All PET images were acquired using combined PET/computed tomography (CT) in-line systems (Biograph TruePoint; Siemens Medical Solutions, Erlangen, Germany or Discovery 710D; GE Healthcare, Chicago, IL, USA). An average of 296 MBq 18F-florbetaben was injected intravenously, and the scan was initiated 90 minutes later. A low-dose CT scan was performed for attenuation correction and was immediately followed by PET in three-dimensional mode for 20 minutes. The subject's head was fixed using a head holder in order to minimize motion artifacts. The standard ordered subset expectation maximization algorithm (21 subsets with 3 iterations or 16 subsets with 4 iterations) was utilized for the reconstruction of PET images. All PET images were reviewed by nuclear medicine physicians who were blinded to the results of neuropsychological testing and successfully completed the electronic training program provided by the manufacturer. The result was dichotomized into amyloid positivity or negativity using visual assessments. The participants also underwent scanning on a 3.0-Tesla MRI device (Signa Excite 11.0, GE Medical Systems, Milwaukee, WI, USA) consisting of SWI and/or GRE T2-weighted imaging, as well as conventional T1-weighted, T2-weighted, and fluid-attenuated inversion recovery (FLAIR) sequences.
Discovery 710d
Manufactured by GE Healthcare
Sourced in Germany
The Discovery 710D is a medical imaging system designed for use in healthcare facilities. It is capable of performing various diagnostic imaging procedures. The core function of the Discovery 710D is to capture and generate high-quality images for medical professionals to aid in patient diagnosis and treatment.
Automatically generated - may contain errors
2 protocols using discovery 710d
1
Multimodal Amyloid Imaging in Dementia
2
FDG PET/CT Imaging Protocol
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All patients fasted for at least 6 h before the FDG PET/CT scan. An amount of 3.7~5.5 MBq/kg FDG was injected intravenously, and scanning began 60 min later. No intravenous contrast agent was administered. Images were acquired using a combined PET/CT in-line system (Biograph Duo, Biograph Truepoint, Biograph mCT, Siemens Medical Solutions; Discovery 710D, GE Healthcare). The acquisition time was 2~3 min per bed position. All patients were in the supine position during PET/CT scanning. Non-contrast-enhanced low-dose CT began at the orbitomeatal line and progressed to the proximal thigh using a standard protocol: 130 kVp, 80 mAs, 5-mm slice thickness (Biograph Duo); 120 kVp, 50 mAs, 5-mm slice thickness (Biograph Truepoint); 100~120 kVp, variable mAs adjusted by topographic image, 3-mm slice thickness (Biograph mCT); and 120 kVp, variable mAs adjusted by topographic image, 2.5-mm slice thickness (Discovery 710D). PET scans of the same body region followed immediately. The CT data were used for attenuation correction, and images were reconstructed using a standard ordered-subset expectation maximization algorithm.
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