Women with CPP in NHS Lothian (UK), already recruited as part of a pilot randomised controlled trial (RCT) conducted in NHS Lothian and NHS Grampian (UK) to investigate the efficacy of gabapentin versus placebo in CPP management,10 11 (link) were approached and invited to participate in this embedded fMRI substudy. The pilot RCT aimed to enrol 60 participants over a 9-month period. The brain fMRI scans were carried out on a Siemens Verio 3T MRI Scanner located at the Edinburgh Imaging Facility, Queens Medical Research Institute (previously known as the Edinburgh Clinical Research Imaging Centre), at the University of Edinburgh (UK). A 12 channel receiver head coil was used. Other study measures were tested in NHS Lothian clinical research facilities or, where appropriate, via the telephone.
Verio 3t mri scanner
Manufactured by Siemens
Sourced in Germany
The Verio 3T MRI scanner is a magnetic resonance imaging system produced by Siemens. It operates at a field strength of 3 Tesla and is designed for clinical use in medical imaging applications.
Automatically generated - may contain errors
18 protocols using verio 3t mri scanner
1
Gabapentin for Chronic Pelvic Pain
2
Facial Emotion Recognition via MEG & MRI
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A facial expression paradigm was undertaken in this study. A series pictures were utilized to evoke stronger activity contrast. The emotional pictures included three conditions, neutral, sad and rest, where a fixation cross was displayed. Each condition had 40 trials and each lasted for 3 s, followed by a blank screen during the variable stimulus interval of 0.5 s, 1 s or 1.5 s. When scanned, the subjects were asked to identify whether the stimuli was sad or not by right hand click.
MEG data was recorded at a sampling rate of 1200 Hz using an Omega 2000 device of 275 channels placed in a magnetically shielded room (MSR), which provided a considerable amount of shielding from noise and interference.
DTI data and T1-weighted axial images were acquired using a Siemens Verio 3 T MRI scanner. The parameters for T1-weighted axial images were repetition time/echo time (TR/TE) =1900/2.48 ms, thickness/gap = 1.0/0 mm, matrix = 256 × 256 × 192, field of view (FOV) = 240 × 240 mm2, voxel size = 1 × 1 × 1 mm3. The following parameters were used for DTI scans, diffusion was measured along 30 non-collinear directions (b value = 1000s/mm2), TR/TE = 6600 ms/93 ms, FOV = 240 mm × 240 mm, Matrix = 128 × 128 × 45, voxel size = 1.875 × 1.875 × 3 mm3.
MEG data was recorded at a sampling rate of 1200 Hz using an Omega 2000 device of 275 channels placed in a magnetically shielded room (MSR), which provided a considerable amount of shielding from noise and interference.
DTI data and T1-weighted axial images were acquired using a Siemens Verio 3 T MRI scanner. The parameters for T1-weighted axial images were repetition time/echo time (TR/TE) =1900/2.48 ms, thickness/gap = 1.0/0 mm, matrix = 256 × 256 × 192, field of view (FOV) = 240 × 240 mm2, voxel size = 1 × 1 × 1 mm3. The following parameters were used for DTI scans, diffusion was measured along 30 non-collinear directions (b value = 1000s/mm2), TR/TE = 6600 ms/93 ms, FOV = 240 mm × 240 mm, Matrix = 128 × 128 × 45, voxel size = 1.875 × 1.875 × 3 mm3.
3
Resting-State fMRI Acquisition Protocol
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All scans were acquired on a Siemens Verio 3T MRI scanner using a 32-channel head coil. Initially, a structural image was obtained using a high-resolution T1-weighted MPRAGE sequence with 1mm isotropic voxels. Resting-state fMRI data were recorded using a EPI pulse sequence with a TR/TE = 2580/30 ms, a flip angle of 80° and 3.5 mm isotropic voxel resolution without an interslice gap. The overall scan comprised 180 volumes prior to which subjects were instructed to keep their eyes closed.
4
MRI Acquisition Protocol for Brain Imaging
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All MRI data were acquired using a Siemens Verio 3 T MRI scanner with a 32‐channel head coil at the Functional Magnetic Resonance Imaging of the Brain Centre (FMRIB), University of Oxford. T1‐weighted structural brain images were acquired for each participant at 1mm isotropic resolution (MPRAGE; 192 transverse slices, TR = 2,040 ms, TE = 4.7 ms, flip angle = 8°). A gradient‐echo echo‐planar imaging (GRE‐EPI) sequence was used to acquire 312 volumes per scan run (36 transverse slices, 3 mm isotropic voxels, TR = 2,000 ms, TE = 30 ms, flip angle = 90°). Three runs of this sequence were acquired per scanner visit.
5
Multimodal Neuroimaging Protocol for Food Perception
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Scanning was performed on a Siemens Verio 3T MRI scanner with a 32-channel phased array head coil. Anatomical images were acquired at the beginning of each scan using a T1-weighted magnetization-prepared rapid acquisition with gradient echo pulse sequence (1-mm isotropic voxels, repetition time = 2,300 ms, echo time = 2.98 ms, flip angle = 9°, 160 axial slices). Functional images were acquired using a 3D echo planar imaging sequence (3-mm isotropic voxels, repetition time = 2,000 ms, echo time = 30 ms, flip angle = 80°, 35 axial slices). A different number of volumes was acquired for each task depending on the task duration: Each food image task was ∼10 min and 305 volumes, and the resting state was ∼8 min and 240 volumes.
