Liquid anti xa

Manufactured by Werfen

Sourced in France

Liquid Anti-Xa is a lab equipment product used to measure the anti-Xa activity of heparin in human plasma samples. It provides a quantitative assessment of the anticoagulant effect of heparin.

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Lab products found in correlation

Hemoclot thrombin inhibitors, by Hyphen Biomed (1 mentions) Hemosil, by Werfen (1 mentions) Readiplastin, by Werfen (1 mentions) Acl top 700 analyzer, by Werfen (1 mentions) Cobas 8000 modular, by Roche (1 mentions)

2 protocols using liquid anti xa

Anticoagulant Drug Monitoring Protocol

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In the first follow-up visit, pre- (trough) and post- (two hours after peak) drug intake anti-Xa activity (HemosIL, Liquid Anti-Xa, Werfen) was determined for patients on edoxaban, apixaban, and rivaroxaban; diluted thrombin time (dTT) was measured (HEMOCLOT Thrombin Inhibitors, Hyphen BioMed, Neuville-sur-Oise, France) for patients on dabigatran; and plasma concentrations (HemosIL, Liquid Anti-Xa suitably calibrated) were measured for patients on edoxaban.

Corrochano M., Acosta-Isaac R., Plaza M., Muñoz R., Mojal S., Moret C, & Souto J.C. (2022). Impact of increased kidney function on clinical and biological outcomes in real-world patients treated with Direct Oral Anticoagulants. PLOS ONE, 17(12), e0278693.

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Measurement of Direct Oral Anticoagulants

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The ACL‐TOP‐700 analyzer (Werfen) was used to measure the prothrombin time (PT, HemosIL ReadiPlasTin) and rivaroxaban or apixaban calibrated anti‐factor Xa assays (HemosIL, Liquid anti‐Xa).¹⁸, ¹⁹ The same analyzer was used to measure plasma drug concentrations for dabigatran using the diluted thrombin time (dTT, HemosIL Direct thrombin inhibitor) calibrated with a dabigatran calibrator²⁰ and the activated partial thromboplastin time (APTT, HemosIL Synthasil). The measurements were carried out following the manufacturer’s instructions. To minimize the risk of laboratory variation, all DOAC measurements were performed on the same day, using reagents from the same batch. Outlying results (i.e., values outside the two times standard deviation [SD] range, or peak values that were only slightly higher than the trough values) were remeasured in duplicate. In addition, creatinine levels were measured (Roche, COBAS 8000 modular) after which the creatinine clearance (CrCl) was estimated using the Cockcroft‐Gault formula.²¹

Toorop M.M., van Rein N., Nierman M.C., Vermaas H.W., Huisman M.V., van der Meer F.J., Cannegieter S.C, & Lijfering W.M. (2021). Inter‐ and intra‐individual concentrations of direct oral anticoagulants: The KIDOAC study. Journal of Thrombosis and Haemostasis, 20(1), 92-103.

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