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Sumanirole maleate

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Sumanirole maleate is a selective dopamine D2 receptor agonist. It is used as a research tool to study the role of dopamine D2 receptors in biological systems.

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Lab products found in correlation

Pramipexole dihydrochloride, by Merck Group (1 mentions) Quinpirole hcl, by Merck Group (1 mentions) Apomorphine hcl, by Merck Group (1 mentions) Pd 128 907 hydrochloride, by Bio-Techne (1 mentions) R sch 23390 hydrochloride, by Merck Group (1 mentions) L 741 626, by Abcam (1 mentions) Nicotine, by Merck Group (1 mentions) Cl316 243 hydrate, by Merck Group (1 mentions) Arterenol, by Sanofi (1 mentions) Skf 38393 hydrochloride, by Merck Group (1 mentions) Aprepitant, by Selleck Chemicals (1 mentions) Sch 23390 hydrochloride, by Bio-Techne (1 mentions) Antalarmin hydrochloride, by Bio-Techne (1 mentions) 3 matida, by Bio-Techne (1 mentions) Ym202074, by Bio-Techne (1 mentions) Sc 19220, by Bio-Techne (1 mentions) Bay36 7620, by Bio-Techne (1 mentions) Nbi 35965 hydrochloride, by Bio-Techne (1 mentions) Mrs1754, by Bio-Techne (1 mentions) Ro 105824 dihydrochloride, by Bio-Techne (1 mentions)

4 protocols using sumanirole maleate

1

Pharmacological Evaluation of Dopamine Agonists

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Cocaine HCl and d-amphetamine sulfate were provided by the Research Technology Branch, National Institute of Drug Abuse (Rockville, MD, USA). (−)-quinpirole HCl, pramipexole dihydrochloride, and apomorphine HCl were purchased from Sigma-Aldrich (St. Louis, MO). Sumanirole maleate was purchased from Tocris Bioscience (Minneapolis, MN). All drugs were dissolved in physiologic saline, and administered IP in a volume of 10 ml/kg.
Collins G.T., Jackson J.A., Koek W, & France C.P. (2014). Effects of dopamine D2-like receptor agonists in mice trained to discriminate cocaine from saline: influence of feeding condition. European journal of pharmacology, 729, 123-131.
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2

Dopaminergic Receptor Agonist Protocols

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(–)-Nicotine and R(+)-SCH-23390 hydrochloride were purchased from Sigma-Aldrich (St. Louis, MO, United States). L-741,626, L-745,870 trihydrochloride, and (±)-SKF-38393 hydrochloride were purchased from Abcam (Cambridge, United Kingdom). U-99194 maleate, sumanirole maleate, and (+)-PD-128,907 hydrochloride were purchased from Tocris Bioscience (Bristol, United Kingdom). L-741,626 and L-745,870 were first dissolved in 1% lactate, and then they were diluted with distilled water. Other drugs were dissolved in saline.
Kato M., Kunisawa N., Shimizu S., Iha H.A, & Ohno Y. (2022). Mechanisms Underlying Dopaminergic Regulation of Nicotine-Induced Kinetic Tremor. Frontiers in Pharmacology, 13, 938175.
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3

Solubilized Dopaminergic and Adrenergic Agonists

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D1-agonist ( ±)-SKF-38393 hydrochloride (CAT# D047, Sigma), D2-agonist Sumanirole maleate (CAT# 2773, Tocris Bioscience), dopamine hydrochloride (CAT# ab120565, Abcam), ADRB3-agonist CL316,243 hydrate (CAT# C5976, Sigma), and NE compound “Arterenol” (CAT# 03870227, Sanofi) were solubilized to make identical stock concentrations in water or saline for ex vivo or in vivo studies, respectively. Final dilutions were freshly made in complete culture medium or saline for ex vivo or in vivo studies, respectively.
Raffaelli F.M., Resch J., Oelkrug R., Iwen K.A, & Mittag J. (2020). Dopamine receptor D1- and D2-agonists do not spark brown adipose tissue thermogenesis in mice. Scientific Reports, 10, 20203.
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4

Characterization of Pharmacological Compounds

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2-Bromo-α-ergocryptine methanesulfonate salt (BRM) was purchased from Sigma-Aldrich. Aprepitant was obtained from Selleck. All the other compounds tested were purchased from Tocris Biosciences, including SCH 23390 hydrochloride, rotigotine hydrochloride, sumanirole maleate, B-HT 920, Ro 10-5824 dihydrochloride, YM 202074, cinnabarinic acid, MTP, ICI 118,551 hydrochloride, GS 6201, PSB 1115, SC 19220, CP 154526, L-733060, CP 96345, TAM, DOX, A 412997 dihydrochloride, AMN 082 dihydrochloride, SKF 97541, Rac BHFF, SEW 2871, purmorphamine, (R)-(−)-α-methylhistamine dihydrobromide, methimepip dihydrobromide, VU 0155041 sodium salt, antalarmin hydrochloride, NBI 35965 hydrochloride, BQ 788 sodium salt, BAY36-7620, 3-MATIDA, MPEP hydrochloride, MRS 1754, SC 51322, SC 19220, and JTE 013.
Chen Y., Palczewska G., Masuho I., Gao S., Jin H., Dong Z., Gieser L., Brooks M.J., Kiser P.D., Kern T.S., Martemyanov K.A., Swaroop A, & Palczewski K. (2016). Synergistically acting agonists and antagonists of G protein–coupled receptors prevent photoreceptor cell degeneration. Science signaling, 9(438), ra74.
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