6
Resting-State fMRI in 3T MRI Scanner
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All MRI scans were performed on a Siemens Verio 3T MRI scanner using a 32-channel head coil. For each subject a structural image was obtained using a high-resolution 3D MPRAGE T1-weighted sequence with 1 mm isotropic voxel resolution. Functional resting-state images were acquired using a T2*-weighted echo-planar imaging (EPI) pulse sequence collecting 180 volumes with a TR = 2580 ms, flip angle = 80° and 3.5 mm isotropic voxel resolution. Prior to the resting-state scan the subjects were instructed to keep their eyes closed and not to fall asleep during the scanning procedure. Using the same field of view as the functional restingstate images, field maps were acquired (TE = 7.38/4.92 ms, TR = 675 ms) to correct for susceptibility artifacts and inhomogeneity of the magnetic field during preprocessing of the resting-state data.
7
Multimodal MRI Acquisition Protocol
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Data were acquired on a Siemens Verio 3-T MRI scanner with foam padding surrounding each participant’s head to reduce head movement. For each participant, we acquired a structural T2-weighted echo-planar imaging volume (MPRAGE)—spin-echo, repetition time (TR) = 2300 ms, echo time (TE) 1.97 ms, matrix size = 256 × 256, 1.0-mm isovoxel, field of view (FOV) = 256 mm, 176 slices, 1-mm thick, flip angle 9°, bandwidth = 240 Hz/Px (coplanar with the functional scans). Both runs of the values and math stress task lasted 706 s (11 min, 46 s)—gradient-echo, TR = 2000 ms, TE = 25 ms, multiband factor 3, matrix size 70 × 70, 3.0-mm isovoxel, FOV = 210 mm, 51 axial slices, 3-mm thick, flip angle 79°, bandwidth = 1930 Hz/Px, collected at a 38° slice angle.
8
Quality-Controlled Multimodal MRI Acquisition
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Images were acquired using a Siemens Verio 3T MRI scanner. The following acquisitions were performed as part of a multi-modal MR examination: whole brain T1-weighted scan (MPRAGE, 160 slices, voxel size 1.0mm 3 , TR=2300ms, TE=2.98ms, FA=9 o ); ASL (PICORE Q2T, 50 pairs of control/ tag images, TR=2500ms, TE=11ms, inversion time=1800ms, bolus duration=700ms, voxel size 3.0x3.0x6.0mm, axial slices=14, slice gap=1.5mm, FA=90 o ).
ASL scans were quality controlled by visual inspection, scans were excluded due to ASLrelated artefacts (e.g. fat saturation artefact and labelling asymmetry), brain abnormalities such as tumour, or if field of view (FOV) was inadequate. FOV was judged to be inadequate if any of the superior or posterior aspect was cropped or if cropping of the inferior aspect impinged on the hippocampus which was defined according to the Desikan-Killiany atlas.
See figure 1 for scan inclusion/ exclusion pathway. ASL data from 162/193 (83.9%) individuals were available for analysis.
ASL scans were quality controlled by visual inspection, scans were excluded due to ASLrelated artefacts (e.g. fat saturation artefact and labelling asymmetry), brain abnormalities such as tumour, or if field of view (FOV) was inadequate. FOV was judged to be inadequate if any of the superior or posterior aspect was cropped or if cropping of the inferior aspect impinged on the hippocampus which was defined according to the Desikan-Killiany atlas.
See figure 1 for scan inclusion/ exclusion pathway. ASL data from 162/193 (83.9%) individuals were available for analysis.
9
Functional Neuroimaging with MRI
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MRI data were obtained on a Siemens Verio3T MRI scanner using a standard 6-channel head coil (Erlangen, Germany) in the Department of Radiology, People’s hospital of Hainan Province. During the scanning, subjects were required to remain their eyes closed and at the same time stay awake, to insure thinking of nothing particularly, and to maintain their heads still. In order to rule out gross cerebral pathology, a routine structure MR scan was conducted. Then spin-echo imaging was used to collect anatomical images of the functional slice locations in the axial plan parallel to the Anterior Commissure-Posterior Commissure (AC-PC) line. Whole-brain functional images were acquired with a T2*-weighted EPI sequence sensitive to BOLD contrast (repetition time = 2000 ms, echo time = 30 ms, field of view = 240 × 240 mm, flip angle = 80°, image matrix = 64 × 64, voxel size = 3.75 × 3.75 × 5 mm. Each brain volume included 31 axial slices and each functional run comprised 240 volumes). A high-resolution T1-weighted structural image was acquired using a MPRAGE sequence (repetition time = 2300 ms, echo time = 2.9 ms, TI = 900 ms, field of view = 256 × 256 mm, flip angle = 9°, in-plane matrix = 256 × 256, slice thickness = 1 mm, no gap, and voxel dimension = 1 × 1 × 1.33 mm).
10
High-Resolution Structural Imaging with 3T MRI
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T1‐weighted magnetization‐prepared rapid gradient echo (T1‐MPRAGE) images were obtained with a Siemens Verio 3T MRI scanner (Siemens AG, Erlangen, Germany) scan using the following parameters: repetition time (TR) = 2300 milliseconds, echo time (TE) = 2.98 milliseconds, inversion time = 900 milliseconds, flip angle = 9°, 176 slices, and 1.0 × 1.0 × 1.0 mm3 voxel size. Receiver bandwidth and echo spacing were 240 Hz/pixel and 7.1 milliseconds, respectively. Total scan acquisition time was 9 minutes 14 seconds.
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