Ketamine

Manufactured by Cerilliant

Sourced in United States

Ketamine is a laboratory equipment product that is used as an anesthetic. It is a dissociative anesthetic agent that works by interrupting the flow of sensory information to the brain. Ketamine is utilized in medical and research settings for its ability to induce a trance-like state, provide pain relief, and produce sedation.

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Lab products found in correlation

Mephedrone, by Cerilliant (3 mentions) Norketamine, by Cerilliant (3 mentions) 3 4 methylenedioxymethamphetamine, by Cerilliant (2 mentions) Amphetamine, by Cerilliant (2 mentions) Benzoylecgonine, by Cerilliant (2 mentions) Methamphetamine, by Cerilliant (2 mentions) 7 aminonimetazepam, by Cerilliant (2 mentions) Codeine, by Cerilliant (2 mentions) Morphine, by Cerilliant (2 mentions) Methanol, by Merck Group (1 mentions) Methylone, by Cerilliant (1 mentions) Nitrazepam, by Cerilliant (1 mentions) Formic acid, by Merck Group (1 mentions) Para methoxymethamphetamine, by Cerilliant (1 mentions) Milli q ultrapure water system, by Merck Group (1 mentions) Codeine d6, by Cerilliant (1 mentions) Morphine d6, by Cerilliant (1 mentions) Hplc grade acetonitrile, by Avantor (1 mentions) Sodium azide, by Merck Group (1 mentions) Flunitrazepam, by Cerilliant (1 mentions)

Close spelling variants of this product

Ketamine-D4 (3 citations)

5 protocols using ketamine

Detection and Quantification of Illicit Drugs

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Chloroform (CHCl₃) and ethyl acetate (EA) were purchased from Macron Fine Chemicals (Center Valley, PA, U.S.A.). Formic acid and methanol were obtained from Sigma–Aldrich(St. Louis, MO, U.S.A.) and Merck (Darmstadt, Germany), respectively. Ethanol and acetic acid were purchased from J.T. Baker (Phillipsburg, NJ, U.S.A.). Distilled deionized water was produced by a PURELAB purifier (ELGA, Marlow, U.K.). Standards for illegal drugs including 5-MeO-AMT, amphetamine (AM), methamphetamine (MA), mephedrone, para-methoxymethamphetamine (PMMA), 3,4-methylenedioxymethamphetamine (MDMA), methylone, 2-(4-chloro-2,5-dimethoxyphenyl)ethan-1-amine (2C-C), ketamine, nitrazepam, flunitrazepam (FM2), and lysergic acid diethylamide (LSD) were purchased from Cerilliant Corporation (Round Rock, TX, U.S.A.). Stock solutions of illicit drugs were prepared in MeOH. Drinks and powders for whole fat milk (Uni-President Enterprises Corporation), grape juice (Uni-President Enterprises Corporation), fruit and vegetable juice (Chou-Chin Industrial Co.), sugar-free green tea bags (Vitalon Foods Company), 3-in-1 instant coffee packs (Nestlé Company), matcha tea packs (Starbucks), and gelatin powder (Tehmag Foods Corporation) were obtained from local supermarkets. Postage stamps were purchased from Chunghwa Post Co., Taiwan.

Cheng S.C., Tsai Y.D., Lee C.W., Chen B.H, & Shiea J. (2019). Direct and rapid characterization of illicit drugs in adulterated samples using thermal desorption electrospray ionization mass spectrometry. Journal of Food and Drug Analysis, 27(2), 451-459.

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Quantification of Illicit Drugs in Cough Syrups

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Carbinoxamine, chlorpheniramine, and chlorpheniramine-d₆ were purchased from TRC (North York, Canada). Individual solutions of 6-AM, 7-aminonitrazepam, 7-aminonimetazepam, amphetamine, benzoylecgonine, C6G, codeine, codeine-d₆, ketamine, methamphetamine, mephedrone, 4-methylephedrine, 3,4-methylenedioxymethamphetamine hydrochloride, M3G, M6G, morphine, morphine-d₆, and norketamine (each with a concentration of 1 mg mL⁻¹) were purchased from Cerilliant (Round Rock, TX, USA). Three brands of cold syrups (Consrine, ssBuron, and Pabron) manufactured in Taiwan were purchased from local pharmacies. Consrine contains codeine phosphate (0.48 mg mL⁻¹), chlorpheniramine (0.25 mg mL⁻¹), dl-methyl ephedrine HCl (1.6 mg mL⁻¹), and glycyrrhizic acid (0.25 mg mL⁻¹), ssBuron contains codeine phosphate (0.5 mg mL⁻¹), guaifenesin (3.33 mg mL⁻¹), chlorpheniramine maleate (0.14 mg mL⁻¹), and caffeine (1.33 mg mL⁻¹), Pabron contains codeine phosphate (0.48 mg mL⁻¹), dl-methyl ephedrine HCl (2.5 mg mL⁻¹), and carbinoxamine maleate (0.4 mg mL⁻¹). Formic acid and methanol (high-performance LC grade) (≥ 98%) were purchased from J.T. Baker (Pittsburgh, PA, USA). Ultrapure water (18.2 mΩ·cm) obtained from a Milli-Q ultrapure water system (Millipore, Billerica, MA, USA) was used in this study.

