The clinically available [99mTc]Tc-DTPA or [99mTc]Tc-MAG3 renal scintigraphy that was acquired closest to the date of [68Ga]Ga-DOTA PET imaging was chosen. For 8/12 patients [99mTc]Tc-DTPA data and for 4/12 [99mTc]Tc-MAG3 data were available. Scintigraphy images were acquired in 36 frames of 10 s and 78 frames of 30 s on a Symbia S gamma camera (Siemens Healthineers, Erlangen, Germany) using a low energy high resolution collimator. Scans were started with DTPA/MAG3 injection (mean applied activity: 145 MBq of [99mTc]Tc-DTPA and 71 MBq of [99mTc]Tc-MAG3, respectively). To create renograms, C-shaped ROIs were drawn around each kidney [10 (link)]. Background correction was performed by subtraction of area-normalized background ROIs (C-shaped ROIs surrounding the lower, lateral, and upper part of the respective kidney). The renograms and PET-derived renal TACs were visually analysed in a consensus read by three nuclear medicine physicians (DK, MS, and CR).
Symbia s
Manufactured by Siemens
Sourced in United Kingdom, Germany
The Symbia S is a gamma camera system designed for nuclear medicine imaging. It captures images of the body's internal structures and functions by detecting gamma rays emitted by radioactive tracers injected into the patient. The Symbia S is a compact and versatile system that can be used for a variety of diagnostic procedures.
Automatically generated - may contain errors
Lab products found in correlation
Datscan, by GE Healthcare (4 mentions)
Hermes workstation, by Hermes Medical Solutions (3 mentions)
Symbia t6, by Siemens (1 mentions)
Intevo, by Siemens (1 mentions)
Acuson s2000 system, by Siemens (1 mentions)
Somatom as, by Siemens (1 mentions)
Flash 3d, by Siemens (1 mentions)
Symbia t2, by Siemens (1 mentions)
Lexiscan, by Astellas Pharma (1 mentions)
Somatom definition ct scanner, by Siemens (1 mentions)
Biograph mct pet ct system, by Siemens (1 mentions)
12 protocols using symbia s
1
Multimodal Renal Imaging: Tc-DTPA/MAG3 Scintigraphy and Ga-DOTA PET
2
Differential Renal Scintigraphy Protocol
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The DRS studies were performed using Symbia T6 and Symbia S scanners (Siemens, Erlangen, Germany). Prior to examination all patients were hydrated orally with 10 ml/kg of water. The image acquisition in posteroanterior view started simultaneously with intravenous injection of technetium-99 m-ethylenedicysteine (99mTc-EC) at a dose of 74–185 MBq depending on the body mass. Furosemide at a dose of 0.5-1 mg/kg (max. 20 mg) was administrated after 20 min of acquisition if the radionuclide continued to concentrate in the renal parenchyma. The images were analyzed by nuclear medicine specialists using dedicated software. Regions of interest were drawn manually on the heart, kidneys and perirenal background. Differential renal function was calculated using the Area Under the Curve method between 60 and 120 s after radionuclide administration. For the purpose of this study, the results of DRS were retrieved from patients’ medical history.
3
FP-CIT SPECT Imaging Protocol
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FP-CIT SPECT imaging was carried out at baseline. Three to six hours following a bolus intravenous injection of 185 MBq of 123 I-FP-CIT (DaTSCAN, GE Healthcare, UK) patients were scanned using a double headed gamma camera (Siemens Symbia S) fitted with a low energy high resolution (LEHR) parallel hole collimator. Images were classed as normal or abnormal based on consensus visual rating by a five-person panel, blind to any clinical data (Benamer et al., 2000) .
4
123I-FP-CIT Imaging Protocol for DaTSCAN
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Individuals were scanned three to six hours following a bolus intravenous injection of 185 MBq of 123I-FP-CIT (DaTSCAN, GE Healthcare, UK) using a dual headed gamma camera (Siemens Symbia S or Siemens Intevo) fitted with low energy high resolution (LEHR) parallel hole collimators. One hundred and twenty 25 second views over a 360° orbit (60 views per detector) were acquired on a 128×128 matrix with a zoom of 1.23x giving a pixel size 3.9mm × 3.9mm. Overall image acquisition time was 25 minutes.
5
DaTSCAN Imaging Protocol for Parkinson's
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Three to six hours following a bolus intravenous injection of 185 MBq of 123I-FP-CIT (DaTSCAN, GE Healthcare, UK), patients were scanned (25 min) using a double-headed γ camera (Siemens Symbia S) fitted with a low-energy high-resolution parallel hole collimator. One hundred and twenty (60 per detector) 25 s views over a 360° orbit were acquired on a 128 × 128 matrix with a zoom of 1.23× giving a pixel size of 3.9 mm × 3.9 mm. Image processing and display were then performed on a Hermes workstation (Hermes Medical Solutions, Stockholm, Sweden). Images were reconstructed without attenuation correction using filtered back projection and a Butterworth filter (order 10, cut-off 1.3 cycles/cm). Transverse sections were then manually reoriented to correct for any head tilt and to provide a consistent display.
6
Assessing Cardiac Function with Tc-tetrofosmin SPECT
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7
Multimodal Imaging Evaluation of Cancer
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CT examinations were performed on dedicated CT scanners (Siemens Flash, Siemens Somatom AS, Siemens Healthineers, Erlangen, Germany). Iodinated contrast medium was administered intravenously 70 s before the scan. CT was acquired using the manufacturer-supplied dose reduction CareKV and CareDose 4D.
