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Api 5500q system

Manufactured by Thermo Fisher Scientific
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The API 5500Q system is a triple quadrupole mass spectrometer designed for high-performance quantitative and qualitative analysis. It provides accurate and sensitive detection of a wide range of analytes. The system's core function is to perform mass spectrometry analysis, enabling researchers and analysts to identify and quantify compounds of interest in various sample types.

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Lab products found in correlation

Analyst version 1, by Thermo Fisher Scientific (2 mentions)

2 protocols using api 5500q system

1

Tandem Mass Spectrometry for Derivatized Amino Acids

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Tandem mass spectrometry (MS/MS) analysis was performed using a triple quadrupole mass spectrometer model API 5500Q system from Applied Biosystems/MDS Sciex equipped with Turbo V electrospray ionization source (TIS)® (Applied Biosystems, Foster City, CA, USA). The data was acquired and analyzed using Analyst version 1.5.1 (Applied Biosystems). Positive electrospray ionization data were acquired using multiple reaction monitoring (MRM). The TIS instrumental source settings for temperature, curtain gas, ion source gas 1 (nebulizer), ion source gas 2 (turbo ion spray), collision energy, and ion spray voltage were 550 °C, 20 psi, 45 psi, 80 psi, 15 V, and 4,500 V, respectively. The TIS compound parameter settings for declustering potential, entrance potential, and collision cell exit potential were 80, 10, and 10 V, respectively. The standards were characterized using the following MRM ion transitions: D-Ser and L-Ser derivatization products (m/z 231.5 to 106.1) and D-Arg derivatization product (m/z 300.4 to 175.0).
Moaddel R., Luckenbaugh D.A., Xie Y., Villaseñor A., Brutsche N.E., Machado-Vieira R., Ramamoorthy A., Lorenzo M.P., Garcia A., Bernier M., Torjman M.C., Barbas C., Zarate CA J.r, & Wainer I.W. (2014). D-serine plasma concentration is a potential biomarker of (R,S)-ketamine antidepressant response in subjects with treatment-resistant depression. Psychopharmacology, 232(2), 399-409.
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2

Mass Spectrometry Analysis of Amino Acid Derivatives

Check if the same lab product or an alternative is used in the 5 most similar protocols
MS/MS analysis was performed using a triple quadrupole mass spectrometer model API 5500Q system from Applied
Biosystems/MDS Sciex equipped with Turbo V electrospray ionization source (TIS)® (Applied Biosystems,
Foster City, CA, USA). The data was acquired and analyzed using Analyst version 1.5.1 (Applied Biosystems). Positive
electrospray ionization data were acquired using multiple reaction monitoring (MRM). The TIS instrumental source settings for
temperature, curtain gas, ion source gas 1 (nebulizer), ion source gas 2 (turbo ion spray), collision energy and ion spray
voltage were 550 °C, 20 psi, 45 psi, 80 psi, 15 V and 4500 V, respectively. The TIS compound parameter settings for
declustering potential, entrance potential, and collision cell exit potential were 80 V, 10 V, and 10 V, respectively. The
standards were characterized using the following MRM ion transitions: DSR derivatization product
(m/z 231.5 to 106.1) and D-Arg derivatization product
(m/z 300.4 to 175.0).
Pradhan B., Mitrev L., Moaddel R, & Wainer I.W. (2018). D-Serine is a potential biomarker for clinical response in treatment of post-traumatic stress disorder using (R,S)-ketamine infusion and TIMBER psychotherapy: A pilot study. Biochimica et biophysica acta. Proteins and proteomics, 1866(7), 831-839.
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