Yen Y.T., Chang Y.J., Lai P.J., Chang C.L., Chen T.Y, & Chyueh S.C. (2020). A Study of Opiate, Opiate Metabolites and Antihistamines in Urine after Consumption of Cold Syrups by LC-MS/MS. Molecules, 25(4), 972.

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Quantitative Analysis of Illicit Drugs and Novel Psychoactive Substances

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LC–MS-grade methanol (purity, ≥99.9%) was purchased from Merk (Darmstadt, Germany). HPLC-grade acetonitrile (purity, ≥99.9%) was purchased from J.T. Baker (Phillipsburg, NJ, USA). Ten standards of illicit drugs, meth amphetamine (1 mg/mL), amphetamine (1 mg/mL), ketamine (1 mg/mL), norketamine (1 mg/mL), morphine (0.1 mg/mL), codeine (1 mg/mL), Tetrahydrocannabinol (THC, 1 mg/mL), 11-nor-9-carboxy-THC (THC-COOH, 0.1 mg/mL), 3,4-methylenedioxymeth amphetamine (MDMA, 1 mg/mL), mephedrone (1 mg/mL), flunitrazepam (1 mg/mL), 7-aminoflunitrazepam (1 mg/mL), nimetazepam (1 mg/mL), 7-aminonimetazepam (1 mg/mL), and zopiclone (1 mg/mL) were purchased from Cerilliant (Round Rock, TX, USA). Three standards of NPSs, 4′-chloro-alpha-pyrrolidinopropiophenone (4-Cl-α-PPP, 1 mg, purity, ≥98%), 4′-Fluoro-α-pyrrolidinopentiophenone (4-F-α-PVP, 1 mg, purity, ≥98%), and 1-pentyl-3-(2-bromophenylacetyl)indole (JWH-249, 1 mg, purity, ≥98%) were purchased from Cayman Chemicals (Ann Arbor, MI, USA). Sodium azide (500 mg, purity, ≥99%) was purchased from Sigma-Aldrich (St. Louis, MO, USA).

Chen Y.C., Hsu J.Y., Chang C.W., Chen P.Y., Lin Y.C., Hsu I.L., Chu C.J., Lin Y.P, & Liao P.C. (2023). Investigation of New Psychoactive Substances (NPS), Other Illicit Drugs, and Drug-Related Compounds in a Taiwanese Wastewater Sample Using High-Resolution Mass-Spectrometry-Based Targeted and Suspect Screening. Molecules, 28(13), 5040.

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Quantitative Analysis of Ketamine and Metabolites

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ketamine dosing solution was purchased from Putney, Inc. (Portland, MA) and either used as directed or aseptically diluted using sterile saline to a final concentration of 25 mg/mL. The concentration of the ketamine dosing formulations was verified using LC-MS as described below. Atropine was purchased from Sigma Aldrich (St. Louis, MO) and prepared at a concentration of 15 mg/mL in sterile saline. The pH of the vehicle was acidified with dilute hydrochloric acid to increase solubility before being neutralized to pH 7.2 with dilute sodium hydroxide. The 2-PAM used was purchased from Sigma Aldrich (St. Louis, MO) and prepared at 50 mg/mL in sterile saline and sterile filtered. Midazolam (5 mg/mL) was purchased from Hospira (Lake Forest, IL) and used without modification.
The analytical reference standards for ketamine, norketamine, ketamine-d4, and norketamine-d4 in methanol were obtained from Cerilliant (Round Rock, TX). Multiple lots of K₃EDTA rat plasma and brains were obtained from Bioreclamation (Westbury, NY). Purified water was collected from an in-house Labconco (Kansas City, MO) Water Pro Plus system. Glacial acetic acid was obtained from JT Baker (Center Valley, PA). Ammonium hydroxide was obtained from Sigma Aldrich (St. Louis, MO). LC-MS-grade water and acetonitrile were obtained from EMD (Billerica, MA). Formic acid was obtained from Thermo Scientific (Waltham, MA).

Moeller B., Espelien B., Weber W., Kuehl P., Doyle-Eisele M., Garner C.E., McDonald J.D., Garcia E., Raulli R, & Laney J. (2018). The Pharmacokinetics of Ketamine Following Intramuscular Injection to F344 Rats. Drug testing and analysis, 11(1), 68-76.

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Quantification of Pharmaceutical Markers

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All chemicals and their corresponding isotopically-labeled analogs were obtained from various vendors. Acetaminophen, Acetaminophen-d4, amitriptyline, amitriptyline-d3, aripiprazole, aripiprazole-d8, benzoylecgonine, benzoylecgonine-d3, buprenorphine, buprenorphine-d4, caffeine, carbamazepine, carbamazepine-d10, diltiazem, diphenhydramine, diphenhydramine-d3, duloxetine, duloxetine-d3, fluoxetine, fluoxetine-d6, ketamine, ketamine-d3, methylphenidate, methylphenidate-d9, norfluoxetine, norfluoxetine-d6, promethazine, promethazine-d3, and sertraline were purchased as certified analytical standards from Cerilliant (Round Rock, TX, USA). Diamond UV water purification system was used throughout sample analysis to provide 18 MΩ water.

Ondarza P.M., Haddad S.P., Avigliano E., Miglioranza K.S.B, & Brooks B.W. (2019). Pharmaceuticals, illicit drugs and their metabolites in fish from Argentina: Implications for protected areas influenced by urbanization. The Science of the total environment, 649.

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