Axillary sonography was conducted by experienced gynecologists (A.K.B. and S.M.) with over 10 years of expertise in breast and axillary ultrasound. The following systems and transducers were utilized: an Acuson S2000 system (Siemens Healthcare GmbH, Erlangen, Germany), a SuperSonic Imagine Aixplorer (Toshiba Medical Systems GmbH, Neuss, Germany) and an Aplio MX SSA-780A System (Toshiba Medical Systems GmbH, Neuss, Germany), all equipped with 5 to 12 MHz linear array transducers.
Bone scintigraphy was performed with planar whole-body scans using a dual-headed gamma camera equipped with low-energy high-resolution collimator (Symbia S, Siemens Healthineers). Three hours after intravenous injection of a body-weight-adapted amount of [99mTc]-labeled polyphosphonate (PDP), anterior and posterior view scans were acquired with an acquisition time of 20 to 35 min. In all cases of uncertain radionuclide accumulations in the bone scan, additional target images or SPECT/CT images were acquired.
Axillary sonography was conducted by experienced gynecologists (A.K.B. and S.M.) with over 10 years of expertise in breast and axillary ultrasound. The following systems and transducers were utilized: an Acuson S2000 system (Siemens Healthcare GmbH, Erlangen, Germany), a SuperSonic Imagine Aixplorer (Toshiba Medical Systems GmbH, Neuss, Germany) and an Aplio MX SSA-780A System (Toshiba Medical Systems GmbH, Neuss, Germany), all equipped with 5 to 12 MHz linear array transducers.
Bone scintigraphy was performed with planar whole-body scans using a dual-headed gamma camera equipped with low-energy high-resolution collimator (Symbia S, Siemens Healthineers). Three hours after intravenous injection of a body-weight-adapted amount of [99mTc]-labeled polyphosphonate (PDP), anterior and posterior view scans were acquired with an acquisition time of 20 to 35 min. In all cases of uncertain radionuclide accumulations in the bone scan, additional target images or SPECT/CT images were acquired.
8
Intratherapeutic Radioiodine Imaging Protocol
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We prefer using the term intratherapeutic imaging instead of posttherapeutic imaging to avoid confusion with follow-up imaging. The intratherapeutic WBS was performed 5-10 d after radioiodine therapy (mean 131 I activity, 4.4 GBq; median, 3.0 GBq; range, 1.0-10.0 GBq) using a doublehead g-camera (Symbia S; Siemens) equipped with a high-energy, parallelhole collimator. The table speed was 15 cm/min. The matrix was 256 • 1,024, resulting in 2.4 • 2.4 mm pixels.
All patients underwent SPECT/CT of the neck on a scanner (Symbia T2; Siemens) equipped with a high-energy, parallel-hole collimator. Low-dose CT for attenuation correction was performed without a contrast agent (tube voltage, 130 kVp; tube current-time product, 17 mAs; beam pitch, 1.5; slice width, 5 mm). The SPECT scan was acquired using 128 angles over 360°a nd 25 s per stop. Images were iteratively reconstructed and corrected for attenuation and scatter (Flash 3D [Siemens], 4 subsets and 8 iterations; gaussian intersliced smoothing filter; attenuation coefficient, 0.15 cm 21 ). The image matrix was 128 • 128, resulting in a cuboid voxel length of 4.8 mm.
All patients underwent SPECT/CT of the neck on a scanner (Symbia T2; Siemens) equipped with a high-energy, parallel-hole collimator. Low-dose CT for attenuation correction was performed without a contrast agent (tube voltage, 130 kVp; tube current-time product, 17 mAs; beam pitch, 1.5; slice width, 5 mm). The SPECT scan was acquired using 128 angles over 360°a nd 25 s per stop. Images were iteratively reconstructed and corrected for attenuation and scatter (Flash 3D [Siemens], 4 subsets and 8 iterations; gaussian intersliced smoothing filter; attenuation coefficient, 0.15 cm 21 ). The image matrix was 128 • 128, resulting in a cuboid voxel length of 4.8 mm.
9
FP-CIT SPECT Imaging Protocol
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FP-CIT SPECT imaging was carried out at baseline. Three to six hours following a bolus intravenous injection of 185 MBq of 123 I-FP-CIT (DaTSCAN, GE Healthcare, UK) patients were scanned using a double headed gamma camera (Siemens Symbia S) fitted with a low energy high resolution (LEHR) parallel hole collimator. Images were reconstructed in transverse sections and classed as normal or abnormal based on visual rating (Benamer et al., 2000) .
10
SPECT Imaging for Cardiac Ischemia Assessment
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All patients underwent clinically indicated SPECT imaging for symptoms suspicious of cardiac ischemia as determined by their treating physician. All SPECT imaging studies were completed using standard stress/rest protocols. Technetium tetrafosmin (GE Healthcare, Chicago, IL) was used as a radiotracer and dosing was weight based. Patients underwent standard Bruce or modified Bruce treadmill exercise protocols unless they were unable to safely exercise or did not achieve 85% of their predicted maximum heart rate with exercise. In such cases, patients underwent a pharmacological stress protocol using 0.4 mg/5 mL intravenous regadenoson (Lexiscan, Astellas Pharma US Inc.) injection. SPECT images were acquired using a Symbia S (Siemens Healthcare, Hoffman-Estates, IL) dual-head gamma camera.
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