inc. (Kyoto, Japan). Pentamethylcyclopentadienylbis(triphenylphosphine)ruthenium(II) chloride (Cp*RuCl(PPh₃)₂) was purchased from Sigma–Aldrich (St. Louis, MO, USA). Merck precoated TLC plates (Silica gel 60 F254) were used for thin layer chromatography (TLC) analysis in this work. Silica gel 60 (Nacalai Tesque, spherical, neutrality) was used for column chromatography to purify the products. THF and DMF were dried with flame-dried molecular sieves 4A. Other reagents were used without further purification. tBuAH and t-butyl 6-(t-butyldimethylsilyl)-4-hydroxy-5-hexynoate (1) were prepared according to the procedure reported previously [26 (link)].

Taguchi R., Nakahata M., Kamon Y, & Hashidzume A. (2023). Synthesis of Dense 1,2,3-Triazole Oligomers Consisting Preferentially of 1,5-Disubstituted Units via Ruthenium(II)-Catalyzed Azide–Alkyne Cycloaddition. Polymers, 15(9), 2199.

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Synthesis of Metal-Doped Carbon Nitride Frameworks

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Each CTF was prepared using essentially the same method described in our previous publications.7 Briefly, 2,6-dicyanopyridine (64.5 mg, Koei Kagaku) and Ketjen Black EC600JD (64.5 mg, Lion Corp.) were mixed with ZnCl₂ (6.82 g, Wako) in a glass vacuum tube and then heated to 400 °C at 3.3 °C min^–1 and held at that temperature for 40 h. The resulting powder was washed with deionized water, tetrahydrofuran (THF, Wako), HCl (1 M, Wako) and aqueous ammonia (1 M, Wako). The obtained CTF was dispersed in a 10 mM aqueous solution of MCl₂ (M = Co, Ni or Cu) and stirred at 80 °C for 3 h. Subsequently, the product was collected by centrifugation and thoroughly washed with deionized water to remove any unbound metal salt, followed by drying at 60 °C in a vacuum oven for 1 day.

Su P., Iwase K., Harada T., Kamiya K, & Nakanishi S. (2018). Covalent triazine framework modified with coordinatively-unsaturated Co or Ni atoms for CO2 electrochemical reduction †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc00604k. Chemical Science, 9(16), 3941-3947.

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Synthesis and Characterization of EVA Copolymers

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Poly(ethylene‐co‐vinyl acetate) copolymers (abbreviated as EVA) and {(2E)‐2‐methyl‐3‐[4‐(2‐methyl‐2‐propanyl)phenyl]‐2‐propen‐1‐ylidene}malononitrile (known as DCTB) were purchased from Sigma Aldrich (St. Louis, MO, USA). Chloroform (CHCl₃) used in SEC and tetrahydrofuran (THF) were from Wako Pure Chemical Industries (Osaka, Japan). The poly(methyl methacrylate) standard (M_p = 1310 g mol^–1) used for the external calibration of the MALDI mass spectra was purchased from Polymer Laboratories (Church Stretton, UK).

Fouquet T., Nakamura S, & Sato H. (2016). MALDI SpiralTOF high‐resolution mass spectrometry and Kendrick mass defect analysis applied to the characterization of poly(ethylene‐co‐vinyl acetate) copolymers. Rapid Communications in Mass Spectrometry, 30(7), 973-981.

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Polymeric Nanoparticles for Drug Delivery

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PLGA (50:50 ratio, Mw = 24000–38000
Da) and PEG-PLGA (average Mn_PEG = 2000
Da, average Mn_PLGA = 11500 Da) were obtained
from Sigma-Aldrich (St. Louis, MO, USA). PTX, COX, and DOX were purchased
from Tokyo Chemical Industry Ltd. (Tokyo, Japan). Acetonitrile (ACN),
dimethyl sulfoxide (DMSO), dimethylformamide (DMF), and tetrahydrofuran
(THF) were purchased from FUJIFILM Wako Pure Chemical Corporation
(Osaka, Japan).

Bao Y., Maeki M., Ishida A., Tani H, & Tokeshi M. (2022). Effect of Organic Solvents on a Production of PLGA-Based Drug-Loaded Nanoparticles Using a Microfluidic Device. ACS Omega, 7(37), 33079-33086.

