Compritol 888 ato

Sesamol was obtained as a free gift from Jubilant Life Sciences (Noida, Uttar Pradesh, India); Compritol 888 ATO® was a gift sample from Gattefosse, USA. Soy Lecithin (Hi Media, India); Tween 80 (S.D. Fine Chemicals, India) and CCl₄ (Merck) were also used in the study. All other chemicals and reagents were of analytical grade.

Compritol^® 888 ATO (glyceryl behenate) and glyceryl monostearate (GMS) were purchased from Gattefossé (Paramus, NJ, USA). TA, Pluronic^® F-68 (Poloxamer 188), Tween^® 80, gellan gum, amicon ultra centrifugal filter devices, high-performance liquid chromatography (HPLC)-grade solvents, liquid chromatography mass spectroscopy (LCMS) optima-grade solvents, and other analytical-grade chemicals were purchased from Fisher Scientific (Hampton, NH, USA).

Atazanavir was obtained as a generous gift from Sun Pharmaceutical Industries Limited (Gurgaon, India). Labrafil^® M1944CS, Labrafil^® M2125CS, Labrafac^TM WL1349, Labrafac^TM PG, Lauroglycol^TM 90, Capryol^TM PGMC, Compritol^® 888ATO, Precirol^® ATO 5, Solutol HS15^®, Glyceryl monostearate, Gelucire^® 44/14, and Gelucire^® 43/10 were acquired by Gattefosse (Saint Priest, France). Capmul^® PG-12 EP/NF, Captex^® 100, and Captex^® 300 were obtained from Abitech Corporations (Cleveland, OH, USA). The surfactants like span 20, tween 80, and tween 20 were procured from Merck (Hohenbrunn, Germany). Poloxamer 188, Poloxamer 407, and Cremophor RH 40 were acquired from BASF (Mumbai, India). Sesame oil, canola oil, and castor oil were acquired from the central drug house (Mumbai, India). Water, methanol, and acetonitrile for HPLC were procured from Fischer Scientific Co. (Mumbai, India). Purified water used for all experiments was obtained from Milli Q Plus (Millipore, MA, USA). Rest of the chemicals and reagents were procured from S.D. Fine Chemicals Ltd. (Mumbai, India). Freshly prepared buffer solutions were used for all experiments.

Doxorubicin hydrochloride (DOX) was kindly provided by ACIC Chemicals (Ontario, Canada). Oleic acid was purchased from Sigma-Aldrich (St. Louis, MO, USA). Triethanolamine (TEA) was obtained from Merck (Darmstadt, Germany). Lipoid MCT was purchased from Lipoid GmbH (Ludiwigshafen, Germany). Monooleate of sorbitan (Span 80 ^®) and monooleate of sorbitan ethoxylated (Super Refined Polysorbate 80 ^®) was provided by Croda Inc. (Edison, NJ, USA). Glyceryl behenate (Compritol 888 ATO ^®) was provided by Gattefossé (Saint Priest, France). All other chemicals were of analytical grade.

Loratadine^® (LORA) was a gift from SEDICO Pharmaceutical Co., Egypt. Compritol 888 ATO^® (glyceryl behenate), Labrafil^® 2125 (linoleoyl polyoxyl-6 glycerides), and Labrasol^® (caprylocaproyl macrogol-8 glycerides) were purchased from Gattefosse (St-Priest, France). Sorbitan monostearate (Span^®60) was purchased from Oxford Laboratories Pvt. Ltd. Pharmaceutical Company, Mumbai, India. Brij^®35 (Polyoxyethylene lauryl ether) was supplied by Sigma-Aldrich (Spain) and Aladdin Chemistry Co., Ltd. (Shanghai, China), Hydroxypropyl methylcellulose HPMC k100 was purchased from Lobachemi, Pvt Ltd. Mumbai, India. All utilized analytical grade solvents, chemicals, and reagents were obtained from authorized sources.

The direct compression process of materials (dicalcium phosphate dihydrate, Di-Tab^®; Innophonos) and the drug ranitidine hydrochloride (˃99%) were donated by HELM Mexico. Glyceryl behenate (Compritol^® 888 ATO; Gattefossé) was purchased from Lyontec (Mexico City, Mexico). The stabilizing agent, Pluronic F-68^®, was obtained from Aldrich (Merck Chemicals GmbH, Germany). Distilled water was of Milli-Q quality (Millipore, Bedford, MD, USA). All other reagents were of at least analytical grade.