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Magnesium Alloy Cytotoxicity Evaluation

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Hydrofluoric acid (HF, 46% w/w aqueous solution), tetrahydrofuran (THF), and Eagle’s minimal essential medium (E-MEM) were purchased from Wako Pure Chemical Industries Ltd. (Osaka, Japan). Fetal bovine serum (FBS) was purchased from Cosmo Bio Co., LTD. (Tokyo, Japan). Poly(D,L-lactide) (PDLLA) and poly(ε-caprolactone) (PCL) were purchased from LACTEL Absorbable Polymers (Birmingham, AL, USA). Mg alloy ‘Original ZM10’ was developed and manufactured by Fuji Light Metal Co., Ltd. The component was analyzed with an inductively coupled plasma optical emission spectrometry (ICP-OES Agilent 720, Agilent Technologies, Santa Clara, CA, USA) as shown in Table S1.

Sasaki M., Xu W., Koga Y., Okazawa Y., Wada A., Shimizu I, & Niidome T. (2022). Effect of Parylene C on the Corrosion Resistance of Bioresorbable Cardiovascular Stents Made of Magnesium Alloy ‘Original ZM10’. Materials, 15(9), 3132.

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Synthesis of NHC-based Amphiphiles and Metal Complexes

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The NHC-based amphiphile (MS precursor), Pd-MS, and Au-MS were synthesized according to literature methods.^{5,6 (link)} Ag₂O was purchased from Tokyo Chemical Industry, Co., Ltd. Acetone (99.0%), dichloromethane (99.5%), methanol (99.5%), chloroform (99.0%) and tetrahydrofuran (THF) were purchased from Fujifilm Wako Pure Chemical Industries, Ltd. and were used as received.

Taira T., Yanagimoto T., Sakai K., Sakai H, & Imura T. (2021). Au(i)-, Ag(i)-, and Pd(ii)-coordination-driven diverse self-assembly of an N-heterocyclic carbene-based amphiphile. RSC Advances, 11(29), 17865-17870.

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Synthesis and Characterization of Magnesium Salt

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Example 16

(1) Synthesis of a Magnesium Salt

Under argon gas atmosphere, triphenylsilanol (5.53 g, 20 mmol) (Tokyo Chemical Industry Co., Ltd.) was dissolved in tetrahydrofuran (THF) (20 mL) (Wako Pure Chemical Industries, Ltd.), and then a THF solution of phenylmagnesium bromide (PhMgBr) (10 mL, 10 mmol) (Tokyo Chemical Industry Co., Ltd., 1 M) was added dropwise, and subjected to a reaction for 1 hour. After that, to an oil component generated by concentration and drying of the solution, diisopropyl ether (40 mL) (Wako Pure Chemical Industries, Ltd.) was added to generate powder. The powder was filtered off and dried to obtain magnesium bromide triphenylsiloxide (Ph₃SiOMgBr).

[Figure (not displayed)]

Measurement result of ¹H-NMR is shown below.

¹H-NMR (400 MHz, CDCl₃) δ (ppm): 6.95-7.90 (m, 15H)

(2) Preparation of the Electrolytic Solution

Under argon gas atmosphere, into magnesium bromide triphenylsiloxide (Ph₃SiOMgBr) (0.95 g), THF (10 mL) (Wako Pure Chemical Industries, Ltd.) was mixed. The mixture was heated to 50° C., and then aluminum chloride (AlCl₃) (0.33 g, 2.5 mmol) (Wako Pure Chemical Industries, Ltd.) was added to the mixture. After maintaining the resulting mixture at 50° C. for 10 minutes, it was cooled and filtrated to obtain the electrolytic solution 15, “a solution of magnesium bromide triphenylsiloxide-aluminum chloride/THF”.

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Synthesis and Characterization of Hollow Silica Particles

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Bis(triethoxysilyl)ethane was purchased from Oakwood Products, Inc. (Estill, SC, USA) and used as received. Triethoxymethylsilane was purchased from Tokyo Chemical Industry Co., Ltd (Tokyo, Japan) and used as received. Tetrahydrofuran (THF) and ethanol (super dehydrated) was purchased from FUJIFILM Wako Pure Chemical Co., Ltd (Osaka, Japan) and used as received. 6 mol L⁻¹ hydrochloric acid was purchased from FUJIFILM Wako Pure Chemical Co., Ltd (Osaka, Japan) and used as received without purification. Hollow silica particles with a median diameter of 18–65 μm (3M™ Glass Bubbles iM16K) were purchased from 3 M Japan Ltd (hereafter, hollow silica particles of iM16K were named as HSPs). The water was purified by a Millipore Mill-Q UV system and had a resistance of 18.2 MΩ cm and total organic carbon content of <10 ppb.

Tsukada S., Nakanishi Y., Hamada T., Okada K., Mineoi S, & Ohshita J. (2021). Ethylene-bridged polysilsesquioxane/hollow silica particle hybrid film for thermal insulation material. RSC Advances, 11(40), 24968-24975.

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